张晓清
学术学位硕士生导师

副教授



xzhang5@cqmu.edu.cn

检验医学院





学科信息


个人简介
张晓清，博士，副教授，硕士生导师。1998.09-2002.07，就读于西南大学化学化工学院化学教育专业，获理学学士学位。2004.09-2009.07，就读于重庆医科大学检验医学院临床检验诊断学专业，硕博连读，获医学博士学位。2007.03-2009.05，在南京大学生命分析化学国家重点实验室交流学习。2015.12-2016.12，在美国肯特州立大学化学与生物学系做访问****。2002.09至今，在重庆医科大学检验医学院从事教学科研工作，主要研究方向：临床疾病诊断的新方法与新技术研究，疾病早期诊断方法研究，疾病诊断的分子标志物，生物活性物质分离分析新技术及临床应用。获得多项国家级、省级科研课题，其中以项目负责人身份获批一项国家自然科学基金项目，两项重庆市市级自然科学基金项目，一项重庆市教委科研项目。发表科研论文19篇，其中以第一作者或通讯作者发表的SCI论文8篇，获批国家发明专利授权1项，参编教材1本，参编专著1部。


科研项目
国家自然科学基金青年科学基金项目：血清胆汁酸谱检测及其在妊娠肝内胆汁淤积症中的作用 [**]
重庆市科学技术委员会基础科学与前沿技术研究项目：血清胆汁酸谱检测新方法研究及临床应用 [cstc2014jcyjA10082]
重庆市教委科技项目科学技术研究项目：血浆吲哚及衍生物的高灵敏检测新方法和临床应用 [KJQN]
重庆市科委市级重点实验室：微流控芯片-电化学检测分析妊娠肝内胆汁淤积症患者血清胆汁酸
中央财政经费特色重点学科基金：微流控芯片分析血清胆汁酸谱用于妊娠肝内胆汁淤积症的诊断和分度










论文情况

主要学术论著：
Gang Tian, Min Ding, Biao Xu, Yifan He, Wenjing Lyu, Mingchao Jin, Xiaoqing Zhang*. A novel electrochemical biosensor for ultrasensitive detection of serum total bile acids based on enzymatic reaction combined with the double oxidation circular amplification strategy. Biosensors & Bioelectronics, 2018, 118: 31-35.
Zhang Xiaoqing, Zhu Mingsong, Xu Biao,Yue Cui, Gang Tian, Zhenghu Shi, Min Ding* Indirect electrochemical detection for total bile acids in human serum. Biosensors & Bioelectronics, 2016, 85: 563-567.
Wenjing Lyu^#, Xiaoqing Zhang^#, Zhong Zhang, Xiao Chen, Ying Zhou, Hong Chen, Haoran Wang, Min Ding*. A simple and sensitive electrochemical method for the determination of capsaicinoids in chilli peppers. Sensors & Actuators: B. Chemical, 2019, 288: 65-70. （共同第一）
Mingchao Jin^#, Xiaoqing Zhang^#, QianNa Zhen, YiFan He, Xiao Chen, Wenjing Lyu, Runchuan Han, Min Ding*. An electrochemical sensor for indole in plasma based on MWCNTs-chitosan modified screen-printed carbon electrode. Biosensors & Bioelectronics, 2017, 98: 392. （共同第一）
Xiaoqing Zhang, Wenping Deng, Yanna Ban, Jieying Gao, Min Ding*. A highly sensitive electrically driven electrochemiluminescent assay for quantification. Analyst, 2013, 138: 5074-5080.
Xiaoqing Zhang, Yun He, Min Ding*. Simultaneous determination of tryptophan and kynurenine in plasma samples of children patients with Kawasaki disease by high-performance liquid chromatography with programmed wavelength ultraviolet detection. Journal of Chromatography B, 2009, 877 : 1678–1682.
ZhengHu Shi^#, XiaoQing Zhang^#, QianNa Zhen, Ming Zuo, Gang Tian, YiFan He, Min Ding*. Direct electrochemical measurement of metanephrines in spot urine samples for the diagnosis of phaeochromocytomas. Scientific Reports, 2017, 7(1).（共同第一）
Xiao Chen^#, Xiaoqing Zhang^#, Biao Xu, Yue Cui, Yifan He, Ting Yang, Yong Shao, Min Ding* . The urinary bile acid profiling analysis of asymptomatic hypercholanemia of pregnancy: A pseudo-targeted metabolomics study. Clinica Chimica Acta, 2019, 497: 67-75. （共同第一）
Yue Cui, Biao Xu, Xiaoqing Zhang, Yifan He, Yong Shao, Min Ding*. Diagnostic and therapeutic profiles of serum bile acids in women with intrahepatic cholestasis of pregnancy-a pseudo-targeted metabolomics study. Clinica Chimica Acta, 2018, 483: 135-141. (被国际著名医学杂志Lancet引用)
Li Ma, Xiaoqing Zhang, Feng Pan, Yue Cui, Ting Yang, Linlin Deng, Yong Shao, Min Ding*. Urinary metabolomic analysis of intrahepatic cholestasis of pregnancy based on high performance liquid chromatography/mass spectrometry. Clinica Chimica Acta, 2017, 471: 292-297.
Gang Tian, Xiaoqing Zhang, Mingsong Zhu, Zhong Zhang, Zhenghu Shi, Min Ding*. Quantification of ethanol in plasma by electrochemical detection with an unmodified screen printed carbon electrode. Scientific Reports, 2016, 6: 23569.
Li Ma, Xiaoqing Zhang, Daxue Zhou, Yue Cui, Linlin Deng, Ting Yang, Yong Shao, Min Ding*. Feasibility of urinary microRNA profiling detection in intrahepatic cholestasis of pregnancy and its potential as a non-invasive biomarker. Scientific Reports, 2016, 6: 31535.
Yuchao Li, Xiaoqing Zhang, Jianbo Chen, Chengya Feng, Yifan He, Yong Shao, Min Ding*. Targeted metabolomics of sulfated bile acids in urine for the diagnosis and grading of intrahepatic cholestasis of pregnancy. Genes & Diseases, 2018, 5: 358-366.
Minglin Ou, Xiaoqing Zhang, Yong Dai, Jieying Gao, Mingsong Zhu, Xiangchun Yang, Yuchao Li, Ting Yang and Min Ding*. Identification of potential microRNA–target pairs associated with osteopetrosis by deep sequencing iTRAQ proteomics and bioinformatics. European Journal of Human Genetics, 2014, 22: 625-632.
Ming Zuo, Qianna Zhen, Xiaoqing Zhang, Wenbi Zou, Xiangchun Yang, Gang Tian, Zhenghu Shi, Qifu Li, Min Ding*. High specificity of spot urinary free metanephrines in diagnosis and prognosis of pheochromocytomas and paragangliomas by HPLC with electrochemical detection. Clinica Chimica Acta, 2018, 478: 82-89.
Jieying Gao, Biao Xu, Xiaoqing Zhang, Yue Cui, Linlin Deng, Zhenghu Shi, Yong Shao, Min Ding*. Association between serum bile acid profiles and gestational diabetes mellitus: A targeted metabolomics study. Clinica Chimica Acta, 2016, 459: 63-72.
Ming Zuo, Jieying Gao, Xiaoqing Zhang, Yue Cui, Zimian Fan, Min Ding*. Capillary electrophoresis with electrochemiluminescence detection for the simultaneous determination of cisatracurium besylate and its degradation products in pharmaceutical preparations. Journal of Separation Science, 2015, 38, 2332-2339.
Li Ma, Jun He, Xiaoqing Zhang, Yue Cui, Jieying Gao, Xiufang Tang, Min Ding*. Determination of total, free, and reduced homocysteine and related aminothiols in uremic patients undergoing hemodialysis by precolumn derivatization HPLC with fluorescence detection.RSC ADVANCES, 2014, 4: 58412-58416.
Jieying Gao, Ting Yang, Mao Ye, Xiaoqing Zhang, Gang Tian, Qianna Zhen, Min Ding*. High-performance liquid chromatography assay with programmed flow elution for cisatracurium in human plasma: Application to pharmacokinetics in infants and children, Journal of Chromatography B, 2014, 955-956: 58-63.


指导研究生情况(近五年)
近五年指导研究生5名，其中1名已于2019年毕业。毕业研究生学位论文获2019年重庆医科大学校优秀毕业论文。

主讲课程
主讲本科生课程《化学分析与仪器分析》

知识产权
获批国家发明专利授权：一种快速检测血浆吲哚的电化学传感器，授权号：CNB，排名：1
获批国家发明专利授权：一种高灵敏的血清总胆汁酸电化学检测方法，授权号：CNB，排名：3
获批国家发明专利授权：血清总胆汁酸检测试剂盒及其使用方法，授权号：CNA，排名：3

著作教材
《生物分析化学》专著，科学出版社，鞠熀先等主编，参编。
《无机及分析化学习题集》教材，人民卫生出版社，潘国石主编，参编。

团队主要成员
丁敏，教授，博导
张晓清，副教授，硕导





研究方向
临床疾病诊断新方法研究/疾病诊断的分子标志物