姓名：陈海军
性别：男
职称：副教授
学历：博士
职务：
电话：**
专业：药物化学
电子邮件：chenhaij@gmail.com
研究方向：药物设计与合成
教育工作经历
☆2003.09–2008.07中国科学院上海药物研究所博士
专业：药物化学
☆1999.09–2003.07福州大学理学和工学双学士学位
专业：理科化学，生物工程
工作经历
☆2013.03-至今福州大学化学化工学院副教授
☆2011.03–2013.02美国德州大学加尔维斯顿医学分部博士后
☆2008.06–2011.02ShangPharma（尚华医药）课题组长
教学简介
科研简介
社会兼职
科研项目
代表性论文
2.Chen,H.;Wild,C.;Zhou,X.;Ye,N.;Cheng,X.;Zhou,J.RecentAdvancesintheDiscoveryofSmallMoleculesTargetingExchangeProteinsDirectlyActivatedbycAMP(EPAC).JMedChem2014,inpress.
3.Chen,H.;Tsalkova,T.;Chepurny,O.G.;Mei,F.C.;Holz,G.G.;Cheng,X.;Zhou,J.IdentificationandcharacterizationofsmallmoleculesaspotentandspecificEPAC2antagonists.JMedChem2013,56,952-962.
4.Chen,H.;Yang,Z.;Ding,C.;Chu,L.;Zhang,Y.;Terry,K.;Liu,H.;Shen,Q.;Zhou,J.DiscoveryofO-AlkylaminoTetheredNiclosamideDerivativesasPotentandOrallyBioavailableAnticancerAgents.ACSMedChemLett2013,4,180-185.
5.Chen,H.;Yang,Z.;Ding,C.;Chu,L.;Zhang,Y.;Terry,K.;Liu,H.;Shen,Q.;Zhou,J.Fragment-baseddrugdesignandidentificationofHJC0123,anovelorallybioavailableSTAT3inhibitorforcancertherapy.EurJMedChem2013,62,498-507.
6.Chen,H.;Wang,C.Z.;Ding,C.;Wild,C.;Copits,B.;Swanson,G.T.;Johnson,K.M.;Zhou,J.AcombinedbioinformaticsandchemoinformaticsapproachfordevelopingasymmetricbivalentAMPAreceptorpositiveallostericmodulatorsasneuroprotectiveagents.ChemMedChem2013,8,226-230.
7.Chen,H.;Ding,C.;Wild,C.;Liu,H.;Wang,T.;White,M.A.;Cheng,X.;Zhou,J.EfficientSynthesisofESI-09,ANovelNon-cyclicNucleotideEPACAntagonist.TetrahedronLett2013,54,1546-1549.
8.Chen,H.;Tsalkova,T.;Mei,F.C.;Hu,Y.;Cheng,X.;Zhou,J.5-Cyano-6-oxo-1,6-dihydro-pyrimidinesaspotentantagoniststargetingexchangeproteinsdirectlyactivatedbycAMP.BioorgMedChemLett2012,22,4038-4043.
9.Chen,H.J.;Liu,Y.;Wang,L.N.;Shen,Q.;Li,J.;Nan,F.J.DiscoveryandstructuraloptimizationofpyrazolederivativesasnovelinhibitorsofCdc25B.BioorgMedChemLett2010,20,2876-2879.
10.Chen,H.J.;Wang,W.L.;Wang,G.F.;Shi,L.P.;Gu,M.;Ren,Y.D.;Hou,L.F.;He,P.L.;Zhu,F.H.;Zhong,X.G.;Tang,W.;Zuo,J.P.;Nan,F.J.Rationaldesignandsynthesisof2,2-bisheterocycletandemderivativesasnon-nucleosidehepatitisBvirusinhibitors.ChemMedChem2008,3,1316-1321.
11.Yang,L.;Shi,L.P.;Chen,H.J.;Tong,X.K.;Wang,G.F.;Zhang,Y.M.;Wang,W.L.;Feng,C.L.;He,P.L.;Zhu,F.H.;Hao,Y.H.;Wang,B.J.;Yang,D.L.;Tang,W.;Nan,F.J.;Zuo,J.P.Isothiafludine,anovelnon-nucleosidecompound,inhibitshepatitisBvirusreplicationthroughblockingpregenomicRNAencapsidation.ActaPharmacolSin2014,inpress.
12.Gao,Y.;Xie,J.;Chen,H.;Gu,S.;Zhao,R.;Shao,J.;Jia,L.Nanotechnology-basedintelligentdrugdesignforcancermetastasistreatment.BiotechnolAdv2014,inpress.
13.Wang,J.;Chen,J.;Wan,L.;Shao,J.;Lu,Y.;Zhu,Y.;Ou,M.;Yu,S.;Chen,H.;Jia,L.Synthesis,SpectralCharacterization,andInVitroCellularActivitiesofMetapristone,aPotentialCancerMetastaticChemopreventiveAgentDerivedfromMifepristone(RU486).AAPSJ2014,inpress.
14.Ding,C.;Zhang,Y.;Chen,H.;Wild,C.;Wang,T.;White,M.A.;Shen,Q.;Zhou,J.OvercomingsyntheticchallengesoforidoninA-ringstructuraldiversification:regio-andstereoselectiveinstallationofazidesand1,2,3-triazolesattheC-1,C-2,orC-3position.OrgLett2013,15,3718-3721.
15.Ding,C.;Zhang,Y.;Chen,H.;Yang,Z.;Wild,C.;Chu,L.;Liu,H.;Shen,Q.;Zhou,J.Novelnitrogen-enrichedoridoninanalogueswiththiazole-fusedA-ring:protectinggroup-freesynthesis,enhancedanticancerprofile,andimprovedaqueoussolubility.JMedChem2013,56,5048-5058.
16.Ding,C.;Zhang,Y.;Chen,H.;Yang,Z.;Wild,C.;Ye,N.;Ester,C.D.;Xiong,A.;White,M.A.;Shen,Q.;Zhou,J.OridoninRingA-BasedDiverseConstructionsofEnoneFunctionality:IdentificationofNovelDienoneAnaloguesEffectiveforHighlyAggressiveBreastCancerbyInducingApoptosis.JMedChem2013.
17.Almahariq,M.;Tsalkova,T.;Mei,F.C.;Chen,H.;Zhou,J.;Sastry,S.K.;Schwede,F.;Cheng,X.AnovelEPAC-specificinhibitorsuppressespancreaticcancercellmigrationandinvasion.MolPharmacol2013,83,122-128.
18.Wang,W.L.;Chen,H.J.;Ma,W.P.;Gu,M.;Fan,M.Z.;Li,J.Y.;Feng,B.;Nan,F.J.SynthesisandantiviralactivityofconformationalanaloguesofleucamideA.Molecules2012,17,14522-14530.
19.Wang,W.L.;Yang,D.L.;Gao,L.X.;Tang,C.L.;Ma,W.P.;Ye,H.H.;Zhang,S.Q.;Zhao,Y.N.;Xu,H.J.;Hu,Z.;Chen,X.;Fan,W.H.;Chen,H.J.;Li,J.Y.;Nan,F.J.;Li,J.;Feng,B.1H-2,3-dihydroperimidinederivatives:anewclassofpotentproteintyrosinephosphatase1Binhibitors.Molecules2013,19,102-121.
20.Wan,J.;Zhu,Y.N.;Feng,J.Q.;Chen,H.J.;Zhang,R.J.;Ni,J.;Chen,Z.H.;Hou,L.F.;Liu,Q.F.;Zhang,J.;Yang,L.;Tang,W.;Yang,Y.F.;Nan,F.J.;Zhao,W.M.;Zuo,J.P.PeriplocosideA,apregnaneglycosidefromPeriplocasepiumBge,preventsconcanavalinA-inducedmicehepatitisthroughinhibitingNKT-derivedinflammatorycytokineproductions.IntImmunopharmacol2008,8,1248-1256.
获奖情况
☆2008年中国科学院“优秀毕业生”
☆中科院2007-2008学年“三好学生”
☆2003年福州大学“优秀毕业生”
其他
