胡宁
学术学位硕士生导师

副主任医师



@qq.com

第一临床学院





学科信息


个人简介

胡宁（主任医师、副教授、硕士生导师、骨科科研助理和党支部组织委员），同济医科大学本硕连读，重庆医科大学外科学（骨外）博士，美国芝加哥大学博士后、国家援巴巴多斯医疗队优秀队员。荣获重庆市优秀博士论文、中华医学会骨科分会创新与转化三等奖（2018年）、重医附一院学术带头人储备人才（2019年）、重庆市住院医师规范化培训名师（2020年）、重庆市中青年医学高端人才（2020年）等。
美国匹兹堡大学运动医学中心、阿肯色大学关节中心和Mount Carmel New Albany骨科专科医院国际fellow；德国慕尼黑大学Klinikum Landshut和柏林Maria Heimsuchung Caritas-Klinikum Pankow专科医院国际fellow。荣获中国医师协会-美国髋膝关节协会(CAOS-AAHKS)国际奖学金（2016年）、中华医学会运动医疗分会海外医学交流****项目（2020年）。
专注于运动医学和关节外科。临床开展复杂膝关节损伤、膝关节多韧带损伤修复重建、髌骨脱位软组织重建和各类截骨、关节软骨修复、半月板修复、肩关节脱位盂唇和骨性Bankart镜下修复、肩袖撕裂镜下修复、冻结肩松解等复杂肩关节疾病、踝关节运动损伤、关节内骨折微创固定等手术；开展保膝手术、单间室膝关节置换、股骨头坏死保髋治疗，以及髋、膝、肩、肘等微创关节置换和复杂翻修术、膝骨性关节炎分级治疗。
学术任职包括：重庆医学会骨科专委会秘书、中华医学会运动医疗分会下肢运动创伤学组委员、中华医学会运动医疗分会上肢学组青委、中华医学会骨科青年委员会骨科基础学组委员、中国医师协会运动医学医师分会委员、中国医师协会骨科医师分会青委、中国医师协会骨科医师分会关节外科工作委员会青委、中国骨科菁英会关节学组创始会员、ASIA中国分部委员、SICOT中国部基础研究专委会委员、SICOT中国部运动医学专委会委员、中国中西医结合学会骨伤科分会基础专家工作委员会委员、中华预防医学会骨与关节病预防与控制专委会青委、中国研究型医院运动医学专委会委员、中国研究型医院关节外科专委会委员、中国医院研究型关节外科专委会青委、中国医院研究型学会关节外科专委会关节数字化研究学组委员、中国医学救援协会运动伤害分会关节运动伤害学组副主委，中国西部运动医学关节镜协作委员会委员、重庆市医学会骨科专委会关节工作委员会委员、重庆医学会骨科青年委员会委员、重庆市运动医学委员会委员、重庆市健康促进与健康教育学会关节健康专委会常委及副主任委员、重庆市中西医结合学会骨科专委会委员、重庆市中西医结合学会运动医学专委会常委、重庆市医师协会骨科分会关节外科工作委员会委员、重庆市医师协会骨科分会青年委员会委员等。
主持国家自然科学基金面上项目2项，重庆市技术创新与应用发展面上项目1项，重庆市科卫联合医学科研重点项目1项，重庆市科委基金基础和前沿研究项目1项，重庆市卫计委面上项目1项，重医一院博士启动基金1项，重庆医科大学附一院教学改革研究项目2项。以主要参与成员参与6项国家自然科学基金研究，国家863计划项目1项，参与重点产业研发项目1项。主要涉及骨、软骨再生修复、骨组织工程血管化、个性化组织工程支架和多孔钽材料等研发。第一作者、通讯作者SCI论文15篇，共同作者SCI论文32篇。获得国家实用新型专利6项。
参编《现代骨外科学丛书》（第二军医出版社）、《器官系统教材》（人民卫生出版社）、《成人髋关节外科学》（北京大学医学出版社）、《膝关节软骨损伤——从基础研究到手术修复治疗》（人民军医出版社）等。担任《中华创伤外科杂志》英文版、《创伤外科杂志》、《骨科》、《中国生物工程杂志》、《Science Reports》等杂志审稿人。
2017-2018年度经选派参加第二批中国援巴巴多斯医疗队。人民日报（2019年7月24日）以题为“山海缘（新时代之光）”、中共重庆市委主管主办的综合性机关刊物《当代党员》（2019年10期）以题为“援外医生架起友谊之桥”、CCTV4华人世界、巴巴多斯Sunday Sun和The Nations杂志、国家健康报、重庆卫生健康等多次报道优秀事迹。在乌兹别克斯坦国家康复与关节中心开展膝关节置换，获该国电视台新时代新闻 《青年》报道。荣获重医附一院优秀共产党员（2018年）、重庆市事业单位年度考核优秀（2017年、2018年）。
主要科研项目如下：
（1）HIF1a正向调控SLIT3在BMP9促进MSCs成骨分化与血管形成中的作用与机制研究，2021/01-2024/12，国家自然科学基金面上项目（金额:60万）
（2）基于关节镜下膝前交叉韧带IDEAL重建的计算机虚拟混合技术系统研发，2020/10-2022/10，重庆市技术创新与应用发展专项面上项目（金额:20万，项目编号：cstc2020jscx-msxmX0094）
HIF1α与Run2在调控BMP9促进间充质干细胞成骨分化与血管形成双向效应中的作用和分子机制研究，2017/01-2020/12，国家自然科学基金面上项目（金额:57万，项目编号：**）
（3）基于联合损伤机制和解剖结构的 KDMLI 分型及规范化诊治策略的临床研究，2014/09-2022/08，重庆市科卫联合中医药科研项目（金额:20万，项目编号：ZDXM**）
（4）HIF1α协同BMP9修饰骨髓间充质干细胞治疗早期激素性股骨头缺血坏死的机制研究，2014/07-2017/07，重庆市科委面上项目（金额:5万，项目编号：cstc2013jcyjA1003）
（5）BMP诱导干细胞治疗早期激素性股骨头缺血坏死的机制研究，2014/07-2017/07，重庆市卫生局面上项目（金额：2万，项目编号：2013-2-005）
（7）富血小板血浆结合多孔钽棒植入治疗早期股骨头缺血坏死的临床机制研究，2014/07-2017/07，院系级科研启动基金(金额：1万)
（8）PBL教学模式结合标准化病人在卓越班骨科临床教学的探索与应用，2014/07-2017/07，院系级教改课题(金额：1万)

发表文章：
第一作者与通讯作者文章：
1.Serum IL-6 in combination with synovial IL-6 shows excellent diagnostic power to detect hip and knee periprosthetic joint infection.Bone & Joint Research 2020.(已接受)(IF=3.652)
2.In vivo evaluation of porous nano-hydroxyapatite/polyamide-66 cages in a goat cervical spine fusion model. Scientific Reports 2020.(已接受)(IF=4.011)
3.Three-dimensional silk fibroin scaffold enhanced the bone formation and angiogenic differentiation of human amniotic mesenchymal stem cells: a biocompatibility analysis. Acta Biochimica Et Biophysica Sinica 2020(已接受).(IF=2.502)
4.Qin L,Hu N, Li Y, Chen Y, Wang J, Huang W. Evaluation of Synovial Fluid neutrophil CD64 index as a Biomarker of Periprosthetic Joint Infection. The Bone & Joint Journal 2020 April 102B(4):463-469.(IF=4.301)
5.Li Y, Liu Z, Tang Y, Feng W, Zhao C, Liao J, Zhang C, Chen H, Ren Y, Dong S, Liu Y, Hu N, Huang W. Schnurri-3 regulates BMP9-induced osteogenic differentiation and angiogenesis stem cells through Runx2 and VEGF. Cell Death & Disease 2020 Jan 29;11(1):72.(IF=5.959)
6.Qin L, Li F, Gong X, Wang J, Huang W, Hu N. Combined measurement of D-dimer and C-reactive protein levels: highly accurate for diagnosing chronic periprosthetic joint infection. The Journal of Arthroplasty 2020 Jan;35(1):229-234.(IF=3.524)
7.Hu N,Gong X,Yin S,Li Q,Chen H,Li Y, Li F, Qing L, Yang J, Zhu S, Wang J, Li J. Saxagliptin suppresses degradation of type II collagen and aggrecan in primary human chondrocytes: a therapeutic implication in osteoarthritis.Artificial Cells,Nanomedicine,and Biotechnology 2019 Dec;47(1):3239-3245. (IF=4.462)
8.Li F, Qin L, Gong X, Huang Z, Wang T, Liu Z, Sandiford S, Yang J, Zhu S, Liang X, Huang W, Hu N. The Chinese ACL injury population has a higher proportion of small ACL tibial insertion sizes than Western patients. Knee Surg Sports Traumatol Arthrosc. 2020 Mar;28(3):888-896.(IF=3.149)
9.Huang W, Gong X, Sandiford S, He X, Li F, Li Y, Liu Z, Qin L, Yang J, Zhu S, Wang J, Tu X, Ye L, Hu N. Outcome after a new porous tantalum rod implantation for treatment of early-stage femoral head osteonecrosis. Annals of Translational Medicine 2019 Sep;7(18):441.(IF=3.689)
10.Huang W, Gong X, Rahul M, Priyanka S, Wang C, Liang X, Ding G, Hu N. Anterior arthroscopic assisted fixation of posterior cruciate ligament avulsion fractures. Eur J Med Res. 2015 Oct 29;20:88.(IF=1.763)
11.Hu N, Wu XH, Liu R, Yang SH, Huang W, Jiang DM, Wu Q, Xia T, Shao ZW, Ye ZW. Novel application of vacuum sealing drainage with continuous irrigation of potassium permanganate for managing infective wounds of gas gangrene. Journal of Huazhong University of Science and Technology-Medical Sciences 2015, 35(4): 563-568.
12.Hu N, Jiang D, Huang E, Liu X, Li R, Liang X, Kim SH, Chen X, Gao JL, Zhang H, Zhang W, Kong YH, Zhang J, Wang J, Shui W, Luo X, Liu B, Cui J, Rogers MR, Shen J, Zhao C, Wang N, Wu N, Luu HH, Haydon RC, He TC, Huang W. BMP9-regulated angiogenic signaling plays an important role in the osteogenic differentiation of mesenchymal progenitor cells. J Cell Sci. 2013 Jan 15;126(Pt 2):532-41.（IF=6.111）
13.Hu N, Wang C, Liang X, Yin L, Luo X, Liu B, Zhang H, Shui W, Nan G, Wang N, Wu N, Chen X, He Y, Wen S, Deng F, Zhang H, Liao Z, Luu HH, Haydon RC, He TC, Huang W. Inhibition of histone deacetylases potentiates BMP9-induced osteogenic signaling in mouse mesenchymal stem cells. Cell Physiol Biochem. 2013;32(2):486-98.


尚未发表：
Jianye Yang, Steve Sandiford, Sizheng Zhu, Leilei Qin, Jiawei Wang, Feilong Li, Xuan Gong, Xi Liang, Wei Huang, Xiaolin Tu, Ning Hu. The role of thromboelastography in evaluating the changes of coagulation function and guiding anticoagulation during perioperative period of revision total hip arthroplasty on ERAS.


共同作者文章：
1.Chen S, He Y, Wu D, Hu N, Liang X, Jiang D, Huang W, Chen H. Postoperative bone marrow edema lasts no more than 6 months after uncomplicated arthroscopic double-row rotator cuff repair with PEEK anchors.Knee Surg Sports Traumatol Arthrosc. 2020 Feb 14.
2.Wang H, Liu Z, Li Y, Peng Y, Xu W, Hu N, Huang W. Is Remnant Preservation in Anterior Cruciate Ligament Reconstruction Superior to the Standard Technique? A Systematic Review and Meta-Analysis. Biomed Res Int. 2019 Dec 11;2019:**.
3.Chen C, Zhu Z, Hu N, Liang X, Huang W. Leonurine Hydrochloride Suppresses Inflammatory Responses and Ameliorates Cartilage Degradation in Osteoarthritis via NF-κB Signaling Pathway. Inflammation. 2020 Feb;43(1):146-154.
4.Huang X, Wang F, Zhao C, Yang S, Cheng Q, Tang Y, Zhang F, Zhang Y, Luo W, Wang C, Zhou P, Kim S, Zuo G, Hu N, Li R, He TC, Zhang H. Dentinogenesis and Tooth-Alveolar Bone Complex Defects in BMP9/GDF2 Knockout Mice. Stem Cells Dev 2019 May 15;28(10):683-694.
5.Zhao C, Jiang W, Zhou N, Liao J, Yang M, Hu N, Liang X, Xu W, Chen H, Liu W, Shi LL, Oliveira L, Wolf JM, Ho S, Athiviraham A, Tsai HM, He TC, Huang W. Sox9 augments BMP2-induced chondrogenic differentiation by downregulating Smad7 in mesenchymal stem cells (MSCs). Genes Dis. 2017 Dec;4(4):229-239.
6.Li X, Xu W, Hu N, Liang X, Huang W, Jiang D, Chen H. Relationship between acromial morphological variation and subacromial impingement: A three-dimensional analysis. PLoS One 2017 Apr 25;12(4):e**.
7.Xiang BY, Huang W, Zhou GQ, Hu N, Chen H, Chen C. Body mass index and the risk of low bone mass-related fractures in women compared with men: A PRISMA-compliant meta-analysis of prospective cohort studies. Medicine (Baltimore) 2017 Mar;96(12):e5290.
8.Wu XD, Liu MM, Liang X, Hu N, Huang W. Effects of perioperative supplementation with pro-/synbiotics on clinical outcomes in surgical patients: A meta-analysis with trial sequential analysis of randomized controlled trials. Clin Nutr 2018 Apr;37(2):505-515.
9.Zhou N, Li Q, Lin X, Hu N, Liao JY, Lin LB, Zhao C, Hu ZM, Liang X, Xu W, Chen H, Huang W. BMP2 induces chondrogenic differentiation, osteogenic differentiation and endochondral ossification in stem cells. Cell Tissue Res. 2016 Oct;366(1):101-11.
10.Chen H, Huang W, Liang X, Hu N, Xu W, Jiang D. Lateral epicondylar osteotomy for severe varus deformity during total knee arthroplasty. Chin J Traumatol 2015;18(2):102-5.
11.Chen H, Xu W, Hu N, Jiang D, Huang W. Arthroscopic antegrade drilling for unstable juvenile osteochondritis dissecans of the knee: mid-term results. Arch Orthop Trauma Surg 2015 Dec;135(12):1727-32.
12.Zhou N, Hu N, Liao JY, Lin LB, Zhao C, Si WK, Yang Z, Yi SX, Fan TX, Bao W, Liang X, Wei X, Chen H, Chen C, Chen Q, Lin X, Huang W. HIF-1α as a Regulator of BMP2-Induced Chondrogenic Differentiation, Osteogenic Differentiation, and Endochondral Ossification in Stem Cells. Cell Physiol Biochem 2015;36(1):44-60.
13.Mishra R, Shukla P, Huang W, Hu N. Gene mutations in Mycobacterium tuberculosis: multidrug-resistant TB as an emerging global public health crisis. Tuberculosis (Edinb) 2015 Jan;95(1):1-5.
14.Li K, Tie H, Hu N, Chen H, Yin X, Peng C, Wan J, Huang W. Association of two polymorphisms rs** in miRNA-146a and rs** in miRNA-499 with rheumatoid arthritis: a meta-analysis. Hum Immunol 2014 Jul;75(7):602-8.
15.Liao J, Hu N, Zhou N, Lin L, Zhao C, Yi S, Fan T, Bao W, Liang X, Chen H, Xu W, Chen C, Cheng Q, Zeng Y, Si W, Yang Z, Huang W. Sox9 Potentiates BMP2-Induced Chondrogenic Differentiation and Inhibits BMP2-Induced Osteogenic Differentiation. PLoS One. 2014 Feb 13;9(2):e89025.
16.Zhang X, Lin LB, Xu DJ, Chen RF, Tan JX, Liang X, Hu N, Huang W. Wnt3a enhances bone morphogenetic protein 9-induced osteogenic differentiation of C3H10T1/2 cells. Chin Med J (Engl) 2013;126(24):4758-63.
17.Fu C, Xie J, Hu N, Liang X, Chen R, Wang C, Chen C, Xu C, Huang W, Paul Sung KL. Titanium particles up-regulate the activity of matrix metalloproteinase-2 in human synovial cells. Int Orthop 2014 May;38(5):1091-8.
18.Shui W, Yin L, Luo J, Li R, Zhang W, Zhang J, Huang W, Hu N, Liang X, Deng ZL, Hu Z, Shi LL, Luu HH, Haydon RC, He TC, Ho SH. Characterization of chondrocyte scaffold carriers for cell-based gene therapy in articular cartilage repair. J Biomed Mater Res A 2013 Dec;101(12):3542-50.
19.Li WC, Jiang DM, Hu N, Qi XT, Qiao B, Luo XJ. Lipopolysaccharide preconditioning attenuates neuroapoptosis and improves functional recovery through activation of Nrf2 in traumatic spinal cord injury rats. Int J Neurosci 2013 Apr;123(4):240-7.
20.Li RD, Deng ZL, Hu N, Liang X, Liu B, Luo J, Chen L, Yin L, Luo X, Shui W, He TC, Huang W. Biphasic effects of TGFβ1 on BMP9-induced osteogenic differentiation of mesenchymal stem cells. BMB Rep 2012 Sep;45(9):509-14.
21.Yang K, Chen J, Jiang W, Huang E, Cui J, Kim SH, Hu N, Liu H, Zhang W, Li R, Chen X, Kong Y, Zhang J, Wang J, Wang L, Shen J, Luu HH, Haydon RC, Lian X, Yang T, He TC. Conditional immortalization establishes a repertoire of mouse melanocyte progenitors with distinct melanogenic differentiation potential. J Invest Dermatol 2012 Oct;132(10):2479-2483.
22.He BC, Gao JL, Zhang BQ, Luo Q, Shi Q, Kim SH, Huang E, Gao Y, Yang K, Wagner ER, Wang L, Tang N, Luo J, Liu X, Li M, Bi Y, Shen J, Luther G, Hu N, Zhou Q, Luu HH, Haydon RC, Zhao Y, He TC. Tetrandrine inhibits Wnt/β-catenin signaling and suppresses tumor growth of human colorectal cancer. Mol Pharmacol 2011 Feb;79(2):211-9.
23.Zhang L, Li HZ, Gong X, Luo FL, Wang B, Hu N, Wang CD, Zhang Z, Wan JY. Protective effects of Asiaticoside on acute liver injury induced by lipopolysaccharide/D-galactosamine in mice. Phytomedicine 2010 Aug;17(10):811-9.
24.Wagner ER, Luther G, Zhu G, Luo Q, Shi Q, Kim SH, Gao JL, Huang E, Gao Y, Yang K, Wang L, Teven C, Luo X, Liu X, Li M, Hu N, Su Y, Bi Y, He BC, Tang N, Luo J, Chen L, Zuo G, Rames R, Haydon RC, Luu HH, He TC. Defective osteogenic differentiation in the development of osteosarcoma. Sarcoma 2011;2011:325238.
25.Luther G, Rames R, Wagner ER, Zhu G, Luo Q, Bi Y, Kim SH, Gao JL, Huang E, Yang K, Wang L, Liu X, Li M, Hu N, Su Y, Luo X, Chen L, Luo J, Haydon RC, Luu HH, Zhou L, He TC. Molecular basis of differentiation therapy for soft tissue sarcomas. Trends Cancer Res 2010;6:69-90.
26.Gong X, Luo FL, Zhang L, Li HZ, Wu MJ, Li XH, Wang B, Hu N, Wang CD, Yang JQ, Wan JY. Tetrandrine attenuates lipopolysaccharide-induced fulminant hepatic failure in D-galactosamine-sensitized mice. Int Immunopharmacol 2010 Mar;10(3):357-63.
27.Wang CD, Yuan CF, Bu YQ, Wu XM, Wan JY, Zhang L, Hu N, Liu XJ, Zu Y, Liu GL, Song FZ. Fangchinoline inhibits cell proliferation via Akt/GSK-3beta/ cyclin D1 signaling and induces apoptosis in MDA-MB-231 breast cancer cells. Asian Pac J Cancer Prev 2014;15(2):769-73.
28.Luther G, Wagner ER, Zhu G, Kang Q, Luo Q, Lamplot J, Bi Y, Luo X, Luo J, Teven C, Shi Q, Kim SH, Gao JL, Huang E, Yang K, Rames R, Liu X, Li M, Hu N, Liu H, Su Y, Chen L, He BC, Zuo GW, Deng ZL, Reid RR, Luu HH, Haydon RC, He TC. BMP-9 induced osteogenic differentiation of mesenchymal stem cells: molecular mechanism and therapeutic potential. Curr Gene Ther 2011 Jun;11(3):229-40.
29.Teven CM, Liu X, Hu N, Tang N, Kim SH, Huang E, Yang K, Li M, Gao JL, Liu H, Natale RB, Luther G, Luo Q, Wang L, Rames R, Bi Y, Luo J, Luu HH, Haydon RC, Reid RR, He TC. Epigenetic regulation of mesenchymal stem cells: a focus on osteogenic and adipogenic differentiation. Stem Cells Int 2011;2011:201371.
30.Rastegar F, Gao JL, Shenaq D, Luo Q, Shi Q, Kim SH, Jiang W, Wagner ER, Huang E, Gao Y, Shen J, Yang K, He BC, Chen L, Zuo GW, Luo J, Luo X, Bi Y, Liu X, Li M, Hu N, Wang L, Luther G, Luu HH, Haydon RC, He TC. Lysophosphatidic acid acyltransferase β (LPAATβ) promotes the tumor growth of human osteosarcoma. PLoS One 2010 Dec 1;5(12):e14182.
31.Wang J, Zhou Y, Hu N, Wang R. Application of multislice spiral CT for guidance of insertion of thoracic spine pedicle screws: an in vitro study. J Huazhong Univ Sci Technolog Med Sci 2006;26(4):485-8.
32.Fang H, Peng S, Chen A, Li F, Ren K, Hu N. Biocompatibility studies on fibrin glue cultured with bone marrow mesenchymal stem cells in vitro. J Huazhong Univ Sci Technolog Med Sci 2004;24(3):272-4.
其它文章：
1. Xiaoyan Deng,Ning Hu, Lifu Wang, Feilong Li, Geli Liu, Xiangmei Wu,Chengfu Yuan,Zunpeng Liu, Jiachuan Pan, Changdong Wang. Wnt signaling inhibits the growth of primary cilia and activates cyclinD1, snail and VEGFA expression in breast cancer cell line MDA-MB-231. American Journal of Life Sciences 2015;3(3):123-133.
2. Cheng Q, Huang W, Gong X, Wang C, Liang X, Hu N. Minimally invasive percutaneous compression plating versus dynamic hip screw for intertrochanteric fractures: a randomized control trial. Chinese Journal of Traumatology 2014;17(5):249-255.
3. Changdong Wang, Wei Huang, Xuan Gong, Guoliang Ding, Xi Liang, Ning Hu. Decreased Proliferation and Abnormal Differentiation of Human Mesenchymal Stromal Cells in Steroid-Induced Osteonecrosis of Femoral Head. SOJ Biochem 1(1).




科研项目
主要科研项目如下：

（1）HIF1a正向调控SLIT3在BMP9促进MSCs成骨分化与血管形成中的作用与机制研究，2021/01-2024/12，国家自然科学基金面上项目（金额:60万）
（2）基于关节镜下膝前交叉韧带IDEAL重建的计算机虚拟混合技术系统研发，2020/10-2022/10，重庆市技术创新与应用发展专项面上项目（金额:20万，项目编号：cstc2020jscx-msxmX0094）
HIF1α与Run2在调控BMP9促进间充质干细胞成骨分化与血管形成双向效应中的作用和分子机制研究，2017/01-2020/12，国家自然科学基金面上项目（金额:57万，项目编号：**）
（3）基于联合损伤机制和解剖结构的 KDMLI 分型及规范化诊治策略的临床研究，2014/09-2022/08，重庆市科卫联合中医药科研项目（金额:20万，项目编号：ZDXM**）
（4）HIF1α协同BMP9修饰骨髓间充质干细胞治疗早期激素性股骨头缺血坏死的机制研究，2014/07-2017/07，重庆市科委面上项目（金额:5万，项目编号：cstc2013jcyjA1003）
（5）BMP诱导干细胞治疗早期激素性股骨头缺血坏死的机制研究，2014/07-2017/07，重庆市卫生局面上项目（金额：2万，项目编号：2013-2-005）
（7）富血小板血浆结合多孔钽棒植入治疗早期股骨头缺血坏死的临床机制研究，2014/07-2017/07，院系级科研启动基金(金额：1万)
（8）PBL教学模式结合标准化病人在卓越班骨科临床教学的探索与应用，2014/07-2017/07，院系级教改课题(金额：1万)



成果奖励
发表文章：
第一作者与通讯作者文章：
1.Serum IL-6 in combination with synovial IL-6 shows excellent diagnostic power to detect hip and knee periprosthetic joint infection.Bone & Joint Research 2020.(已接受)(IF=3.652)
2.In vivo evaluation of porous nano-hydroxyapatite/polyamide-66 cages in a goat cervical spine fusion model. Scientific Reports 2020.(已接受)(IF=4.011)
3.Three-dimensional silk fibroin scaffold enhanced the bone formation and angiogenic differentiation of human amniotic mesenchymal stem cells: a biocompatibility analysis. Acta Biochimica Et Biophysica Sinica 2020(已接受).(IF=2.502)
4.Qin L,Hu N, Li Y, Chen Y, Wang J, Huang W. Evaluation of Synovial Fluid neutrophil CD64 index as a Biomarker of Periprosthetic Joint Infection. The Bone & Joint Journal 2020 April 102B(4):463-469.(IF=4.301)
5.Li Y, Liu Z, Tang Y, Feng W, Zhao C, Liao J, Zhang C, Chen H, Ren Y, Dong S, Liu Y, Hu N, Huang W. Schnurri-3 regulates BMP9-induced osteogenic differentiation and angiogenesis stem cells through Runx2 and VEGF. Cell Death & Disease 2020 Jan 29;11(1):72.(IF=5.959)
6.Qin L, Li F, Gong X, Wang J, Huang W, Hu N. Combined measurement of D-dimer and C-reactive protein levels: highly accurate for diagnosing chronic periprosthetic joint infection. The Journal of Arthroplasty 2020 Jan;35(1):229-234.(IF=3.524)
7.Hu N,Gong X,Yin S,Li Q,Chen H,Li Y, Li F, Qing L, Yang J, Zhu S, Wang J, Li J. Saxagliptin suppresses degradation of type II collagen and aggrecan in primary human chondrocytes: a therapeutic implication in osteoarthritis.Artificial Cells,Nanomedicine,and Biotechnology 2019 Dec;47(1):3239-3245. (IF=4.462)
8.Li F, Qin L, Gong X, Huang Z, Wang T, Liu Z, Sandiford S, Yang J, Zhu S, Liang X, Huang W, Hu N. The Chinese ACL injury population has a higher proportion of small ACL tibial insertion sizes than Western patients. Knee Surg Sports Traumatol Arthrosc. 2020 Mar;28(3):888-896.(IF=3.149)
9.Huang W, Gong X, Sandiford S, He X, Li F, Li Y, Liu Z, Qin L, Yang J, Zhu S, Wang J, Tu X, Ye L, Hu N. Outcome after a new porous tantalum rod implantation for treatment of early-stage femoral head osteonecrosis. Annals of Translational Medicine 2019 Sep;7(18):441.(IF=3.689)
10.Huang W, Gong X, Rahul M, Priyanka S, Wang C, Liang X, Ding G, Hu N. Anterior arthroscopic assisted fixation of posterior cruciate ligament avulsion fractures. Eur J Med Res. 2015 Oct 29;20:88.(IF=1.763)
11.Hu N, Wu XH, Liu R, Yang SH, Huang W, Jiang DM, Wu Q, Xia T, Shao ZW, Ye ZW. Novel application of vacuum sealing drainage with continuous irrigation of potassium permanganate for managing infective wounds of gas gangrene. Journal of Huazhong University of Science and Technology-Medical Sciences 2015, 35(4): 563-568.
12.Hu N, Jiang D, Huang E, Liu X, Li R, Liang X, Kim SH, Chen X, Gao JL, Zhang H, Zhang W, Kong YH, Zhang J, Wang J, Shui W, Luo X, Liu B, Cui J, Rogers MR, Shen J, Zhao C, Wang N, Wu N, Luu HH, Haydon RC, He TC, Huang W. BMP9-regulated angiogenic signaling plays an important role in the osteogenic differentiation of mesenchymal progenitor cells. J Cell Sci. 2013 Jan 15;126(Pt 2):532-41.（IF=6.111）
13.Hu N, Wang C, Liang X, Yin L, Luo X, Liu B, Zhang H, Shui W, Nan G, Wang N, Wu N, Chen X, He Y, Wen S, Deng F, Zhang H, Liao Z, Luu HH, Haydon RC, He TC, Huang W. Inhibition of histone deacetylases potentiates BMP9-induced osteogenic signaling in mouse mesenchymal stem cells. Cell Physiol Biochem. 2013;32(2):486-98.


尚未发表：
Jianye Yang, Steve Sandiford, Sizheng Zhu, Leilei Qin, Jiawei Wang, Feilong Li, Xuan Gong, Xi Liang, Wei Huang, Xiaolin Tu, Ning Hu. The role of thromboelastography in evaluating the changes of coagulation function and guiding anticoagulation during perioperative period of revision total hip arthroplasty on ERAS.


共同作者文章：
1.Chen S, He Y, Wu D, Hu N, Liang X, Jiang D, Huang W, Chen H. Postoperative bone marrow edema lasts no more than 6 months after uncomplicated arthroscopic double-row rotator cuff repair with PEEK anchors.Knee Surg Sports Traumatol Arthrosc. 2020 Feb 14.
2.Wang H, Liu Z, Li Y, Peng Y, Xu W, Hu N, Huang W. Is Remnant Preservation in Anterior Cruciate Ligament Reconstruction Superior to the Standard Technique? A Systematic Review and Meta-Analysis. Biomed Res Int. 2019 Dec 11;2019:**.
3.Chen C, Zhu Z, Hu N, Liang X, Huang W. Leonurine Hydrochloride Suppresses Inflammatory Responses and Ameliorates Cartilage Degradation in Osteoarthritis via NF-κB Signaling Pathway. Inflammation. 2020 Feb;43(1):146-154.
4.Huang X, Wang F, Zhao C, Yang S, Cheng Q, Tang Y, Zhang F, Zhang Y, Luo W, Wang C, Zhou P, Kim S, Zuo G, Hu N, Li R, He TC, Zhang H. Dentinogenesis and Tooth-Alveolar Bone Complex Defects in BMP9/GDF2 Knockout Mice. Stem Cells Dev 2019 May 15;28(10):683-694.
5.Zhao C, Jiang W, Zhou N, Liao J, Yang M, Hu N, Liang X, Xu W, Chen H, Liu W, Shi LL, Oliveira L, Wolf JM, Ho S, Athiviraham A, Tsai HM, He TC, Huang W. Sox9 augments BMP2-induced chondrogenic differentiation by downregulating Smad7 in mesenchymal stem cells (MSCs). Genes Dis. 2017 Dec;4(4):229-239.
6.Li X, Xu W, Hu N, Liang X, Huang W, Jiang D, Chen H. Relationship between acromial morphological variation and subacromial impingement: A three-dimensional analysis. PLoS One 2017 Apr 25;12(4):e**.
7.Xiang BY, Huang W, Zhou GQ, Hu N, Chen H, Chen C. Body mass index and the risk of low bone mass-related fractures in women compared with men: A PRISMA-compliant meta-analysis of prospective cohort studies. Medicine (Baltimore) 2017 Mar;96(12):e5290.
8.Wu XD, Liu MM, Liang X, Hu N, Huang W. Effects of perioperative supplementation with pro-/synbiotics on clinical outcomes in surgical patients: A meta-analysis with trial sequential analysis of randomized controlled trials. Clin Nutr 2018 Apr;37(2):505-515.
9.Zhou N, Li Q, Lin X, Hu N, Liao JY, Lin LB, Zhao C, Hu ZM, Liang X, Xu W, Chen H, Huang W. BMP2 induces chondrogenic differentiation, osteogenic differentiation and endochondral ossification in stem cells. Cell Tissue Res. 2016 Oct;366(1):101-11.
10.Chen H, Huang W, Liang X, Hu N, Xu W, Jiang D. Lateral epicondylar osteotomy for severe varus deformity during total knee arthroplasty. Chin J Traumatol 2015;18(2):102-5.
11.Chen H, Xu W, Hu N, Jiang D, Huang W. Arthroscopic antegrade drilling for unstable juvenile osteochondritis dissecans of the knee: mid-term results. Arch Orthop Trauma Surg 2015 Dec;135(12):1727-32.
12.Zhou N, Hu N, Liao JY, Lin LB, Zhao C, Si WK, Yang Z, Yi SX, Fan TX, Bao W, Liang X, Wei X, Chen H, Chen C, Chen Q, Lin X, Huang W. HIF-1α as a Regulator of BMP2-Induced Chondrogenic Differentiation, Osteogenic Differentiation, and Endochondral Ossification in Stem Cells. Cell Physiol Biochem 2015;36(1):44-60.
13.Mishra R, Shukla P, Huang W, Hu N. Gene mutations in Mycobacterium tuberculosis: multidrug-resistant TB as an emerging global public health crisis. Tuberculosis (Edinb) 2015 Jan;95(1):1-5.
14.Li K, Tie H, Hu N, Chen H, Yin X, Peng C, Wan J, Huang W. Association of two polymorphisms rs** in miRNA-146a and rs** in miRNA-499 with rheumatoid arthritis: a meta-analysis. Hum Immunol 2014 Jul;75(7):602-8.
15.Liao J, Hu N, Zhou N, Lin L, Zhao C, Yi S, Fan T, Bao W, Liang X, Chen H, Xu W, Chen C, Cheng Q, Zeng Y, Si W, Yang Z, Huang W. Sox9 Potentiates BMP2-Induced Chondrogenic Differentiation and Inhibits BMP2-Induced Osteogenic Differentiation. PLoS One. 2014 Feb 13;9(2):e89025.
16.Zhang X, Lin LB, Xu DJ, Chen RF, Tan JX, Liang X, Hu N, Huang W. Wnt3a enhances bone morphogenetic protein 9-induced osteogenic differentiation of C3H10T1/2 cells. Chin Med J (Engl) 2013;126(24):4758-63.
17.Fu C, Xie J, Hu N, Liang X, Chen R, Wang C, Chen C, Xu C, Huang W, Paul Sung KL. Titanium particles up-regulate the activity of matrix metalloproteinase-2 in human synovial cells. Int Orthop 2014 May;38(5):1091-8.
18.Shui W, Yin L, Luo J, Li R, Zhang W, Zhang J, Huang W, Hu N, Liang X, Deng ZL, Hu Z, Shi LL, Luu HH, Haydon RC, He TC, Ho SH. Characterization of chondrocyte scaffold carriers for cell-based gene therapy in articular cartilage repair. J Biomed Mater Res A 2013 Dec;101(12):3542-50.
19.Li WC, Jiang DM, Hu N, Qi XT, Qiao B, Luo XJ. Lipopolysaccharide preconditioning attenuates neuroapoptosis and improves functional recovery through activation of Nrf2 in traumatic spinal cord injury rats. Int J Neurosci 2013 Apr;123(4):240-7.
20.Li RD, Deng ZL, Hu N, Liang X, Liu B, Luo J, Chen L, Yin L, Luo X, Shui W, He TC, Huang W. Biphasic effects of TGFβ1 on BMP9-induced osteogenic differentiation of mesenchymal stem cells. BMB Rep 2012 Sep;45(9):509-14.
21.Yang K, Chen J, Jiang W, Huang E, Cui J, Kim SH, Hu N, Liu H, Zhang W, Li R, Chen X, Kong Y, Zhang J, Wang J, Wang L, Shen J, Luu HH, Haydon RC, Lian X, Yang T, He TC. Conditional immortalization establishes a repertoire of mouse melanocyte progenitors with distinct melanogenic differentiation potential. J Invest Dermatol 2012 Oct;132(10):2479-2483.
22.He BC, Gao JL, Zhang BQ, Luo Q, Shi Q, Kim SH, Huang E, Gao Y, Yang K, Wagner ER, Wang L, Tang N, Luo J, Liu X, Li M, Bi Y, Shen J, Luther G, Hu N, Zhou Q, Luu HH, Haydon RC, Zhao Y, He TC. Tetrandrine inhibits Wnt/β-catenin signaling and suppresses tumor growth of human colorectal cancer. Mol Pharmacol 2011 Feb;79(2):211-9.
23.Zhang L, Li HZ, Gong X, Luo FL, Wang B, Hu N, Wang CD, Zhang Z, Wan JY. Protective effects of Asiaticoside on acute liver injury induced by lipopolysaccharide/D-galactosamine in mice. Phytomedicine 2010 Aug;17(10):811-9.
24.Wagner ER, Luther G, Zhu G, Luo Q, Shi Q, Kim SH, Gao JL, Huang E, Gao Y, Yang K, Wang L, Teven C, Luo X, Liu X, Li M, Hu N, Su Y, Bi Y, He BC, Tang N, Luo J, Chen L, Zuo G, Rames R, Haydon RC, Luu HH, He TC. Defective osteogenic differentiation in the development of osteosarcoma. Sarcoma 2011;2011:325238.
25.Luther G, Rames R, Wagner ER, Zhu G, Luo Q, Bi Y, Kim SH, Gao JL, Huang E, Yang K, Wang L, Liu X, Li M, Hu N, Su Y, Luo X, Chen L, Luo J, Haydon RC, Luu HH, Zhou L, He TC. Molecular basis of differentiation therapy for soft tissue sarcomas. Trends Cancer Res 2010;6:69-90.
26.Gong X, Luo FL, Zhang L, Li HZ, Wu MJ, Li XH, Wang B, Hu N, Wang CD, Yang JQ, Wan JY. Tetrandrine attenuates lipopolysaccharide-induced fulminant hepatic failure in D-galactosamine-sensitized mice. Int Immunopharmacol 2010 Mar;10(3):357-63.
27.Wang CD, Yuan CF, Bu YQ, Wu XM, Wan JY, Zhang L, Hu N, Liu XJ, Zu Y, Liu GL, Song FZ. Fangchinoline inhibits cell proliferation via Akt/GSK-3beta/ cyclin D1 signaling and induces apoptosis in MDA-MB-231 breast cancer cells. Asian Pac J Cancer Prev 2014;15(2):769-73.
28.Luther G, Wagner ER, Zhu G, Kang Q, Luo Q, Lamplot J, Bi Y, Luo X, Luo J, Teven C, Shi Q, Kim SH, Gao JL, Huang E, Yang K, Rames R, Liu X, Li M, Hu N, Liu H, Su Y, Chen L, He BC, Zuo GW, Deng ZL, Reid RR, Luu HH, Haydon RC, He TC. BMP-9 induced osteogenic differentiation of mesenchymal stem cells: molecular mechanism and therapeutic potential. Curr Gene Ther 2011 Jun;11(3):229-40.
29.Teven CM, Liu X, Hu N, Tang N, Kim SH, Huang E, Yang K, Li M, Gao JL, Liu H, Natale RB, Luther G, Luo Q, Wang L, Rames R, Bi Y, Luo J, Luu HH, Haydon RC, Reid RR, He TC. Epigenetic regulation of mesenchymal stem cells: a focus on osteogenic and adipogenic differentiation. Stem Cells Int 2011;2011:201371.
30.Rastegar F, Gao JL, Shenaq D, Luo Q, Shi Q, Kim SH, Jiang W, Wagner ER, Huang E, Gao Y, Shen J, Yang K, He BC, Chen L, Zuo GW, Luo J, Luo X, Bi Y, Liu X, Li M, Hu N, Wang L, Luther G, Luu HH, Haydon RC, He TC. Lysophosphatidic acid acyltransferase β (LPAATβ) promotes the tumor growth of human osteosarcoma. PLoS One 2010 Dec 1;5(12):e14182.
31.Wang J, Zhou Y, Hu N, Wang R. Application of multislice spiral CT for guidance of insertion of thoracic spine pedicle screws: an in vitro study. J Huazhong Univ Sci Technolog Med Sci 2006;26(4):485-8.
32.Fang H, Peng S, Chen A, Li F, Ren K, Hu N. Biocompatibility studies on fibrin glue cultured with bone marrow mesenchymal stem cells in vitro. J Huazhong Univ Sci Technolog Med Sci 2004;24(3):272-4.
其它文章：
1. Xiaoyan Deng,Ning Hu, Lifu Wang, Feilong Li, Geli Liu, Xiangmei Wu,Chengfu Yuan,Zunpeng Liu, Jiachuan Pan, Changdong Wang. Wnt signaling inhibits the growth of primary cilia and activates cyclinD1, snail and VEGFA expression in breast cancer cell line MDA-MB-231. American Journal of Life Sciences 2015;3(3):123-133.
2. Cheng Q, Huang W, Gong X, Wang C, Liang X, Hu N. Minimally invasive percutaneous compression plating versus dynamic hip screw for intertrochanteric fractures: a randomized control trial. Chinese Journal of Traumatology 2014;17(5):249-255.
3. Changdong Wang, Wei Huang, Xuan Gong, Guoliang Ding, Xi Liang, Ning Hu. Decreased Proliferation and Abnormal Differentiation of Human Mesenchymal Stromal Cells in Steroid-Induced Osteonecrosis of Femoral Head. SOJ Biochem 1(1).


奖励：
2017年援巴巴多斯
讲课比赛
2018COA骨科创新与转化三等奖







研究方向
尚未录入;