邹修平
在职
**
博士
zouxiuping@cric.cn
**
副研究员
副高
硕导
柑桔抗病基因工程育种与转基因生物安全控制技术研究
博士，副研究员。2000年至今一直从事柑橘分子生物学、抗病基因工程育种和转基因植物生物安全控制新技术的研究，先后参与主研各类项目10余项。现主要从事柑橘黄龙病与寄主互作的分子机制和相关功能基因的研究。2003-2010年，在西南大学生物技术中心攻读硕博士研究生（硕博连读），在这期间先后参与了5项国家自然科学基金项目（项目批准号：**；**；**；**；**）的研究工作。2010年，获得农学博士学位。目前主持一项国家自然科学基金面上项目
zouxiuping
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人员简历

邹修平副研究员/博士/硕导
联系方式：重庆市北碚区歇马镇柑桔村15号 邮编：400712

专长：柑桔抗病基因工程育种与转基因生物安全控制技术研究

个人简介博士，副研究员。2000年至今一直从事柑橘分子生物学、抗病基因工程育种和转基因植物生物安全控制新技术的研究，先后主持国家自然科学基金2项、国家重点研发计划子课题1项、重庆市自然科学基金2项。以通讯作者和第一作者在《Plant Biotechnology Journal》、《The Plant Journal》、《Horticulture Research》、《Frontiers in Plant Science》、《International Journal of Molecular Sciences》等国际国内知名期刊上发表论文30余篇，其中发表SCI收录论文15篇，获得国家发明专利3项，参编国际基因组编辑技术专著《Plant Genome Editing with CRISPR Systems: Methods and Protocols》1部。现主要从事柑橘黄龙病、溃疡病与寄主互作的分子机制和CRISPR/Cas9介导柑橘基因组定点编辑技术的研究。在世界上，首次利用CRISPR/Cas9技术成功定点敲除柑橘感病基因CSLOB1启动子中溃疡病pThA致病因子的识别序列EBE，获得抗柑橘溃疡病突变体育种材料，该研究成果发表在国际权威刊物《Plant Biotechnology Journal》上。
主要研究领域1、利用基因组、转录组、代谢组等现代分子生物技术，解析寄主（柑桔）应答黄龙病和溃疡病病原菌入侵和系统扩散的关键基因及其调控因子，挖掘柑桔抗病和感病关键基因，并通过转基因等技术研究其参与病原菌应答的调控网络和分子机制；
2、结合黄龙病与寄主（柑桔）的互作关系，从病原菌角度大规模筛选和重构柑橘异源新型抗性基因用于柑桔抗黄龙病和溃疡病基因工程育种研究，培育新型抗性材料；
3、利用CRISPR/cas9等最新的基因编辑技术，对柑橘抗/感病基因进行精确修饰和调控，培育抗黄龙病和溃疡病新品种。
代表性成果1、发表的重要论文：Zou Xiuping*, Du Meixia, Liu Yunuo, Wu Liu, Xu Lanzhen, Long Qin, Peng Aihong, He Yongrui, Andrade Maxuel, Chen Shanchun* (2021) CsLOB1 regulates susceptibility to citrus canker through promoting cell proliferation in citrus. The Plant Journal (online). doi: 10.1111/tpj.15217
Long Qin, Du Meixia, Long Junhong, Xie Yu, Zhang Jingyun, Xu Lanzhen, He Yongrui, Li Qiang, Chen Shanchun*, Zou Xiuping* (2021) Transcription factor WRKY22 regulates canker susceptibility in sweet orange (Citrus sinensis Osbeck) by enhancing cell enlargement and CsLOB1 expression. Horticulture Research 8 (1):50
Zou Xiuping*, Zhao Ke, Liu Yunuo, Du Meixia, Zheng Lin, Wang Shuai, Xu Lanzhen, Peng Aihong, He Yongrui, Long Qin, Chen Shanchun* (2021) Overexpression of Salicylic Acid Carboxyl Methyltransferase (CsSAMT1) Enhances Tolerance to Huanglongbing Disease in Wanjincheng Orange (Citrus sinensis (L.) Osbeck). International journal of molecular sciences 22 (6). doi:10.3390/ijms**
Peng Aihong, Zou Xiuping*, He Yongrui, Chen Shanchun, Liu Xiaofeng, Zhang Jingyun, Zhang Qingwen, Xie Zhu, Long Junhong, Zhao Xiaochun* (2021) Overexpressing a NPR1-like gene from Citrus paradisi enhanced Huanglongbing resistance in C. sinensis. Plant Cell Reports 40 (3):529-541
Xie Zhu, Zhao Ke, Long Junhong, Zhen Lin, Zou Xiuping*, Chen Shanchun* (2021) Comparative Analysis of Wanjincheng Orange Leaf And Root Responses to ‘Candidatus Liberibacter asiaticus’ Infection Using Leaf-Disc Grafting. Horticultural Plant Journal (online). doi: 10.1016/j.hpj.2021.01.007
Long Qin, Xie Yu, He Yongrui, Li Qiang, Zou Xiuping*, Chen Shanchun* (2019) Abscisic Acid Promotes Jasmonic Acid Accumulation and Plays a Key Role in Citrus Canker Development. Frontiers in plant science 10:1634
Zou Xiuping*, Long Junhong, Zhao Ke, Peng Aihong, Chen Min, Long Qin, He Yongrui, Chen Shanchun* (2019) Overexpressing GH3.1 and GH3.1L reduces susceptibility to Xanthomonas citri subsp. citri by repressing auxin signaling in citrus (Citrus sinensis Osbeck). PloS one 14 (12):e**
Zou Xiuping*, Bai Xiaojing, Wen Qingli, Xie Zhu, Wu Liu, Peng Aihong, He Yongrui, Xu Lanzhen, Chen Shanchun* (2019) Comparative Analysis of Tolerant and Susceptible Citrus Reveals the Role of Methyl Salicylate Signaling in the Response to Huanglongbing. Journal of Plant Growth Regulation 38 (4):1516-1528
Wang Lijuan, Chen Shanchun, Peng Aihong, Xie Zhu, He Yongrui, Zou Xiuping* (2019) CRISPR/Cas9-mediated editing of CsWRKY22 reduces susceptibility to Xanthomonas citri subsp. citri in Wanjincheng orange (Citrus sinensis (L.) Osbeck). Plant Biotechnology Reports 13 (5):501-510
Peng Aihong, Chen Shanchun, Lei Tiangang, Xu Lanzhen, He Yongrui, Wu Liu, Yao Lixiao, Zou Xiuping* (2017) Engineering canker-resistant plants through CRISPR/Cas9-targeted editing of the susceptibility gene CsLOB1 promoter in citrus. Plant Biotechnology Journal 15 (12):1509–1519
Zou Xiuping*, Jiang Xueyou, Xu Lanzhen, Lei Tiangang, Peng Aihong, He Yongrui, Yao Lixiao, Chen Shanchun* (2017) Transgenic citrus expressing synthesized cecropin B genes in the phloem exhibits decreased susceptibility to Huanglongbing. Plant Molecular Biology 93 (4-5):341-353
Chen Min, He Yongrui, Xu Lanzhen, Peng Aihong, Lei Tiangang, Yao Lixiao, Li Qiang, Zhou Pengfei, Bai Xiaojing, Duan Minjie, Jiang Xueyou, Jia Ruirui, Zou Xiuping*, CHen Shanchun* (2016) Cloning and Expression Analysis of Citrus Genes CsGH3.1 and CsGH3.6 Responding to Xanthomonas axonopodis pv. citri Infection. Horticultural Plant Journal 2 (4):193-202
Peng Aihong, Xu Lanzhen, He Yongrui, Lei Tiangang, Yao Lixiao, Chen Shanchun*, Zou Xiuping* (2015) Efficient production of marker-free transgenic ‘Tarocco’ blood orange ( Citrus sinensis Osbeck) with enhanced resistance to citrus canker using a Cre/ loxP site-recombination system. Plant Cell Tissue & Organ Culture 123 (1):1-13
Zou Xiuping*, Song Erling, Peng Aihong, He Yongrui, Xu Lanzhen, Lei Tiangang, Yao Lixiao, Chen Shanchun* (2014) Activation of three pathogen-inducible promoters in transgenic citrus (Citrus sinensis Osbeck) after Xanthomonas axonopodis pv. citri infection and wounding. Plant Cell Tiss Org 117 (1):85-98
Zou Xiuping*, Peng Aihong, Xu Lanzhen, Liu Xiaofeng, Lei Tiangang, Yao Lixiao, He Yongrui*, Chen Shanchun* (2013) Efficient auto-excision of a selectable marker gene from transgenic citrus by combining the Cre/loxP system and ipt selection. Plant Cell Reports 32 (10):1601-1613
Zou Xiuping, Li Demou, Luo Xiaoying, Luo Keming, Pei Yan* (2008) An improved procedure for Agrobacterium-mediated transformation of trifoliate orange (Poncirus trifoliata L. Raf.) via indirect organogenesis. In Vitro CellDevBiol-Plant 44 (3):169-177
*表示通讯作者
2、著作Jia Hongge, Zou Xiuping, Orbovic Vladimir, Wang Nian* (2019) Genome Editing in Citrus Tree with CRISPR/Cas9. In: Qi Y (ed) Plant Genome Editing with CRISPR Systems: Methods and Protocols. Springer New York, New York, NY, pp 235-241
3、获得的专利陈善春，何永睿，彭爱红，许兰珍，邹修平，彭祝春。一种柑桔的转基因方法（专利号：ZL0.8）
裴炎，邹修平。一种用于有性繁殖植物外源基因生物安全控制的基因自动删除双元系统及其相关植物表达载体（专利号：ZL3.2）
裴炎；邹修平；刘若尘；宋水清；侯磊。杂交作物转基因安全控制的方法和实现该方法的基因删除系统（专利号：ZL2.0）
4、获得的奖项何永睿 ; 陈善春; 彭爱红; 邹修平; 雷天刚; 许兰珍; 姚利晓; 李强; 徐忠强（2018）柑橘分子育种技术体系构建与新种质创制应用。 重庆市人民政府，重庆市科技进步（省部）二等奖