姓名
黄义德


性别
男

职称学位
副教授、博士

联系方式


e-mail
ydhuang@fjnu.edu.cn




个人简介：黄义德，副教授，硕士生导师。

教育经历：1995年福建师范大学生物教育本科毕业，2001年获理学硕士，专业微生物学与生物化学，2005-2008年在福建农林大学攻读博士学位，专业生物化学与分子生物学。

工作经历：1995-2001年，福建师大新技术开发总公司任助工，工程师。2002年至今，福建师大生命科学院讲师、副教授。其间分别到美国北亚利桑那大学（Northern Arizona University）和英国爱丁堡大学（University of Edinburgh）癌症研究中心进修学习。

教学：现承担 “分子生物学”、“分子生物学实验”“生化分离技术导论”等教学，省级“分子生物学”精品课程主讲教师之一。获福建省高等学校优秀教学成果奖二等奖2项；获学校2013年度本科课堂教学优秀奖；2011年指导“挑战杯”全国大学生课外学术科技作品竞赛获全国三等奖。编著出版《分子生物学》和《分子生物学实验》2部教材，《分子生物学》参编；《分子生物学实验》主编。

硕士生招生方向：细胞生物学、发育生物学

研究方向：
(1)毕赤酵母（Pichia pastoris）表达系统研究
主要研究工作：毕赤酵母表达外源蛋白时细胞生理化学变化的分子机制、毕赤酵母提高外源蛋白的工程化改造、利用毕赤酵母表达系统生产活性蛋白和小分子化合物。
（2）癌症疾病研究
主要研究工作：癌症疾病发生发展的相关分子机制、抗体药物对癌症疾病的治疗和早期诊断。
（3）新型光动力治疗材料的开发与生物应用
主要研究工作：新型光动力治疗材料的开发、光动力治疗材料在抗肿瘤和抗菌方向的应用。
研究论文:
1.Xiaohua Li, Yong Fan, Qiong Lin, Jianxiong Luo, Yide Huang, Yuwang Bao & Liyu Xu. Expression of chromogranin A-derived antifungal peptide CGA-N12 in Pichia pastoris. Bioengineered. 2020, 11(1): 318-327.
2.Yide Huang*, Yafei Zhang, Suhuan Li, Ting Lin, Jingwen Wu& Yao Lin*. Screening for functional IRESes using α-complementation system of β-galactosidase in Pichia pastoris. Biotechnol Biofuels.2019 Dec 27;12:300. doi: 10.1186/s13068-019-1640-3.
3.Xiuqin Chen, Qiumei Guo, Shiqing Dong, Jianling Chen, Shusen Xie, Dongdong Ma,Limin Chen, Hongqin Yang, Yide Huang,*and Yiru Peng*Distribution, Trafficking, and in Vitro Photodynamic Therapy Efficacy of Cholesterol Silicon(IV) Phthalocyanine and Its Nanoparticles in Breast Cancer Cells. ACS Applied Bio Materials. 2019. DOI: 10.1021/acsabm.9b00909
4.Dongdong Ma, Xiuqin Chen, Yuhua Wang, Qiumei Guo, Qiuhao Ye, Ruotao Guo Shuanghuang Xiao, Qing Ye, Yide Huang^?,Yiru Peng^?. Benzyl ester dendrimer silicon phthalocyanine based polymeric nanoparticle for in vitro photodynamic therapy of glioma. Journal of Luminescence 207 (2019) 597–601.
5.Chen X, Wu S, Ma D, Chen J, Guo Q, Han X, Chen K, Yang H, Huang Y^?,Peng Y^?. A polyfluoroalkyl substituted phthalocyanine based supramolecular light switch for photothermal and photodynamic antibacterial activity against Escherichia coli.Chem Commun (Camb). 2018 Nov 22;54(94):13279-13282. doi: 10.1039/c8cc06071a.
6.Huang Y,Long Y, Li S, Lin T, Wu J, Zhang Y, Lin Y. Investigation on the processing and improving the cleavage efficiency of furin cleavage sites in Pichia pastoris.Microb Cell Fact. 2018 Nov 8;17(1):172. doi: 10.1186/s12934-018-1020-x.
7.Kuizhi Chen, Di Zeng, Ying Huang, Yawen Chen, Yide Huang, Shusen Xie, Yiru Peng & Qing Ye. Photophysical properties of pyridyloxy phthalocyanine encapsulated in nanoparticles. Spectroscopy letters, 2018 Jun; DOI: 10.1080/**.2018.**
8.Huang Y,Lin M, Chen X, Huang C, Zhang X, Chen L, Wu K, Chen Y, Zhu Y, Lin Y.Evaluation of the prognostic and physiological functions of death associated protein kinase 1 in breast cancer. Oncol Lett. 2018 Jun;15(6):8261-8268.
9.Huang Y,Zhang Y, Ge L, Lin Y, Kwok HF. The Roles of Protein Tyrosine Phosphatases in Hepatocellular Carcinoma.Cancers (Basel). 2018 Mar 20;10(3). pii: E82. doi: 10.3390/cancers**.
10.Jiang N, You M, Wang Y, Huang Y, Xie S, Lin Y, Yang H. Probing the biophysical properties of tumor cells during mitosis by atomic force microscopy.biomech Model Mechanobiol. 2018 Mar 17. doi: 10.1007/s10237-018-1012-0.
11.Xiao Y, Meng C, Lin J, Huang C, Zhang X, Long Y, Huang Y, Lin Y. Ouabain targets the Na+/K+-ATPase α3isoform to inhibit cancer cell proliferation and induce apoptosis.Oncol Lett. 2017 Dec;14(6):6678-6684. doi: 10.3892/ol.2017.7070. Epub 2017 Sep 26
12.Zhu Y, Li S, Wang Q, Chen L, Wu K, Huang Y,Chen X, Lin Y. Quantitative and correlation analysis of the DNA methylation and expression of DAPK in breast cancer. Peer J, 2017 5: 1-10 (doi:10.7717/peerj.3084)
13.Xiao Y, Yan W, Guo L, Meng C, Li B, Neves H, Chen PC, Li L, Huang Y, Kwok HF, Lin Y. Digitoxin synergizes with sorafenib to inhibit hepatocelluar carcinoma cell growth without inhibiting cell migration. Mol Med Rep. 2017 15(2):941-947
14.Yu X, Lin T, Lv H, Pan S, Wu S, Zeng D, Jiang Y, Wang Y, Yang H, Huang Y*, Peng Y*. Photophysical properties of catechol axially substituted tetra-α-(pentyloxy) titanium(IV) phthalocyanine. Proc. of SPIE. 2016 10024: 100243P-1-100243P-5.
15.Huang Y, Yu H, Lv H, Zhang H, Ma D, Yang H, Xie S, Peng Y. Triblock copolymers encapsulated poly (aryl benzyl ether) dendrimer zinc(II) phthalocyanine nanoparticles for enhancement in vitro photodynamic efficacy. Photodiagnosis Photodyn Ther. 2016;16:124-131
16.Huang Y,Zhang SD, McCrudden C, Chan KW, Lin Y, Kwok HF. The prognostic significance of PD-L1 in bladder cancer.Oncol Rep. 2015 33(6):3075-84.
17.Huang Y, Yang Y, Jiang M, Lin M, Li S, Lin Y Immortalization and characterization of human dental mesenchymal cells. J Dent. 2015 43(5):576-82.
18.Huang Y,Ma D, Pan S, Lin P, Lin Y, Yang H, Peng Y. Comparative study of aluminum phthalocyanine incorporating into two types of block copolymer: photophysical property, size, and in vitro photodynamic therapy efficacy. J Nanopart Res. 2015 17:41-50.
19.Huang Y, Zhen R, Jiang M, Yang J, Yang Y, Huang Z, Lin Y. Development of all-in-one multicistronic Tet-On lentiviral vectors for inducible co-expression of two transgenes. Biotechnol Appl Biochem. 2015；62(1):48-54.
20.He Y, Zheng L, Huang Y, Lin P, Yang H, Peng Y. Spectroscopic studies of the interaction between tetra-substituted aluminum phthalocyanines and bovine serum albumin. Optics in Health Care and Biomedical Optics VI, doi: 10.1117/12.**, Proc. of SPIE Vol. 9268 92682A
21.Huang Y, Chen L, Guo L, Hupp T, Lin Y. Evaluating DAPK as a therapeutic target. Apoptosis (2014) 19:371–386
22.Huart AS,Saxty B,Merritt A,Nekulova M,Lewis S,Huang Y,Vojtesek B,Kettleborough C,Hupp TR. A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novel activator of the p53 pathway. Bioorg Med Chem Lett.2013, 23(20):5578-85.
23.Huang Y,Zhen B,Lin Y,Cai Y,Lin Z,Deng C,Zhang YExpression of Codon Optimized Human Bone Morphogenetic Protein 4 in Pichia pastoris Biotechnol Appl Biochem.2014，61（2）：175-183.
24.Mingfeng Zhang, Jueping Shi, Yide Huang, and Laijun Lai, Expression of canonical WNT/β-CATENIN signaling components in the developing human lung. BMC Dev Biol. 2012; 12: 21.