硕士研究生导师简介


个人简介：
王继闯，男，1985年10月出生，中共党员，博士。2015年10月来校工作，于2015年6月毕业于福州大学生物化工专业。主要从事肝癌靶向治疗及其耐药、抗癌药物药理学、肿瘤转移等相关分子研究。主持省部级项目2项、厅级项目2项、校级项目1项，受委托主持卫教联合攻关项目1项，指导博士生获研究生启航基金项目1项。累计在国内外SCI学术刊物上发表论文二十余篇，其中第一作者/共同第一作者发表SCI论文7篇。

科研工作：
1.主持科研项目
[1] 福建省自然科学基金青年创新项目，异构酶Pin1介导上皮-间质转化调控肝细胞癌的侵袭转移研究，2016/04-2019/03，主持
[2] 福建省科技创新联合资金项目，低氧微环境下Pin1对肝癌细胞化疗耐药的作用及机制研究，2016/09-2019/09，主持
2. 发表论文
[1] Jichuang Wang#, Nan Zhang#, Qi Han, Wenxian Lu, Long Wang, Dayun Yang, Min Zheng, Zhenzhen Zhang, Hekun Liu, Tae Ho Lee, Xiao Zhen Zhou, Kun Ping Lu*, Pin1 inhibition reverses the acquired resistance of human hepatocellular carcinoma cells to Regorafenib via the Gli1/Snail/E-cadherin pathway, Cancer Letters, 2019, 444: 82–93
[2] Jichuang Wang#, Xin-Hua Liao#, Min Zheng, Dayun Yang, Xiao Zhen Zhou, Hekun Liu*, Kun Ping Lu*, The roles of the unique prolyl isomerase Pin1 in cancer-related viral and bacterial infections, Current Molecular Medicine, 2016, 16(9): 793-802
[3] Jichuang Wang#, Jianzhong Chen#, Yewei Zhu, Ning Zheng, Jian Liu, Yingying Xiao, Yusheng Lu, Haiyan Dong, Jingjing Xie, Suhong Yu, Jingwei Shao, Lee Jia*, In Vitro and in Vivo Efficacy and Safety Evaluation of Metapristone and Mifepristone as Cancer Metastatic Chemopreventive Agents, Biomedicine and Pharmacotherapy, 2016, 78: 291-300
[4] Jichuang Wang#, Zhou Jiang#, Liping Xiang, Yuanfang Li, Minrui Ou, Xiang Yang, Jingwei Shao*, Yusheng Lu, Lifeng Lin, Jianzhong Chen, Yun Dai, Lee Jia*, Synergism of Ursolic Acid Derivative US597 with 2-deoxy-D-glucose to Preferentially Induce Tumor Cell Death by Dual-targeting of Apoptosis and Glycolysis, Scientific Reports, 2014, 4: 5006
[5] Jichuang Wang#, Jianzhong Chen#, Liyuan Wan, Jingwei Shao*, Yusheng Lu, Yewei Zhu, Minrui Ou, Suhong Yu, Haijun Chen, Lee Jia*, Synthesis, Spectral Characterization, and in Vitro Cellular Activities of Metapristone, a Potential Cancer Metastatic Chemopreventive Agent Derived from Mifepristone (RU486), The AAPS Journal, 2014, 16(2): 289-298
3. 指导学生
已指导2名硕士研究生毕业；指导大学生创新创业项目1项、临床5+3早科研项目1项；指导博士生获得校启航基金项目1项。