张相军
学术学位硕士生导师

副教授



xiangjunzhang@cqmu.edu.cn

药学院





学科信息


个人简介
学习工作经历：
2011年毕业于山东中医药大学获学士学位，2011-2012先后在济南百诺医药科技开发有限公司及济南康和医药科技有限公司药物制剂部从事仿制药及新药研发工作，2016年毕业于中国人民解放军陆军军医大学（原第三军医大学）药剂学专业获硕士学位，2020年毕业于澳门大学生物医药专业获博士学位。
主要研究方向及科研工作：
1. 纳米药物递送系统及靶向药物；2. 基于特定生理过程的药物递送系统开发；3. 超分子化学在生物医药领域的应用。目前在Materials Today, Nano letters, Theranostics，Journal of Agricultural and Food Chemistry 等领域内主流期刊以第一作者或共同第一作者身份发表学术论文8篇及参与发表论著多篇。
已发表学术创新成果：
1. 基于酵母微囊的新型口服纳米靶向药物递送系统的构建及其在急慢性炎症疾病及肿瘤治疗中的应用；2. 基于主客体作用将超分子主体化合物用于客体毒性化合物及药物毒副作用的解毒；
3. 环境响应性纳米粒的构建及其在防治动脉粥样硬化中的应用。


第一或者共同第一作者论文
1. Xiangjun Zhang, Xiaoqiu Xu, Yidan Chen, Yin Dou, Xing Zhou, Lanlan Li, Chenwen Li, Huijie An, Hui Tao, Houyuan Hu, Xiaohui Li and Jianxiang Zhang, Bioinspired yeast microcapsules loaded with self-assembled nanotherapies for targeted treatment of cardiovascular disease. Materials Today, 2017,20(6): 301-313. (IF:26.416) 材料科学1区
2. Xing Zhou, Xiangjun Zhang (co-first author), Songling Han, Yin Dou, Mengyu Liu, Lin Zhang, Jiawei Guo, Qing Shi, Genghao Gong, Ruibing Wang, Jiang Hu, Xiaohui Li, and Jianxiang Zhang, A yeast microcapsule-mediated targeted delivery of diverse nanoparticles for imaging and therapy via the oral route. Nano Letters, 2017, 17(2),1056-1064. (IF:11.238) 材料科学1区
3. Xiangjun Zhang, Qian Cheng, Lanlan Li, Liqing Shangguan, Chenwen Li, Shengke Li, Feihe Huang, Jianxiang Zhang and Ruibing Wang, Supramolecular therapeutics to treat the side effects induced by a depolarizing neuromuscular blocking agent. Theranostics, 2019, 9(11):3107-3121. (IF:8.579) 医学1区
4. Xiangjun Zhang, Xiaoqiu Xu, Shengke Li, Lanlan Li, Jianxiang Zhang and Ruibing Wang, A Synthetic Receptor as a Specific Antidote for Paraquat Poisoning. Theranostics, 2019, 9(3):633-645. (IF:8.579) 医学1区
5. Hang Yin, Xiangjun Zhang (co-first author), Jianwen Wei, Siyu Lu, David Bardelang and Ruibing Wang, Recent advances in supramolecular antidotes. Theranostics, 2021, 11(3):1513-1526. (IF:8.579) 医学1区
6. Xiangjun Zhang, Qiaoxian Huang, Zhe-ze Zhao, Xiaoqiu Xu, Shengke Li, Hang Yin, Lanlan Li, Jianxiang Zhang and Ruibing Wang. An Eco- and User-Friendly Herbicide, Journal of Agricultural and Food Chemistry. 2019, 67(28), 7783-7792. (IF:4.192) 农林科学1区
7. Xiangjun Zhang, Xiaoqiu Xu, Lian-Hui Wang, Jianxiang Zhang and Ruibing Wang, A systematic evaluation of the biocompatibility of cucurbit [7] uril in mice. Scientific reports, 2018,8:8819. (IF:3.998) 综合性期刊3区
8. Yin Dou, Xiangjun Zhang (co-first author), Xiaoqiu Xu, Xing Zhou, Songling Han, Ruibing Wang, Min Su, Xiaohui Li and Jianxiang Zhang. Multiple noncovalent interactions mediated one-pot therapeutic assemblies for the effective treatment of atherosclerosis. Journal of Materials Chemistry B, 2015,3, 7355-7365. (IF:5.344) 工程技术2区
参与发表论文：
1. Xing Zhou, Kaijian Ling, Mengyu Liu, Xiangjun Zhang, Jun Ding, Yan Dong, Zhiqing Liang, Jianjun Li and Jianxiang Zhang, Targeted Delivery of Cisplatin-Derived Nanoprecursors via a Biomimetic Yeast Microcapsule for Tumor Therapy by the Oral Route. Theranostics, 2019, 9(22):6568-6586. (IF:8.579) 医学1区
2. Chenwen Li, Yang Zhao, Juan Cheng, Jiawei Guo, Qixiong Zhang, Xiangjun Zhang, Jiong Ren, Fengchao Wang, Jun Huang, Houyuan Hu, Ruibing Wang and Jianxiang Zhang, A Proresolving Peptide Nanotherapy for Site‐Specific Treatment of Inflammatory Bowel Disease by Regulating Proinflammatory Microenvironment and Gut Microbiota. Advanced Science, 2019 (IF:15.840) 材料科学1区
3. QiaoXian Huang, Qian Cheng, Xiangjun Zhang, Hang Yin, Lian-Hui Wang and Ruibing Wang, Alleviation of Polycation-Induced Blood Coagulation by the Formation of Polypseudorotaxanes with Macrocyclic Cucurbit[7]uril. ACS Applied Bio Materials, 2018, 1(3):544-548.
4. Chen Sun, Haipeng Zhang, Shengke Li, Xiangjun Zhang, Qian Cheng, Yuanfu Ding, Lian-Hui Wang and Ruibing Wang, Polymeric Nanomedicine with “Lego” Surface Allowing Modular Functionalization and Drug Encapsulation. ACS Applied Materials & Interfaces, 2018,10(30): 25090-25098. (IF:8.758) 材料科学1区
5. QiaoXian Huang, Kit leng Kuok, Xiangjun Zhang, Ludan Yue, Simon M. Y. Lee, Jianxiang Zhang and Ruibing Wang, Inhibition of drug-induced seizure development in both zebrafish and mouse models by a synthetic nanoreceptor. Nanoscale, 2018, 10(22): 10333-10336. (IF:6.895) 材料科学2区
6. Yin Dou, Yue Chen, Xiangjun Zhang, Xiaoqiu Xu, Yidan Chen, Jiawei Guo, Dinglin Zhang, Ruibing Wang, Xiaohui Li and Jianxiang Zhang, Non-proinflammatory and responsive nanoplatforms for targeted treatment of atherosclerosis. Biomaterials, 2017, 143:93-108. (IF:10.317) 工程技术1区
7. Juan Cheng, Shibin Feng, Songling Han, Xiangjun Zhang, Yidan Chen, Xing Zhou, Ruibing Wang, Xiaohui Li, Houyuan Hu, and Jianxiang Zhang, Facile assembly of cost-Effective and locally applicable or injectable nanohemostats for hemorrhage control. ACS Nano, 2016, 10, 9957. (IF:14.588) 材料科学1区
8. Qing Shi, Lin Zhang, Mengyu Liu, Xuelin Zhang, Xiangjun Zhang, Xiaoqiu Xu, Sha Chen, Xiaohui Li and Jianxiang Zhang, Reversion of multidrug resistance by a pH-responsive cyclodextrin-derived nanomedicine in drug resistant cancer cells. Biomaterials, 2015, 67: 169-182. (IF:10.317) 工程技术1区
9. Dinglin Zhang, Yanling Wei, Kai Chen, Xiangjun Zhang, Xiaoqiu Xu, Qing Shi, Songling Han, Xin Chen, Hao Gong, Xiaohui Li and Jianxiang Zhang. Biocompatible Reactive Oxygen Species (ROS) ‐Responsive Nanoparticles as Superior Drug Delivery Vehicles. Advanced Healthcare Materials, 2015, 4(1): 69-76. (IF:7.367) 工程技术2区








研究方向
1. 纳米药物递送系统及靶向药物；2. 基于特定生理过程的药物递送系统开发；3. 超分子化学在生物医药领域的应用。