? 姓名： 李煌元 所在单位： 公共卫生学院预防医学系 性别： 男 主要研究方向： 分子神经毒理学表观遗传毒理学 职称： 教授 办公电话： 0591-22862527 学历： 研究生 电子邮箱： fmulhy@163.com 硕博导： 硕导、博导 ? 个人简介：李煌元，男，1973年3月生，医学博士，教授，博士生导师，哈佛医学院国家公派访问学者，1997年于福建医科大学预防医学专业获医学学士学位、2003年于福建医科大学流行病与卫生统计学专业获医学硕士学位、2006年于华中科技大学劳动卫生与环境卫生学专业获医学博士学位。现任福建医科大学公共卫生学院副院长，2002年获得福建医科大学优秀青年教师和福州市优秀青年教师称号，2006年入选福建医科大学青年骨干教师培养对象，2007年入选毒理学省级教学团队，2009年入选福建医科大学学科带头人培养对象，2011年度入选福建省高等学校新世纪优秀人才支持计划。一直从事公共卫生与预防医学的教学与科研工作，主要从事分子神经毒理学、表观遗传毒理学和慢性病流行病学研究,重点在“Nrf2/ARE信号通路和表观遗传修饰改变在环境神经毒物致神经损害中的作用及机制”等领域进行深入的专门研究。先后主持国家自然科学基金项目3项、福建省杰出青年科学基金1项，福建省自然科学基金项目1项、省高校新世纪优秀人才支持计划1项、福建省卫生系统中青年骨干人才培养项目（重点项目）1项等国家、省厅各级各类科研课题多项。近年来公开发表论文60余篇，其中SCI论文21篇，第一作者或通讯作者12篇（2篇发表于毒理学IF排名前10%杂志）。 教学工作：面向本科生主讲《公共卫生概论》、《毒理学基础》、《食品毒理学》、《职业卫生与职业医学》和《卫生学》（海外全英语），面向研究生主讲《科研项目设计与申报》、《现代毒理学基础》、《现代毒理学实验技术原理与方法》和《临床药物毒理学基础》等课程。为《公共卫生概论》、《海西公共卫生热点问题》和《卫生学》（海外全英语）课程负责人。 科研成果： 作为主要参与者获得福建省科学技术奖三等奖1项（2009-3-007-4），福建省教学成果奖一等奖1项（2014062-2），国家级预防医学特色专业等7项教学质量工程项目（成果）。 发表论文（代表作）： [1]LI Huangyuan(*), WU Siying, WANG Zhangjing, LIN Wei, ZHANG Chenzi, HUANG Bin. Neuroprotective effects of tert-butylhydroquinone on paraquat-induced dopaminergic cell degeneration in C57BL/6 mice and in PC12 cells. Archives of Toxicology,2012, 86(11):1729-1740（SCI）(Corresponding author) [2]LI Huangyuan(*), WU Siying, LIN Wei, YOU Junyi, ZHOU Wenhua, SHI Nian.NF-E2-related factor 2 activation in PC12 cells: its protective role in manganese-induced damage. Archives of Toxicology,2011, 85:901-910（SCI）(Corresponding author) [3]LI Huangyuan(*), WU Siying, SHI Nian, LIAN Shuangqing, LIN Wei. Nrf2/HO-1 pathway activation by manganese is associated with reactive oxygen species and ubiquitin-proteasome pathway, not MAPKs signaling. Journal of Applied Toxicology,2011,31:690-697（SCI）(Corresponding author) [4]LI Huangyuan, WU Siying, MA Qiang, SHI Nian. The pesticide deltamethrin increases free radical production and promotes nuclear translocation of the stress response transcription factor Nrf2 in rat brain. Toxicology and Industrial Health ,2011, 27(7):579-590.（SCI） [5]LI Huangyuan, ZHONG Yufang, WU Siying, SHI Nian. NF-E2 related factor 2 activation and Heme oxygenase-1 induction by tert-butylhydroquinone protect against deltamethrin mediated oxidative stress in PC12 cells. Chemical Research in Toxicology,2007,20 (9):1242–1251.（SCI） [6]LI Huangyuan, WU Siying, SHI Nian. Transcription factor Nrf2 activation by deltamethrin in PC12 cells: involvement of ROS.Toxicology Letters, 2007,171(1-2):87-98.（SCI） [7]LI Huangyuan, WU Siying, SHI Nian. Effect of Glutathione Depletion on Nrf2/Are Activation by Deltamethrin in PC12 Cells. Archives of Industrial Hygiene and Toxicology,2013,64(1):87-97 (SCI) [8]LI Huangyuan, SHI Nian, WU Siying, ZHONG Yufang, MA Qiang. Deltamethrin-induced reactive oxygen species in PC12 cells and rats: role of N-acetyl-L-cysteine. Drug Metabolism Reviews,2006,38(Suppl.1):170.(abstract, SCI) [9]WU Siying, LIN Shaowei，LI Huangyuan(*)，CHAI Wenli，ZHANG Qiaohui，WU Yimai，ZHU Wei. A study on workplace violence and its effect on quality of life among medical professionals in China. Arch Environ Occup Health, 2014,69(2):81-88. （SCI）(Corresponding author) [10]WU Siying, LIN Shaowei, LI Huangyuan(*), CHAI Wenli, WANG Xiaorong.. A study on workplace violence and its effect on quality of life among medical professionals in China. Archives of Environmental and Occupational Health. 2012,55(11):1000-1008.（SCI）(Corresponding author) [11]WU Siying, LI Huangyuan(*),WANG Xiaorong, YANG Shujuan, QIU Hong. A comparison of the effect of work stress on burnout and quality of life between female nurses and female doctors. Archives of Environmental and Occupational Health, 2011, 66(4):193-200.（SCI）(Corresponding author) [12]WU Siying, LI Huangyuan(*),ZHU Wei, LIN Shaowei, CHAI Wenli, WANG Xiaorong. Effect of Work Stressors, Personal Strain, and Coping Resources on Burnout in Chinese Medical Professionals: a Structural Equation Model. Industrial Health. 2012,50(4):279-287.（SCI） (Corresponding author) [13]WU Siying, LI Huangyuan, YANG Shujuan, ZHU Wei, WANG Xiaorong. The mediating and moderating role of personal strain and coping resource in the relationship between work stressor and quality of life among Chinese nurses. International Archives of Occupational and Environmental Health,2012, 85:35-43. (SCI) [14]WU Siying, Wei ZHU, LI Huangyuan, YU Ignatius Tak-Sun, LIN Sihao, WANG Xiaorong, YANG Shujuan. Quality of Life and its influencing factors among medical professionals in China. International Archives of Occupational and Environmental Health,2010,83(7) :753-761.（SCI） [15]WU Siying, LI Huangyuan, ZHU Wei, LI Jian, WANG Xiaorong. A structural equation model relating work stress, coping resource and quality of life among Chinese medical professionals. American Journal of Industrial Medicine,2010,53(11):1170-1176.（SCI） [16]WU Siying, LI Huangyuan, TIAN Jun, ZHU Wei, LI Jian, WANG Xiaorong. Health-related quality of life and its main related factors among nurses in China. Industrial Health,2011;49(2):158-65.（SCI） [17]WU Siying, ZHU Wei, LI Huangyuan. Relationship between job burnout and occupational stress among doctors in China. Stress and Health,2008,24(2):143-149.（SCI） [18]WU Siying, LI Jian, WANG Mianzhen,WANG Zhiming,LI Huangyuan. Intervention on Occupational Stress among Teachers in the Middle Schools in China. Stress and Health,2006,22(5):329-336.（SCI） [19]LI Huangyuan, SHI Nian, ZHONG Yufang, LIU Linlin. Effects of deltamethrin on the activation or expression of Nrf2 and on the GCS-HS protein level in primary astrocytes with laser scanning confocal microscope. Journal of Nanjing Medical University, 2006,20(1):1-7.（in English） [20]ZHANG Wenchang, WU Zhiren, LI Huangyuan, EZAKI Tatsuo, KOJI Takehiko. Effects of Cadmium as a Possible Endocrine Disruptor upon the Serum Level of Sex Steroids and the Secretion of Gonadotropins from Pituitary in Adult Rats. Acta Med. Nagasaki,2002,47:53-56. (In English) 出版著作：主编《公共卫生导论》（郑州大学出版社），副主编专著《自由基毒理学》（人民卫生出版社)，参编《分子毒理学》（人民卫生出版社）、《毒理学基础》（人民卫生出版社）、《临床毒理学》（人民卫生出版社）、《职业卫生与职业医学》（科学出版社）、《预防医学基本技能训练实验教程》（人民卫生出版社）和《生殖健康学》（人民卫生出版社）教材，参编《中国医学百科全书》（毒理学分册）和《现代毒理学》（人民卫生出版社）等专著。 奖励情况：获第七届“福建省五四青年奖章”和“校优秀共产党员”荣誉称号。 学术活动：担任中国毒理学会神经毒理学专业委员会青年委员、中华预防医学会自由基预防医学专业委员会委员、中国环境诱变剂学会理事、福建省预防医学会理事、福建省预防医学会劳动卫生专业委员会常务委员、Journal of Environmental & Analytical Toxicology （OMICS Publishing Group, USA）编委、美国毒理学学会正式会员等，为多本SCI英文杂志审稿人。