个人简介：
陈敬华，男，1978年10月生，理学博士，教授，博士生导师，2001年于福州大学化学专业（理科化学基地班）获理学学士学位、2004年于福州大学分析化学专业业获理学硕士学位、2010年于福州大学分析化学专业获理学博士学位。曾任福建医科大学药学院副院长，现任福建医科大学发展规划办公室副主任，福建医科大学九三学社第三届委员会委员，福建省青年联合会第十二届委员会委员。先后主持国家自然科学基金青年和面上项目、福建省自然基金****项目、福建省自然基金面上项目、福建省科技计划重点项目、福建省高校****培育计划、福建省高等学校新世纪优秀人才支持计划、福建省卫生系统中青年骨干人才培养重点项目等课题，作为主要参与者参与并完成了两项国家863计划课题和多项国家自然科学基金。近年来在Analytical Chemistry、Biosensors and Bioelectronics、Chemistry Communications等SCI刊物发表研究论文110篇，其中自然指数期刊11篇，SCI收录90多篇；论文SCI他引次数1642次；已授权发明专利5项。
教学工作：
面向本科生主讲《仪器分析》、《卫生化学》、《分析化学》、《药物分析》，面向研究生主讲《高等药物分析》、《高级药学综合实验》等课程。
研究方向：
液体活检新技术研究：将DNA自组装、核酸适配体和DNA纳米机器与纳米材料以及多通道阵列式生物传感技术结合，构建便携式即时和床边检测设备，用于外泌体、循环肿瘤细胞、微小RNA等肿瘤标志物的检测。
食品、农产品及中药材安全分析与环境监测研究：将具有类似抗体功能的核酸适配体与纳米、光学、电化学等多种技术相结合，构建便携式设备，实现食品、农产品及中药材中真菌毒素、农药残留、重金属等现场快速检测。
外泌体多功能载药系统研究：将外泌体作为药物载体，包载纳米粒子、化疗药物、光敏剂、分子靶向药物或光热治疗药物等，实现超灵敏、高空间分辨的肿瘤多模态成像（MRI、CT、SPECT/CT、光声、荧光成像等），以及高效的肿瘤靶向治疗（化疗、光热、光动力治疗等）。并探索多种疗法（化疗、光热治疗、光动力治疗等）之间的协同增效机制，实现对肿瘤的协同治疗作用。
代表性论文：
1)Yaokun Xia, Wenhui He, Juan Li, Lupeng Zeng, Tingting Chen, Yijuan Liao, Weiming Sun, Jianming Lan, Shuangmu Zhuo, Jing Zhang*, Huanghao Yang*, Jinghua Chen*, Acridone Derivate Simultaneously Featuring Multiple Functions and Its Applications, Analytical Chemistry, 2019, 91(13): 8406-8414.
2) Yaokun Xia, Liangliang Wang, Juan Li, Xiangqi Chen, Jianming Lan, An Yan, Yun Lei, Sheng Yang*, Huang-Hao Yang*, and Jing-Hua Chen*, A Ratiometric Fluorescent Bioprobe Based on Carbon Dots and Acridone Derivate for Signal Amplification Detection Exosomal microRNA. Analytical Chemistry, 2018,90(15): 8969-8976.
3) Jing Zhang*, Liang-Liang Wang, Mei-Feng Hou, Li-Pei Luo, Yi-Juan Liao, Yao-Kun Xia, An Yan, Yun-Ping Weng, Lu-Peng Zeng, Jing-Hua Chen*, Label-free fluorescent and electrochemical biosensors based on defective Gquadruplexes. Biosensors and Bioelectronics, 2018, 118, 1-8.
4) Jing Zhang, Liang-Liang Wang, Mei-Feng Hou, Yao-Kun Xia, Wen-Hui He, An Yan, Yun-Ping Weng, Lu-Peng Zeng, Jing-Hua Chen*, A ratiometric electrochemical biosensor for the exosomal microRNAs detection based on bipedal DNA walkers propelled by locked nucleic acid modified toehold mediate strand displacement reaction, Biosensors and Bioelectronics, 2018, 102, 33-40.
5) Xiaosong Chen*, Jianming Lan, Yingxin Liu, Li Li, Liu Yan, Yaokun Xia, Fang Wu, Chunyan Li, Shirong Li, Jinghua Chen*, A paper-supported aptasensor based on upconversion luminescence resonance energy transfer for the accessible determination of exosomes, Biosensors and Bioelectronics, 2018, 102, 582-588.
6) Yaokun Xia, Mengmeng Liu, Liangliang Wang, An Yan, Wenhui He, Mei Chen, Jianming Lan, Jiaoxing Xu^b,c, Lunhui Guan^*, Jinghua Chen^*,A Visible and Colorimetric Aptasensor Based on DNA-capped Single-Walled Carbon Nanotubes for Detection of Exosomes, Biosensors and Bioelectronics, 2017, 92, 8-15.
7)Fang Wu, Mei Chen, Jianming Lan, Yaokun Xia, Mengmeng Liu, Wenhui He, Chunyan Li, Xiaosong Chen?, Jinghua Chen?，A universal locked nucleic acid-integrated X-shaped DNA probedesign for amplified fluorescence detection of single-nucleotide variant, Sensors and Actuators B, 2017, 241: 123-128.
8)Jing Zhang,Dong-Zhi Wu,Shu-Xian Cai,Mei Chen,Yao-Kun Xia,Fang Wu,Jing-Hua Chen*,An immobilization-free electrochemical impedance biosensor based on duplex-specific nuclease assisted target recycling for amplified detection of microRNA,Biosensors and Bioelectronics,2016, 75, 452-457.
9)Chunyan Li, Zhijing Liu, Shuxian Cai, FadiWen, DongzhiWu, Yingxin Liu, Fang Wu, Jianming Lan, Zhizhong Han, Jinghua Chen*, An electrochemicalmicroRNA biosensor based on protein p19 combining an acridone derivate as indicator and DNA concatamers for signal amplification, Electrochemistry Communications, 2015, 60:185-189.
10)Jing Zhang, Dongzhi Wu, QiuXiang Chen, Mei Chen, Yaokun Xia, Shuxian Cai, Xi Zhang, Fang Wu, Jinghua Chen*, Label-Free MicroRNA Detection based on Terbium and Duplex-Specific Nuclease Assisted Target Recycling.Analyst, 2015,140, 5082-5089.
11)Shuxian Cai,Guangwen Li,Xi Zhang,Yaokun Xia,Mei Chen, Dongzhi WuQiuxiang Chen,Jing Zhang*,JinghuaChen*，A signal-on fluorescent aptasensor based on single-stranded DNA-sensitized luminescence of terbium (III) for label-free detection of breast cancer cells. Talanta, 2015, 138:225-230.
12)Xianghui Li, Longjie Gan, Qishui Ou, Xi Zhang, Shuxian Cai, Dongzhi Wu, Mei Chen, Yaokun Xia, Jinghua Chen*, Bin Yang*, Enzyme-free and label-freefluorescencesensor for the detection of liver cancer related short gene.Biosensors and Bioelectronics, 2015, 66, 399-404.
13)Xi Zhang,Dongzhi Wu, Zhijing Liu, Shuxian Cai, Yanping Zhao, Mei Chen, Yaokun Xia, Chunyan Li, Jing Zhang^*and Jinghua Chen^*, An ultrasensitive Label-Free Electrochemical Biosensor for MicroRNA-21 Detection based on 2’-O-methyl modified DNAzyme and Duplex-Specific Nuclease Assisted Target Recycling.Chemical Communications, 2014, 50, 12375--12377.
14)Xi Zhang, Jing Zhang*, Dongzhi Wu, Zhijing Liu, Shuxian Cai, Mei Chen, Yanping Zhao, Chunyan Li, Huanghao Yang*, Jinghua Chen*, Ultraselective Electrochemiluminescence Biosensor Based on Locked Nucleic Acid Modified Toehold-Mediated Strand Displacement Reaction and Junction-probe,The Analyst,2014, 139,6109-6112.
15)Jianming Lan, Wenming Xu, Qiping Wan, Xi Zhang, Jia Lin, Jinghua Chen*, Jianzhong Chen*, Colorimetric determination of sarcosine in urine samples of prostatic carcinoma by mimic enzyme palladium nanoparticles, Analytica Chimica Acta 2014,825, 63-68.
16)Jinghua Chen, Xi Zhang, Shuxian Cai, Dongzhi Wu, Mei Chen, Shihua Wang^*, Jing Zhang^*,A Fluorescent Aptasensor based on DNA-Scaffolded Silver-Nanocluster for Ochratoxin A Detection, Biosensors and Bioelectronics, 2014,57, 226-231.
17)Jinghua Chen, Jia Lin, Xi Zhang, Shuxian Cai, Dongzhi Wu, Chunyan Li, Sheng Yang*, Jing Zhang*, Label-free fluorescent biosensor based on the target recycling and Thioflavin T-induced quadruplex formation for short DNA species of c-erbB-2 detection,Anal Chim Acta.2014, 817:42-47.
18)Jinghua Chen*, Xi Zhang, Shuxian Cai, Dongzhi Wu, Jia Lin, Chunyan Li, Jing Zhang *, Label-free electrochemical biosensor using home-made 10-methyl-3-nitro-acridone as indicator for picomolar detection of nuclear factor kappaB, Biosensors and Bioelectronics, 2014, 53, 12-17.
19)Hong C Y,Chen X,Li J,Chen J H*,Chen G,Yang H H*.Direct detection of circulating microRNAs in serum of cancer patients by coupling protein-facilitated specific enrichment and rolling circle amplification.Chem. Commun., 2014, 50 (25):3292-3295.
20)Jing Zhang, XiaoYan Wu, WeiJuan Yang, JingHua Chen*, FengFu Fu*, Ultra-sensitive electrochemical detection of single nucleotide polymorphisms based on an electrically controllable magnetic gold electrode,Chem. Commun.2013，49, 10, 996-998.
21)Cheng-YiHong, XianChen, TingLiu, JuanLi, Huang-HaoYang*, JingHua Chen*, Guo-NanChen Ultrasensitive electrochemical detection of cancer-associated circulating microRNA in serum samples based on DNA concatamers, Biosensors and Bioelectronics, 2013,50,15,132-136.
22)Jing Zhang, Xi Zhang, Guidi Yang, Jinghua Chen*, Shihua Wang, A signal-on fluorescent aptasensor based on Tb(3+) and structure-switching aptamer for label-free detection of Ochratoxin, Biosensors & bioelectronics.2013,15, 41, 704-709.
23)Xian Chen, Cheng-Yi Hong, Ya-Hui Lin, Jing-Hua Chen*, Guo-Nan Chen, Huang-Hao Yang*, Enzyme-free and label-free ultrasensitive electrochemical detection of human immunodeficiency virus DNA in biological samples based on long-range self-assembled DNA nanostructures,Analytical chemistry. 2012, 84(19): 8277-8283.
24)Jing Zhang, Jinghua Chen*, Xi Zhang, Zhigao Zeng, Mei Chen, Shihua Wang, An electrochemical biosensor based on hairpin-DNA aptamer probe and restrictionendonuclease for ochratoxin A detection, Electrochemistry Communications. 2012, 25(25): 5-7.
25)Jinghua Chen, Jing zhang, Juan Li, Huanghao Yang, Fengfu Fu, Guonan Chen, An ultrasensitive electrochemical biosensor for detection of DNA species related to oral cancer based on nuclease-assisted target recycling and amplification of DNAzyme,Chem.Commun., 2011, 47(28): 8004-8006.
26)Jing Zhang, QingLan Gao, PingPing Chen, JingHua Chen*, GuoNan Chen, FengFu Fu.A novel Tb³⁺-promoted G-quadruplex-hemin DNAzyme for the development of label-free visual biosensors. Biosensors and Bioelectronics, 2011, 26(10): 4053-4057.
27)Jinghua Chen, Jing Zhang, Juan Li, Huanghao Yang, Feng Fu Fu, Guonan Chen.An ultrahighly sensitive and selective electrochemical DNA sensor via nicking endonuclease assisted current change amplification. Chem. Commun., 2010,46(32): 5939-5941.
28)Jinghua Chen, Jing Zhang, HuangHao Yang*, Fengfu Fu, Guonan Chen*,A Strategy for Development of Electrochemical DNA Biosensor based on Site-specific DNA Cleavage of Restriction Endonuclease. Biosensors and Bioelectronics, 2010, 26(1): 144-148.
29)Jinghua Chen, Jing Zhang, Juan Li, Huanghao Yang*, Feng Fu Fu, Guonan Chen*. An Ultrasensitive Signal-On Electrochemical Aptasensor via Target-Induced Conjunction of Split Aptamer Fragments. Biosensors and Bioelectronics, 2010, 25(5): 996-1000.
30)Jinghua Chen, Jing Zhang, Kun Wang, Xinhua Lin, Liying Huang, Guonan Chen*, Electrochemical Biosensor for Detection of BCR/ABL Fusion Gene Using Locked Nucleic Acids on 4-Aminobenzenesulfonic Acid-Modified Glassy Carbon Electrode.Anal. Chem.,2008, 80(21): 8028-8034.
出版著作：副主编教材《仪器分析实验指导》，厦门大学出版社（ISBN 99）。
奖励情况：获得福建省科学技术二等奖2项（第二名，第四名）、福建省运盛青年科技奖1项（第一名）、福州市青年科技奖1项（第一名）、福建省优秀博士论文一等奖1项（第一名）、福建省自然科学优秀学术论文二等奖1项（第一名）、福建省自然科学优秀学术论文三等奖4项（第一名）。
学术活动：国际细胞外囊泡协会会员，中国化学会会员，《福建医科大学学报》编委，教育部科技发展中心科研基金和科技奖励评审专家，教育部学位与研究生教育评估专家，福建省安全生产事故隐患排查专家，《ACS Nano》、《Analytical Chemistry》、《Theranostics》、《Chemistry Communications》、《Biosensors and Bioelectronics》、《Nanoscale》、《Molecular Therapy-Nucleic Acids》、《Anal Chim Acta.》、《The Analyst》、《Microchimica Acta》、《Sensors & Actuators B. Chemical》、《Talanta》、《Journal of Hazardous Materials》、《Bioelectrochemistry》、《Electrochemistry Communications》、《Chinese Journal of Chemistry》、《Chinese Journal of Chemistry》、《中国科学：化学》等国际刊物特约审稿专家。