博、硕士研究生导师简介


个人简介：
Tae Ho Lee，男，理学博士，教授，博士生导师，1993年于韩国高丽大学生物学专业获理学学士学位，1995年于韩国高丽大学生物学专业获理学硕士学位，2003年于加拿大麦吉尔大学生物化学专业获理学博士学位，2009年于美国哈佛大学医学院贝斯以色列女执事医疗中心博士后流动站出站。2017年入选福建省“外专****”，2019年获福建省引进人才B类荣誉。现任福建医科大学基础医学院转化医学研究院教授，长期从事神经系统疾病研究，在衰老和阿尔兹海默病（AD）的研究领域已有许多重要的新发现，特别是关于Pin1及其调节因子DAPK1的研究，不仅揭示了新的病理机制，同时也为治疗AD提供新的策略。近年来，在Nature，Nat Cell Bio, Mol Cell, Nat Med, JCI等SCI收录的高影响因子期刊上发表学术论文30余篇。
科研工作：
获得国家自然科学基金面上项目和福建省自然科学基金面上项目，获得美国国立卫生研究院、美国老化研究联合会和AD协会等科研基金的支持。主要发现了与AD有关的DAPK1的新底物，构建了脑部特异性诱导型DAPK1过表达的转基因小鼠、研发了特异性和有效的DAPK1抑制剂。
发表论文：(10年内，第一作者或通讯作者)
1、Dongmei Chen and Tae Ho Lee^*.New oncogenic signalling pathway: EWS-Oct4 mediates bone and soft tissue tumourigenesis by activating fibroblast growth factor-4.The Federation of European Biochemical Societies Journal, 2019 (IF:4.739)
2、Nami Kim, Dongmei Chen, Xiao Zhen Zhou^*and Tae Ho Lee^*.Death-Associated Protein Kinase 1 Phosphorylation in Neuronal Cell Death and Neurodegenerative Disease.International Journal of Molecular Sciences, 2019, 20(13) (IF:4.183)
3、Dongmei Chen, Xiao Zhen Zhou^*and Tae Ho Lee^*. Death-Associated Protein Kinase 1 as a Promising Drug Target in Cancer and Alzheimer's Disease. Recent Patents on Anti-Cancer Drug Discovery, 2019, 14(2): 144-157 (IF:2.121)
4、Mi-Hyeon You, Byeong Mo Kim, Chun-Hau Chen, Michael J. Begley, Lewis C. Cantley and Tae Ho Lee^*. Death-associated protein kinase 1 phosphorylates NDRG2 and induces neuronal cell death. Cell Death and Differentiation, 2017, 24(2): 238-250 (IF:8.339)
5、Byeong Mo Kim^#, Mi-Hyeon You^#, Chun-Hau Chen, Jaehong Suh, Rudolph E. Tanzi and Tae Ho Lee^*. Inhibition of death-associated protein kinase 1 attenuates the phosphorylation and amyloidogenic processing of amyloid precursor protein. Human Molecular Genetics, 2016, 25(12): 2498-2513 (IF:5.34)
6、Tae Ho Lee^#, Sungha Park^#, Mi-Hyeon You, Ji-Hong Lim, Sang-Hyun Min, Byeong Mo Kim^*. A potential therapeutic effect of Saikosaponin C as a novel dual-target anti-Alzheimer agent. Journal of Neurochemistry, 2016, 136(6): 1232-1245 (IF:4.083)
7、Byeong Mo Kim, Mi-Hyeon You, Chun-Hau Chen, Seunghoon Lee, Yonggeun Hong, Adi Kimchi, Xiao Zhen Zhou, and Tae Ho Lee^*. Death-associated protein kinase 1 plays a critical role in aberrant tau protein regulation and function. Cell Death & Disease, 2014, 5: e1237 (IF:5.965)
8、Tae Ho Lee, Jihoon Chang, Byeong Mo Kim^*. Saikosaponin C inhibits lipopolysaccharide-induced apoptosis by suppressing caspase-3 activation and subsequent degradation of focal adhesion kinase in human umbilical vein endothelial cells. Biochemical and Biophysical Research Communications,2014, 445(3): 615-621 (IF:2.472)
9、Chun-Hau Chen^#, Che-Chang Chang^#, Tae Ho Lee^#, ManLi Luo, Pengyu Huang, Pei-Hsin Liao, Shuo Wei, Fu-An Li, Ruey-Hwa Chen, Xiao Zhen Zhou, Hsiu-Ming Shih and Kun Ping Lu^*. SENP1 deSUMOylates and regulates Pin1 protein activity and cellular function. Cancer Research, 2013, 73(13): 3951-3962 (IF:9.122)
10、Tae Ho Lee^#, Lucia Pastorino^#and Kun Ping Lu^*. Peptidyl-prolylcis-trans isomerase Pin1 in aging, cancer and Alzheimer’s disease. Expert Reviews in Molecular Medicine, 2011, 13: e21 (IF:4.405)
11、Tae Ho Lee^#, Chun-Hau Chen^#, Futoshi Suizu, Pengyu Huang, Cordelia Schiene-Fischer, Sebastian Daum, Yan Jessie Zhang, Alison Goate, Ruey-Hwa Chen, Xiao Zhen Zhou and Kun Ping Lu^*. Death associated protein kinase 1 phosphorylates Pin1 and inhibits its prolylisomerase activity and cellular function. Molecular Cell, 2011, 42(2): 147-159 (IF:14.714)
12、Tae Ho Lee, Adrian Tun-Kyi, Rong Shi, Jormay Lim, Christina Soohoo, Greg Finn, Martin Balastik, Lucia Pastorino, Gerburg Wulf, Xiao Zhen Zhou^*and Kun Ping Lu^*. Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance. Nature Cell Biology, 2009, 11(1): 97-105 (IF:20.06)


奖励情况：
在AD的研究中获得多个奖项，包括美国国家卫生研究院独立之路奖、阿尔兹海默病协会研究新人奖、美国联邦老化研究所研究新人奖、马萨诸塞州阿尔兹海默病研究中心奖、BrightFocus基金会阿尔兹海默病研究奖、阿尔兹海默病协会研究基金奖，并入选福建省“外专****”和福建省引进人才B类等荣誉。
学术活动：
新英格兰生物科学学会会员、美国老年学会会员、美国癌症研究协会会员、国际阿尔兹海默病协会会员、神经科学学会会员，参与《Journal of Biological Chemistry》、《Oncogene》、《Human Molecular Genetics》、《Cell Biology International》、《Experimental and Therapeutic Medicine》、《Biochemical Journal》、《Archives of Pharmacal Research》、等期刊以及阿尔兹海默病协会基金的审稿。