徐通达

中心副主任、教授
博士生导师、硕士生导师
国家自然基金委优秀青年基金项目获得者、国家级人才、闽江********
中国植物生理和分子生物学学会常务理事，福建省五四青年奖章
联系地址：
Email: tdxu@sibs.ac.cnor txu002@ucr.edu
实验室网址：
植物营养与激素细胞生物学实验室https://net.fafu.edu.cn/signaling/main.htm

研究方向：

生长素是植物中最重要的激素之一，近百年的研究发现生长素调控了植物几乎所有的生长发育和环境响应过程。生长素作为一个简单的化合物，如何实现如此复杂的生物学功能一直是植物领域的研究热点。
生长素调控植物生长发育具有最典型的浓度效应，不同浓度的生长素在不同条件下会产生完全不同甚至相反的生理反应。前期研究发现，生长素在细胞核内通过其受体TIR1泛素化并降解转录抑制因子Aux/IAA蛋白，从而释放下游转录因子ARF的活性，从经典的转录调控机制参与复杂的生长发育过程。本课题组则发现，生长素通过细胞膜上类受体激酶家族TMK激活下游非转录调控机制。拟通过解析转录调控与非转录调控协同过程，逐步回答生长素浓度效应产生机制及调控机制的关键科学问题。
具体研究方向如下：
1.系统解析植物生长素的非转录调控机制，从TMK家族蛋白入手，深入挖掘生长素信号转导的新机制。
2.解析植物地上部分器官生长素浓度效应产生的分子机制，其中包括向光性反应、顶端弯钩维持、茎尖分生组织的维持等。
3.解析植物地下部分器官生长素浓度效应产生的分子机制，其中包括侧根形成、根分区分化、根尖分生组织维持等。
4.解析生长素局部浓度如何被上游发育信号和环境信号精准调控的分子机制。


代表性文章：
WangQ^#, QinG^#, CaoM, ChenR, HeY, YangL, ZengZ, YuY, GuY, XingW, TaoA, and Xu T^*(2020) A phosphorylation-based switch controls TAA1-mediated auxin biosynthesis in plants. Nature Communications. 11 (1), 1-10
YeB, ShangG, PanY, XuZ, ZhouC, MaoY, BaoN, SunL, XuT, WangJ*.(2020) AP2/ERF Transcription Factors Integrate Age and Wound Signals for Root Regeneration. The Plant Cell 32 (1), 226-241
Huang R^#,Zheng R^#, HeJ^*,ZhouZ,WangJ, Xiong Y,Xu T^*(2019)Non-canonical auxin signaling regulates cell division patterns during lateral root development. Proc Natl Acad Sci USA. 116(42):21285-21290
CaoM^#, Chen R^#, Li P^#, Yu Y, Zheng R, Ge D, Zheng W, Wang X, Gu Y, Gelova Z, Friml J, Zhang H, Liu R, He J, Xu T*(2019) TMK1-mediated auxin signalling regulates differential growth of the apical hook.Nature, 568:240–243
Wang L, Cheng M, Yang Q, Li J, Wang X, Zhou Q, Nagawa S, Xia B, Xu T, Huang R, He J, Li C, Fu Y, Liu Y, Bao J, Wei H, Li H, Tan L, Gu Z, Xia A, Huang X, Yang Z, Deng X (2019) Arabinogalactan protein–rare earth element complexes activate plant endocytosis.Proc Natl Acad Sci USA. 116 (28), 14349-14357
Liang H, Zhang Y, Martinez P, Rasmussen C, Xu T*,Yang Z* (2018) The Microtubule-Associated Protein IQ67 DOMAIN5 Modulates Microtubule Dynamics and Pavement Cell Shape , Plant Physiology,2018.08, 177(4): 1555~1568 * Co-corresponding author
Li H, Luo N, Wang W, Liu Z, Chen J, Zhao L, Tan L, Wang C, Qin Y, Li C, Xu T, Yang Z (2018) The REN4 rheostat dynamically coordinates the apical and lateral domains of Arabidopsis pollen tubes. Nature communications 9 (1), 1-15
Cai W, Li X, Liu Y,Wang Y, Zhou Y, Xu T*, Xiong Y*(2017) COP1 integrates light signals to ROP2 for cell cycle activation. Plant signaling & behavior12 (9), e**
Li X, Cai W, Liu Y, Li Y, Fu L, Liu Z, Xu L, Liu H, Xu T*,and Xiong Y* (2017) Differential TOR activation and cell proliferation in Arabidopsis root and shoot apexes. Proc Natl Acad Sci USA.114:2765-2770.
Li X, Ma D, Lu X, Hu X, Huang R, Liang T, Xu T,Tobin E, Liu H.(2016) Blue Light- and Low Temperature-Regulated COR27 and COR28 Play Roles in the Arabidopsis Circadian Clock , The Plant Cell, 2016.11, 28(11): 2755~2769
J Chen, F Wang, S Zheng, Xu T,Yang Z(2015) Pavement cells: a model system for non-transcriptional auxin signalling and crosstalks. Journal of experimental botany66 (16), 4957-4970
Gu X,Xu T, He Y (2014) A Histone H3 Lysine-27 Methyltransferase Complex Represses Lateral Root Formation in Arabidopsis thaliana. Molecular Plant, 2014.6, 7(6): 977~988
Xu T,Dai N, Chen J, Nagawa S, Cao M, Li H, Zhou Z, Chen X, Rycke R, Rakusova H, Wang W, Jones A, Friml J, Patterson S, Bleecker A, Yang Z. (2014) Cell surface ABP1-TMK auxin sensing complex activates ROP GTPase signaling. Science,343:1025-1028
Li H, Xu T,Lin D, Wen M, Xie M, Duclercq J, Bielach A, Kim J, Reddy GV, Zuo J, Benková E, Friml J, Guo H, Yang Z.. (2013) Cytokinin signaling regulates pavement cell morphogenesis in Arabidopsis. Cell Research,2012.146:1038
Lin D, Nagawa S, Chen J, Cao L, Chen X, Xu T,Li H, Dhonukshe P, Yamamuro C, Friml J, Scheres B, Fu Y and Yang Z. (2012) A ROP GTPase-Dependent Auxin Signaling Pathway Regulates the Subcellular Distribution of PIN2 in Arabidopsis Roots. Current Biology22: 1319-1325.
Xu T.(2011) Rho GTPase Activity Analysis in Plant Cells. Plant Signalling Networks: Methods and Protocols Chapter 10:135-144
Nagawa S*, Xu T*, Lin D, Dhonukshe P, Zhang X, Friml J, Scheres B, Fu Y, Yang Z. (2012) ROP GTPase-dependent actin microfilaments promote PIN1 polarization by localized inhibition of clathrin-dependent endocytosis. PLOS Biology,10:e**. *Co-First Author.
Xu T,Nagawa S, Yang Z. (2011) Uniform auxin triggers the Rho GTPase-dependent formation of interdigitation patterns in pavement cells. Small GTPases0.1:
Xu T,Wen M, Nagawa S, Fu Y, Chen JG, Wu MJ, Perrot-Rechenmann C, Friml J, Jones AM, Yang Z. (2010) Cell Surface- and Rho GTPase-Based Auxin Signaling Controls Cellular Interdigitation in Arabidopsis.Cell,143:99-110
Nagawa S, Xu T, Yang Z. (2010) RHO GTPase in plants: Conservation and invention of regulators and effectors. Small GTPases0.5: 78-88

Fu Y, Xu T,Zhu L, Wen M, Yang Z. (2009) A ROP GTPase signaling pathway controls cortical microtubule ordering and cell expansion in Arabidopsis. Current Biology19: 1827-1832





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