姓名：高瑜
性别：女
职称：副教授
学历：博士
职务：
电话：
专业：药剂学
电子邮件：hellogaoyu@126.com
研究方向：抗肿瘤转移纳米药物输送系统
教育工作经历
☆2005.09–2010.07中国科学院上海药物研究所博士
专业：药剂学
☆2001.09–2005.07福州大学学士
专业：制药工程
工作经历
☆2010.07–2011.10中国科学院上海药物研究所助理研究员
☆2013.03–至今福州大学副教授
教学简介
本科生课程：《综合化学实验》、《仪器分析实验》
助教课程：《无机和分析化学》、《仪器分析》
科研简介
社会兼职
科研项目
代表性论文
2)YuGao,JingweiShao,ZhouJiang,SongenGu,SuhongYu,KeZheng,LeeJia*.Drugenterohepaticcirculationanddisposition:constituentsofsystemspharmacokinetics.DrugDiscoveryToday19(2014)326-340.(IF=6.551)
3)JianzhongChen,JichuangWang,JingweiShao,YuGao,JianguoXu,SuhongYu,ZhenhuaLiu,LeeJia*.TheuniquepharmacologicalcharacteristicsofMifepristone(RU486):fromterminatingpregnancytopreventingcancermetastasis.MedicinalResearchReviews,DOI10.1002/med,2014.(IF=9.583)
4)HaijunChen*,XiaobinZhou,YuGao,BiyuanZheng,FengxiangTang,JiandongHuang*.Recentprogressindevelopmentofnewsonosensitizersforsonodynamiccancertherapy.DrugDiscoveryToday,doi:10.1016/j.drudis.2014.01.010,2014.(IF=6.551)
5)YushengLu1,TingYu1,HaiyanLiang1,JichuangWang1,JingjingXie1,JingweiShao1,YuGao1,SuhongYu1,ShumingChen2,LieWang2&LeeJia1.Nitricoxideinhibitshetero-adhesionofcancercellstoendothelialcells:restrainingcirculatingtumorcellsfrominitiatingmetastaticcascade.SciRep.2014Mar11;4:4344.doi:10.1038/srep04344.
6)Jian-ZhongChena,b,1,Ji-ChuangWanga,1,YuGaoa,Rong-JieZengb,ZhouJianga,Ye-WeiZhua,Jing-WeiShaoa,LeeJiaa,?AnovelUPLC/MS/MSmethodforrapiddeterminationofmetapristoneinratplasma,anewcancermetastasischemopreventiveagentderivedfrommifepristone(RU486).JournalofPharmaceuticalandBiomedicalAnalysis95(2014)158–163
2013年以前
1.YuGao1,YuChen1,XiufengJi1,XinyuHe,QiYin,ZhiwenZhang,JianlinShi,YapingLi.Controlledintracellularreleaseofdoxorubicininmultidrugresistantcancercellsbytuningtheshell-poresizesofmesoporoussilicananoparticles.ACSNano5(2011)9788-9798.(IF=10.774)
2.YuGao,LingliChen,ZhiwenZhang,WangwenGu,YapingLi.Reversalofmultidrugresistancebyreduction-sensitivelinearcationicclickpolymer/iMDR1-pDNAcomplexnanoparticles.Biomaterials32(2011)1738-1747.(IF=7.404)
3.QianjunHe1,YuGao1(co-firstauthor),LingxiaZhang,ZhiwenZhang,FangGao,XiufengJi,YapingLi,JianlinShi.ApH-responsivemesoporoussilicananoparticles-basedmulti-drugdeliverysystemforovercomingmulti-drugresistance.Biomaterials32(2011)7711-7720.(IF=7.404)
4.YuGao1,WangwenGu1,LingliChen,ZhenghongXu,YapingLi.Theroleofdaidzein-loadedstericallystabilizedsolidlipidnanoparticlesintherapyforcardio-cerebrovasculardiseases.Biomaterials29(2008)4129-4136.(IF=7.404)
5.JiananShen1,QianjunHe1,YuGao1(co-firstauthor),JianlinShi,YapingLi.Mesoporoussilicananoparticlesloadingdoxorubicinreversemultidrugresistance:performanceandmechanism.Nanoscale3(2011)4314-4322.(IF=5.914)
6.YuGao1,RongfuYang1,ZhiwenZhang,LingliChen,ZuyueSun,YapingLi.Solidlipidnanoparticlesreducesystemictoxicityofdocetaxel:performanceandmechanisminanimal.Nanotoxicology5(2011)636-649.(IF=5.758)
7.YuGao1,WangwenGu1,LingliChen,ZhenghongXu,YapingLi.Amultifunctionalnanodeviceasnon-viralvectorforgenedelivery:invitrocharacteristicsandtransfection.JournalofControlledRelease118(2007)381-388.(IF=5.732)
8.YuGao,LingliChen,ZhiwenZhang,WangwenGu,YapingLi.Linearcationicclickpolymerforgenedelivery:synthesis,biocompatibility,andinvitrotransfection.Biomacromolecules11(2010)3102-3111.(IF=5.479)
9.YuGao,ZhiwenZhang,LingliChen,WangwenGu,YapingLi.Synthesisof6-N,N,N-trimethyltriazolechitosanvia“clickchemistry”andevaluationforgenedelivery.Biomacromolecules10(2009)2175-2182.(IF=5.479)
10.YuGao,QiYin,LingliChen,ZhiwenZhang,YapingLi.Linearcationicclickpolymers/DNAnanoparticles:invitrostructure-activityrelationshipandinvivoevaluationforgenedelivery.BioconjugateChemistry22(2011)1153-1161.(IF=4.930)
11.YuGao1,LingliChen1,WangwenGu,YongXi,LipingLin,YapingLi.Targetednanoassemblyloadedwithdocetaxelimprovesintracellulardrugdeliveryandefficacyinmurinebreastcancermodel.MolecularPharmaceutics5(2008)1044-1054.(IF=4.782)
12.XiufengJi1,YuGao1(co-firstauthor),LingliChen,ZhiwenZhang,YihuiDeng,YapingLi.Nanohybridsystemsofnon-ionicsurfactantinsertingliposomesloadingpaclitaxelforreversalofmultidrugresistance.InternationalJournalofPharmaceutics422(2012)390-397.(IF=3.350)
13.YuGao1,PengfeiXu1,LingliChen,YapingLi.ProstaglandinE1encapsulatedintolipidnanoparticlesimprovesitsanti-inflammatoryeffectwithlowside-effect.InternationalJournalofPharmaceutics387(2010)263-271.(IF=3.350)
14.YuGao,WangwenGu,LingliChen,YapingLi.ChitosanN-betainates/DNAself-assemblynanoparticlesforgenedelivery:invitrouptakeandtransfectionefficiency.InternationalJournalofPharmaceutics371(2009)156-162.(IF=3.350)
15.YuGao,ZhenghongXu,ChenShangwei,WangwenGu,LingliChen,YapingLi.Arginine-chitosan/DNAself-assemblenanoparticlesforgenedelivery:invitrocharacteristicsandtransfectionefficiency.InternationalJournalofPharmaceutics359(2008)241-246.(IF=3.350)
16.YuChen,YuGao,HangrongChen,DepingZeng,YapingLi,YuanyiZheng,FaqiLi,XiufengJi,XiaWang,FengChen,QianjunHe,LinlinZhang,JianlinShi.Engineeringinorganicnanoemulsions/nanoliposomesbyfluoride-silicachemistryforefficientdelivery/co-deliveryofhydrophobicagents.AdvancedFunctionalMaterials22(2012)1586-1597.(IF=10.179)
17.QianjunHe,YuGao,LingxiaZhang,WenboBu,HangrongChen,YapingLi,JianlinShi.One-potself-assemblyofmesoporoussilicananoparticle-basedpH-responsiveanti-cancernanodrugdeliverysystem.JournalofMaterialsChemistry21(2011)15190-15192.(IF=5.968)
18.QiYin,YuGao,ZhiwengZhang,PengchengZhang,YapingLi.Bioreduciblepoly(β-aminoesters)/shRNAcomplexnanoparticlesforefficientRNAdelivery.JournalofControlledRelease151(2011)35-44.(IF=5.732)
19.YongxinYang,YuGao,LingliChen,YongzhuoHuang,YapingLi.DownregulationofsurvivinexpressionandenhancedchemosensitivityofMCF-7cellstoadriamycinbyPDMAE/survivinshRNAcomplexnanoparticles.InternationalJournalofPharmaceutics405(2011)188-195.(IF=3.350)
20.HuihuiBu,YuGao,YapingLi.Overcomingmultidrugresistance(MDR)incancerbynanotechnology.Sci.ChinaSer.B-Chem.53(2010)2226-2232.(IF=1.199)
21.QianjunHe,ZhiwenZhang,YuGao,JianlinShi,YapingLi.Intracellularlocalizationandcytotoxicityofsphericalmesoporoussilicanano-andmicroparticles.Small5（2009）2722-2729.(IF=8.349)
22.WangwenGu,ZhenghongXu,YuGao,LingliChen,YapingLi.Transferrin-mediatedPEGylatednanoparticlesfordeliveryofDNA/PLLcomplexes.Nanotechnology17(2006)4148-4155.(IF=3.979)
23.ZhenghongXu,LingliChen,WangwenGu,YuGao,LipingLin,ZhiwenZhang,YongXi,YapingLi.Theperformanceofdocetaxel-loadedsolidlipidnanoparticlestargetedtohepatocellularcarcinoma.Biomaterials30(2009)226-232.(IF=7.404)
24.YongxinYang,ZhenghongXu,JinguiJiang,YuGao,WangwenGu,YapingLi.Poly(imidazole/DMAEA)phosphazene/DNAself-assemblednanoparticlesforgenedelivery:synthesisandinvitrotransfection.JournalofControlledRelease127(2008)273-279.(IF=5.732)
25.ZhenghongXu,WangwenGu,LingliChen,YuGao,ZhiwenZhang,YapingLi.Asmartnanoassemblyconsistingofacid-labilevinyletherPEG-DOPEandprotamineforgenedelivery:preparationandinvitrotransfection.Biomacromolecules9(2008)3119-3126.(IF=5.479)
26.YongxinYang,ZhenghongXu,ShangweiChen,YuGao,WangwenGu,LingliChen,YuanyingPei,YapingLi.Histidylatedcationicpolyorganophosphazene/DNAself-assemblednanoparticlesforgenedelivery.InternationalJournalofPharmaceutics353(2008)277-282.(IF=3.350)
27.PengchengZhang,LingliChen,WangwenGu,ZhenghongXu,YuGao,YapingLi.Invitroandinvivoevaluationofdonepezil-sustainedreleasemicroparticlesforthetreatmentofAlzheimer’sdisease.Biomaterial28(2007)1882-1888.(IF=7.404)
获奖情况
☆2010年中国科学院院长奖优秀奖
☆中科院2009-2010学年“三好学生标兵”
☆2009年上海药学科技一等奖（第三完成人）
☆中科院2008-2009学年“三好学生”
☆2007年度中国科学院地奥奖学金二等奖
☆中科院2006-2007学年“三好学生”
☆2005年福州大学“优秀毕业生”
其他
