穆欣艺
学术学位硕士生导师

副教授



annieamachine@163.com

基础医学院





学科信息


个人简介
研究方向一：卵母细胞第一次减数分裂前期的调控。减数分裂是有性生殖的基础，其中第一次减数分裂前期尤为重要。在这一时期发生的同源重组除了交换染色体片段，还在同源染色体间形成了交叉，保证了后续分裂中期染色体的正确分离。如果第一次减数分裂前期进程受到扰乱，轻则导致非整倍体配子、继而引发流产或先天畸形，重则导致配子凋亡、不育。课题组研究调控小鼠胚胎卵母细胞第一次减数分裂前期进程的分子机理，同时研究不同环境污染物对这一重要过程的影响及机制。
研究方向二：原始卵泡发生的调控。出生前后建立的原始卵泡库储存着女性一生的卵子，因此原始卵泡的发生至关重要。目前研究表明原始卵泡发生主要受到Notch信号和雌激素调控。本课题组研究调控小鼠原始卵泡形成的分子机制，同时研究不同环境污染物对这一重要过程的影响及机理。
研究成果：
共发表SCI论文30余篇，其中以第一作者或共同第一作者身份发表SCI论文10篇（总影响因子50+，单篇论文最高引用数达80余次）
代表性论文：
Mu Xinyi#, Tu Zhihan, Chen Xuemei, Hong Yi, Geng Yanqing, Zhang Yan, Ji Xingduo, Liu Taihang, Wang Yingxiong, He Junlin*, In Utero Exposure to Excessive Estrogen Impairs Homologous Recombination and Oogenesis via Estrogen Receptor 2 in Mice. Frontiers in cell and developmental biology. 2021, doi: 10.3389/fcell.2021.669732.
Yi Hong#, Xinyi Mu#, Xingduo Ji, Xuemei Chen, Yanqing Geng, Yan Zhang, Qiqi Liu, Fangfang Li, Yingxiong Wang, Junlin He*, In-utero exposure to HT-2 toxin affects meiotic progression and early oogenesis in foetal oocytes by increasing oxidative stress. Environmental Pollution. 2021, 279:116917. doi: 10.1016/j.envpol.2021.116917
Tu Zhihan#, Mu Xinyi#, Chen Xuemei, Geng Yanqing, Zhang Yan, Li Qingying, Gao Rufei, Liu Taihang, Wang Yingxiong, He Junlin*, Dibutyl phthalate exposure disrupts the progression of meiotic prophase I by interfering with homologous recombination in fetal mouse oocytes. Environmental Pollution.2019, 252: 388-398. doi: 10.1016/j.envpol.2019.05.107
Tu Zhihan#, Mu Xinyi#, Li Qingying, Gao Rufei, Zhang Yan, Chen Xuemei, Geng Yanqing, Wang Yingxiong, He Junlin*, Autophagy participates in cyst breakdown and primordial folliculogenesis by reducing ROS levels in perinatal mouse ovaries. J Cell Physiol. 2019, 234(5):6125-6135. doi: 10.1002/jcp.27367.
Zhang Yan#, Mu Xinyi#, Gao Rufei, Geng Yanqing, Liu Xueqing, Chen Xuemei, Wang Yuheng, Ding Yubin, Wang Yingxiong, He Junlin*, Foetal-neonatal exposure of Di (2-ethylhexyl) phthalate disrupts ovarian development in mice by inducing autophagy. J Hazard Mater. 2018, 15;358:101-112. doi: 10.1016/j.jhazmat.2018.06.042
Mu Xinyi#, Wen Jia#, Chen Qian, Wang Zhengpin, Wang Yijing, Guo Meng, Yang Yi, Xu JinRui, Wei Zhiqing, Xia Guoliang, Yang Mengye,Wang Chao*, Retinoic acid-induced CYP51 nuclear translocation promotes meiosis prophase I process and is correlated to the expression of REC8 and STAG3 in mice. Biology Open (2018) 7, bio035626. doi: 10.1242/bio.035626
Mu Xinyi# , Liao Xinggui, Chen Xuemei, Li Yanli, Wang Meirong, Shen Cha, Zhang Xue, Wang Yingxiong, Liu Xueqing,H, Junlin*, DEHP exposure impairs mouse oocyte cyst breakdown and primordial follicle assembly through estrogen receptor-dependent and independent mechanisms. J Hazard Mater, 2015, 298：232-240. doi: 10.1016/j.jhazmat.2015.05.052
Mu Xinyi#, Wen Jing, Guo Meng, Wang Jianwei, Li Ge, Wang Zhengpin, Wang Yijing, Teng Zhen, Cui Yan, Xia Guoliang*, Retinoic acid derived from the fetal ovary initiates meiosis in mouse germ cells., Journal of Cellular Physiology, 2013, 228（3）：627-639. doi: 10.1002/jcp.24172
Zhu Jiahong# ,Mu Xinyi#, Zeng Jin, Xu Chunyan, Liu Jun, Zhang Mengsi, Li Chengpeng, Chen Jie, Li Tinyu, Wang Yaping*, Ginsenoside Rg1 prevents cognitive impairment and hippocampus senescence in a rat model of D-galactose-induced aging. PLos One, 2014, 9（6）：e101291-e101291. doi: 10.1371/journal.pone.**
Mu Xinyi#, Zhang Yanyan, Li Jing, Xia Jieyu, Chen Xiongbin, Jing Pengwei, Song Xiaoying, Wang Lu, Wang Yaping *, Angelica Sinensis Polysaccharide prevents hematopoietic stem cells senescence in Dgalactose- induced aging mouse model., Stem cell international. 2017:**. doi: 10.1155/2017/**.


所主持基金项目：
1. 国家自然科学基金青年项目,**,雌二醇抑制胚胎小鼠卵母细胞第一次减数分裂前期的机制,主持
2. 重庆市自然科学基金面上项目，cstc2020jcyjmsxmX0135，妊娠期马兜铃酸暴露抑制胚胎卵母细胞第一次减数分裂前期的机制，主持
3.重庆市基础与前沿一般项目,cstc2016jcyjA0318,雌激素及其类似物抑制胚胎小鼠卵母细胞第一次减数分裂前期的机制,主持
4. 重庆市教委科学技术研究项目，KJ**，环境激素DEHP对小鼠原始卵泡形成的影响及其机制，2015/07-2018/06，主持








研究方向
生殖生物学、生殖毒理