周辉
学术学位硕士生导师

教授
***


hzhou@cqmu.edu.cn

药学院





学科信息


个人简介
博士，教授，硕士生导师。1998年-2008年在四川大学学习获学士、硕士和博士学位。手性药物是手性技术应用最广泛、效果最显著的领域。目前手性药物占世界上使用药物的50%以上，全球手性药物市场已达数千亿美元，说明了该领域的重要性。我们小组着力发展不对称合成新方法、新技术，为手性药物及中间体的合成提供新方法、新工艺，为新型手性先导化合物的发现提供研究基础。欢迎对本实验室感兴趣的同学来信咨询（hzhou@cqmu.edu.cn）。


科研项目
7) 重庆市自然科学基金面上项目 （cstc2019jcyj-msxmX0034，负责人）
6) 重庆市教委科技项目青年项目（KJQN，负责人）
5) 国家自然科学基金面上项目（**，负责人）
4) 重庆市教委科技项目（KJ**，负责人，已结题）
3）药学院青年师资培养项目（YXY2014QNSZ01，负责人，已结题）
2) 重庆市科委基础与前沿研究一般项目 （cstc2013jcyjA10144, 负责人，已结题）
1) 国家自然科学基金青年项目（**，负责人，已结题）



论文情况
19) Chuanlong Xu, Yuchen Yang, Yue Wu, Feilong He, Huakang He, Ping Deng* and Hui Zhou*, “Development of TsDPEN based imine-containing ligands for the copper-catalysed asymmetric Kinugasa reaction” RSC Adv. 2020, 10, 18107-18114.
18) Jing Zhou, Li-Juan Bai, Guo-Juan Liang, Qi-Gui Xu, Li-Ping Zhou and Hui Zhou*, “Organocatalytic asymmetric cascade 1,6-addition/hemiketalization/retro-Henry reaction of ortho-hydroxyphenyl-substituted p-QMs with α-nitroketones” Org. Biomol. Chem. 2020, 18, 2641-2645.
17) Mouxiong Liu, Dongdong Gui, Ping Deng and Hui Zhou*, “Asymmetric Henry Reaction of 2-Acylpyridine N-Oxides Catalyzed by a Ni-Aminophenol Sulfonamide Complex: An Unexpected Mononuclear Catalyst” Molecules 2019, 24, 1471.
16) Junhao Jiang, Hui Zhou, Qihua Jiang, Lili Sun and Ping Deng*, “Novel Transforming Growth Factor-Beta Receptor 1 Antagonists through a Pharmacophore-Based Virtual Screening Approach” Molecules 2018, 23, 2824.
15) Guanghui Chen, Guojuan Liang, Yiwu Wang, Ping Deng, Hui Zhou*, “A homodinuclear cobalt complex for the catalytic asymmetric Michael reaction of β-ketoesters to nitroolefins” Org. Biomol. Chem. 2018, 16, 3841-3850.
14) Feilong He, Guanghui Chen, Junxia Yang, Guojuan Liang, Ping Deng, Yan Xiong, Hui Zhou*, “Catalytic enantioselective Henry reaction of α-ketoesters, 2-acylpyridines and 2-acylpyridine N-oxides” RSC Adv. 2018, 8, 9414-9422.
13) Jing Zhou, Guojuan Liag, Xiangnan Hu, Liping Zhou, Hui Zhou*, “Facile synthesis of 3-aryl 2,3-dihydrobenzofurans via novel domino 1,6-addition/O-alkylation reactions of para-quinone methides” Tetrahedron, 2018, 74, 1492-1496.
12) Shixiong Zhang, Ping Deng, Jing Zhou, Mouxiong Liu, Guojuan Liang, Yan Xiong, Hui Zhou*, “A novel homobimetallic nickel complex for the asymmetric direct Mannich reaction of imines: a practical method on a multi-gram scale” Chem. Commun. 2017, 53, 12914-12917. (Highlighted by Synfacts, 2018, 14, 285)
11) Youmao Zeng, Ping Deng, Shixiong Zhang, Hong Yan, Guojuan Liang, Yan Xiong, Hui Zhou*, “An Ni-PyBisulidine Complex for the Asymmetric Hydrophosphonylation of Aldehydes” Org. Biomol. Chem. 2016, 14, 9221-9224.
10) Yang Li, Ping Deng, Youmao Zeng, Yan Xiong, Hui Zhou*, “anti-Selective Asymmetric Henry Reaction Catalyzed by a Heterobimetallic Cu-Sm-Aminophenol Sulfonamide Complex” Org. Lett. 2016, 18, 1578-1581.
9) Yajun Liu, Ping Deng, Xiangyang Li, Yan Xiong, Hui Zhou*, “Asymmetric Henry Reaction Catalyzed by a Chiral Dinuclear Nickel Complex” Synlett, 2014, 25, 1735-1738. (Highlighted by Synfacts, 2014, 10, 1045)
8) Tao Wang, Rui Tian, Bin Xiao, Yi Shen, Hui Zhou*, Qingeng Li*, “A Novel Synthesis of Ibutilide Fumarate” Lett. Org. Chem. 2011, 8, 423-426.
7) Hui Zhou, Dahai Chen, Hongwei Gao, Qingeng Li*, “A Mild and Convenient Semi-Synthesis of Docetaxel from 10-Deacetyl Baccatin III” Lett. Org. Chem., 2010, 7, 450-452.
6) Hui Zhou, Dan Peng, Bo Qin, Zongrui Hou, Xiaohua Liu, Xiaoming Feng*, “Highly Enantioselective Aza Henry Reaction of N-tosyl imines Catalyzed by N,N-dixoide-Cu(I) Complex” J. Org. Chem., 2007, 72, 10302-10304.
5) Dan Peng, Hui Zhou, Xiaohua Liu, Liwei Wang, Shikui Chen, Xiaoming Feng* “Enantioselective Cyanoformylation of Aldehydes Catalyzed by a Chiral Quaternary Ammonium Salt and Triethylamine” Synlett, 2007, 15, 2448–2450.
4) Shi-Kui Chen, Dan Peng, Hui Zhou, Li-Wei Wang, Fu-Xue Chen, Xiao-Ming Feng* “Highly Enantioselective Cyanoformylation of Aldehydes Catalyzed by a Mononuclear Salen-Ti(OiPr)₄ Complex Produced In Situ” Eur. J. Org. Chem. 2007, 639–644.
3) Fu-Xue Chen, Hui Zhou, Xiaohua Liu, Bo Qin, Xiaoming Feng,* Guolin Zhang, Yaozhong Jiang, “Enantioselective Cyanosilylation of Ketones by a Catalytic Double Activation Method with an Aluminium Complex and an N-Oxide” Chem. Eur. J. 2004, 10, 4790 – 4797.
2) Fu-Xue Chen, Xiaohua Liu, Bo Qin, Hui Zhou, Xiaoming Feng,* Guolin Zhang, “Highly Efficient Double-Activation Catalysts for the Synthesis of Ketone Cyanohydrins” Synthesis 2004, 14, 2266–2272.
1) Hui Zhou, Fuxue Chen, Bo Qin, Xiaoming Feng*, Guolin Zhang, “Cyanosilylation of Ketones Catalyzed by Quaternary Ammonium Salt and N-oxide” Synlett, 2004, 1077-1079.





主讲课程
药物合成反应
波谱分析
手性药物研究与评价







研究方向
手性技术与手性药物研究、手性药物合成新工艺研究、不对称催化反应研究