凌智瑜
学术学位硕士生导师

副教授



lingzhiyu@cqmu.edu.cn

第二临床学院





学科信息


个人简介
医学博士，主任医师，副教授。硕士研究生导师。重庆医科大学附属第二医院心内科副主任。第三批重庆市学科与学术带头人后备人选，中华医学会心血管病分会青年委员，中国医师协会心血管分会青年委员会委员，中华医学会心电生理和起搏分会青年委员。重庆市医学会心脏起搏与电生理分会委员兼青年委员会副主任委员。2013年3月~2014年3月在美国霍普金斯大学医院从事博士后研究（Postdoctoral Research Fellowship）1年，师从2013~2014年度美国心律协会（Heart Rhythm Society）主席Hugh Calkins教授。《临床超声医学杂志》编委，国家自然科学基金一审专家，为Annals of Internal Medicine，Catheterization And Cardiovascular Interventions，Clinical and Experimental Hypertension杂志的特约审稿专家。主持国家自然科学基金2项，重庆市科委及卫计委等其他项目多项。作为第三完成人获得教育部科技进步二等奖一项。近年来以第1作者在ACS Appl Mater Interfaces；J Am Coll Cardiol. 2013; 62(23):2215-6; Circulation: Arrhythm & Electrophysiol.2014; 7(2):237-43; Heart Rhythm 2015; 12:857–864; Int J Cardiol. 2014; 173(2):345-6.; Curr Treat Options Cardiovasc Med. 2014; 16(4):297; Ultrasound Med Biol. 2013; 39(11):2001-10.等国际著名SCI期刊发表论文7篇, 以共同第一作者及其他排名作者SCI期刊发表论文10余篇。




成果奖励

1.肾素血管紧张素系统抑制剂防治心房颤动的临床与基础研究,教育部高等学校科技进步奖，二等奖,第三完成人


2.心房颤动的发病机制与临床防治研究,重庆市卫生局医学科学技术成果奖，一等奖，第三完成人







科研项目
项目名称
负责人
研究类型

CNA35胶原靶向氟碳纳米粒检测心肌纤维化的超声分子显像研究
凌智瑜
国家自然科学基金面上项目

超声辐照微泡诱导心肌微环境改变联合骨髓干细胞移植促心肌血管新生研究
凌智瑜
国家自然科学基金青年项目

经导管消融肾动脉去交感神经对心力衰竭犬心肌重塑的影响及其机制
凌智瑜
重庆市卫生局重点项目

经导管肾动脉消融去交感神经改善心力衰竭犬心肌重构及其机制研究
凌智瑜
重庆市科委面上项目

肺静脉前庭及不同部位心房肌组织的量化消融研究
凌智瑜
重庆市科卫联合重点项目




著作教材
姓名
书名
参编
情况
出版社
ISBN编号

凌智瑜
心电生理知识入门
参编
科学技术文献出版社
65

凌智瑜
超声分子影像学
参编
科学出版社
32

凌智瑜
心电图诊断掌中宝（彩图版）
参编
化学工业出版社
74




知识产权
1) 发明专利：20**一种电生理导管
2) 发明专利：53超声微泡造影剂定位控释方法
3) 发明专利：31超声微泡靶向定位控释药物/基因装置及靶向转移 的方法



论文情况
1.Cai L, Yin Y, Ling Z, Su L, Liu Z, Wu J, Du H, Lan X, Fan J, Chen W, Xu Y, Zhou P, Zhu J, Zrenner B. Predictors of late recurrence of atrial fibrillation after catheter ablation [J]. Int J Cardiol.(IF:6.175), 2013, 164(1): 82-87. doi:10.1016/j.ijcard.2011.06.094
2.Chen S, Acou WJ, Kiuchi MG, Meyer C, Sommer P, Martinek M, Schratter A, Andrea BR, Ling Z, Liu S, Yin Y, Hindricks G, Purerfellner H, Krucoff MW, Schmidt B, Chun KRJ. Association of Preoperative Renin-Angiotensin System Inhibitors With Prevention of Postoperative Atrial Fibrillation and Adverse Events: A Systematic Review and Meta-analysis [J]. JAMA Netw Open, 2019, 2(5): e194934. doi:10.1001/jamanetworkopen.2019.4934
3.Chen S, Dong Y, Kiuchi MG, Wang J, Li R, Ling Z, Zhou T, Wang Z, Martinek M, Purerfellner H, Liu S, Krucoff MW. Coronary Artery Complication in Kawasaki Disease and the Importance of Early Intervention : A Systematic Review and Meta-analysis [J]. JAMA Pediatr, 2016(IF: 12.004), 170(12): 1156-1163. doi:10.1001/jamapediatrics.2016.2055
4.Chen S, Ling Z, Kiuchi MG, Yin Y, Krucoff MW. The efficacy and safety of cardiac resynchronization therapy combined with implantable cardioverter defibrillator for heart failure: a meta-analysis of 5674 patients [J]. Europace.(IF: 6.100), 2013, 15(7): 992-1001. doi:10.1093/europace/eus419
5.Chen S, Ling Z, Yin Y, Li C, Zhang B, Zrenner B, Krucoff MW. The comparison of epicardial focused ultrasound circumferential pulmonary vein ablation and BOX ablation--results from experimental acute atrial fibrillation [J]. J Interv Card Electrophysiol.(IF: 1.534), 2012, 34(2): 153-159. doi:10.1007/s10840-011-9659-9
6.Chen S, Purerfellner H, Meyer C, Acou WJ, Schratter A, Ling Z, Liu S, Yin Y, Martinek M, Kiuchi MG, Schmidt B, Chun KRJ. Rhythm control for patients with atrial fibrillation complicated with heart failure in the contemporary era of catheter ablation: a stratified pooled analysis of randomized data [J]. Eur Heart J.(IF: 23.239), 2019. doi:10.1093/eurheartj/ehz443
7.Chen S, Yin Y, Lan X, Liu Z, Ling Z, Su L, Kiuchi MG, Li X, Zhong B, Krucoff MW. Paced QRS duration as a predictor for clinical heart failure events during right ventricular apical pacing in patients with idiopathic complete atrioventricular block: results from an observational cohort study (PREDICT-HF) [J]. Eur J Heart Fail.(IF: 13.965), 2013, 15(3): 352-359. doi:10.1093/eurjhf/hfs199
8.Chen S, Yin Y, Ling Z, Krucoff MW. Short and long term effect of adjunctive intra-aortic balloon pump use for patients undergoing high risk reperfusion therapy: a meta-analysis of 10 international randomised trials [J]. Heart.(IF:6.023), 2014, 100(4): 303-310. doi:10.1136/heartjnl-2013-304198
9.Chen W, Du H, Lu J, Ling Z, Long Y, Xu Y, Xiao P, Gyawali L, Woo K, Yin Y, Zrenner B. Renal Artery Vasodilation May Be An Indicator of Successful Sympathetic Nerve Damage During Renal Denervation Procedure [J]. Sci Rep.(IF:4.259), 2016, 637218. doi:10.1038/srep37218
10.Chen W,Ling Z, Du H, Song W, Xu Y, Liu Z, Su L, Xiao P, Yuan Y, Lu J, Zhang J, Li Z, Shao J, Zhong B, Zhou B, Woo K, Yin Y. The effect of two different renal denervation strategies on blood pressure in resistant hypertension: Comparison of full-length versus proximal renal artery ablation [J]. Catheter Cardiovasc Interv.(IF: 2.602), 2016, 88(5): 786-795. doi:10.1002/ccd.26594
11.Chen W, Ling Z, Xu Y, Liu Z, Su L, Du H, Xiao P, Lan X, Shan Q, Yin Y. Preliminary effects of renal denervation with saline irrigated catheter on cardiac systolic function in patients with heart failure: A Prospective, Randomized, Controlled, Pilot Study [J]. Catheter Cardiovasc Interv.(IF: 2.602), 2017, 89(4): E153-e161. doi:10.1002/ccd.26475
12.Chen W, Liu H, Ling Z, Xu Y, Fan J, Du H, Xiao P, Su L, Liu Z, Lan X, Zrenner B, Yin Y. Efficacy of Short-Term Antiarrhythmic Drugs Use after Catheter Ablation of Atrial Fibrillation-A Systematic Review with Meta-Analyses and Trial Sequential Analyses of Randomized Controlled Trials [J]. PLoS One.(IF: 2.806), 2016, 11(5): e**. doi:10.1371/journal.pone.**
13.Chen YL, Fan J, Cao L, Han TL, Zeng M, Xu Y, Ling Z, Yin Y. Unique mechanistic insights into the beneficial effects of angiotensin-(1-7) on the prevention of cardiac fibrosis: A metabolomic analysis of primary cardiac fibroblasts [J]. Exp Cell Res.(IF: 3.329), 2019, 378(2): 158-170. doi:10.1016/j.yexcr.2019.03.006
14.Du H, Fan J, Ling Z, Woo K, Su L, Chen S, Liu Z, Lan X, Zhou B, Xu Y, Chen W, Xiao P, Yin Y. Effect of nifedipine versus telmisartan on prevention of atrial fibrillation recurrence in hypertensive patients [J]. Hypertension.(IF:7.632), 2013, 61(4): 786-792. doi:10.1161/hypertensionaha.111.202309
15.Fan J, Cao H, Su L, Ling Z, Liu Z, Lan X, Xu Y, Chen W, Yin Y. NT-proBNP, but not ANP and C-reactive protein, is predictive of paroxysmal atrial fibrillation in patients undergoing pulmonary vein isolation [J]. J Interv Card Electrophysiol.(IF:1.534), 2012, 33(1): 93-100. doi:10.1007/s10840-011-9606-9
16.Fan J, Du H, Yin Y, Ling Z, Wu J, Xiao P, Zrenner B. Efficacy and safety of zotarolimus-eluting stents compared with sirolimus-eluting stents in patients undergoing percutaneous coronary interventions--a meta-analysis of randomized controlled trials [J]. Int J Cardiol.(IF:6.175), 2013, 167(5): 2126-2133. doi:10.1016/j.ijcard.2012.05.105
17.Fan J, Zou L, Cui K, Woo K, Du H, Chen S, Ling Z, Zhang Q, Zhang B, Lan X, Su L, Zrenner B, Yin Y. Atrial overexpression of angiotensin-converting enzyme 2 improves the canine rapid atrial pacing-induced structural and electrical remodeling. Fan, ACE2 improves atrial substrate remodeling [J]. Basic Res Cardiol.(IF:6.470), 2015, 110(4): 45. doi:10.1007/s00395-015-0499-0
18.Ling Z, Hari A, Tandri H. VT ablation: New Developments and Approaches [J]. Curr Treat Options Cardiovasc Med, 2014, 16(4): 297. doi:10.1007/s11936-014-0297-2
19.Ling Z, Jia F, Xu Y, Su L, Liu Z, Du H, Yang X, Lan X, Xiao P, Chen W, Fan J, Luo S, Yin Y, Nazarian S. Dual antiplatelet therapy versus warfarin anticoagulation in patients undergoing catheter ablation of atrial fibrillation [J]. Int J Cardiol.(IF:6.175), 2014, 173(2): 345-346. doi:10.1016/j.ijcard.2014.03.027
20.Ling Z,Liu Z, Su L, Zipunnikov V, Wu J, Du H, Woo K, Chen S, Zhong B, Lan X, Fan J, Xu Y, Chen W, Yin Y, Nazarian S, Zrenner B. Radiofrequency ablation versus antiarrhythmic medication for treatment of ventricular premature beats from the right ventricular outflow tract: prospective randomized study [J]. Circ Arrhythm Electrophysiol(IF: 4.968), 2014, 7(2): 237-243. doi:10.1161/circep.113.000805
21.Ling Z, McManigle J, Zipunnikov V, Pashakhanloo F, Khurram IM, Zimmerman SL, Philips B, Marine JE, Spragg DD, Ashikaga H, Calkins H, Nazarian S. The association of left atrial low-voltage regions on electroanatomic mapping with low attenuation regions on cardiac computed tomography perfusion imaging in patients with atrial fibrillation [J]. Heart Rhythm.(IF: 5.225), 2015, 12(5): 857-864. doi:10.1016/j.hrthm.2015.01.015
22.Ling Z, Tandri H. Left ventricular scar in atrial fibrillation: cause or effect? [J]. J Am Coll Cardiol.(IF: 18.639), 2013, 62(23): 2215-2216. doi:10.1016/j.jacc.2013.08.692
23.Liu H, Chen W, Lai Y, Du H, Wang Z, Xu Y, Ling Z, Fan J, Xiao P, Zhang B, Wang J, Gyawali L, Zrenner B, Woo K, Yin Y. Selective Renal Denervation Guided by Renal Nerve Stimulation in Canine [J]. Hypertension.(IF:7.017), 2019, Hypertensionaha**. doi:10.1161/hypertensionaha.119.12680
24.Liu Z, Ling Z, Su L, Wu J, Lan X, Chen Y, Du H, She Q, Yin Y. The effect of different treatment strategies on left atrial size in patients with lone paroxysmal atrial fibrillation-a prospective cohort study [J]. J Interv Card Electrophysiol.(IF:1.534), 2008, 23(3): 167-173. doi:10.1007/s10840-008-9301-7
25.Lu J, Ling Z, Chen W, Du H, Xu Y, Fan J, Long Y, Chen S, Xiao P, Liu Z, Zrenner B, Yin Y. Effects of renal sympathetic denervation using saline-irrigated radiofrequency ablation catheter on the activity of the renin-angiotensin system and endothelin-1 [J]. J Renin Angiotensin Aldosterone Syst.(IF: 2.4), 2014, 15(4): 532-539. doi:10.1177/**06480
26.Lu J, Wang Z, Zhou T, Chen S, Chen W, Du H, Tan Z, Yang H, Hu X, Liu C,Ling Z, Liu Z, Zrenner B, Woo K, Yin Y. Selective proximal renal denervation guided by autonomic responses evoked via high-frequency stimulation in a preclinical canine model [J]. Circ Cardiovasc Interv (IF: 6.06), 2015, 8(6). doi:10.1161/circinterventions.115.001847
27.Shiyu S, Zhiyu L, Mao Y, Lin B, Lijia W, Tianbao Z, Jie C, Tingyu L. Polydatin up-regulates Clara cell secretory protein to suppress phospholipase A2 of lung induced by LPS in vivo and in vitro [J]. BMC Cell Biol.(IF: 3.485), 2011, 1231. doi:10.1186/1471-2121-12-31
28.Wang Y, Xu Y, Ling Z, Chen W, Su L, Du H, Xiao P, Liu Z, Yin Y. Radiofrequency catheter ablation for paroxysmal atrial fibrillation: outcomes during a 3-year follow-up period [J]. J Int Med Res.(IF: 1.351), 2019, 47(4): 1636-1648. doi:10.1177/8522
29.Wang Z, Chen S, Zhou T, Su L, Ling Z, Fan J, Chen W, Du H, Lu J, Xu Y, Tan Z, Yang H, Hu X, Li C, Yan X, Hu G, Liu C, Yin Y. Comparison of Saline-Irrigated Catheter vs. Temperature-Controlled Catheter for Renal Denervation in a Canine Model [J]. Am J Hypertens.(IF: 3.182), 2015, 28(12): 1434-1443. doi:10.1093/ajh/hpv051
30.Xiao P, Ling Z, Woo K, Du H, Su L, Liu Z,Yin Y. Renin-angiotensin system-related gene polymorphisms are associated with risk of atrial fibrillation [J]. Am Heart J.(IF: 4.023), 2010, 160(3): 496-505. doi:10.1016/j.ahj.2010.06.013
31.Xu Y, Xiao P, Fan J, Chen W, Du H, Ling Z, Liu Z,Su L, Woo K, Yin Y. Blood pressure elevation response to radiofrequency energy delivery: one novel predictive marker to long-term success of renal denervation [J]. J Hypertens.(IF: 4.209), 2018, 36(12): 2460-2470. doi:10.1097/hjh.1839
32.Yang D, Yuan J, Liu G, Ling Z, Zeng H, Chen Y, Zhang Y, She Q, Zhou X. Angiotensin receptor blockers and statins could alleviate atrial fibrosis via regulating platelet-derived growth factor/Rac1/nuclear factor-kappa B Axis [J]. Int J Med Sci.(IF: 2.333), 2013, 10(7): 812-824. doi:10.7150/ijms.5931
33.Yin Y, Dalal D, Liu Z, Wu J, Liu D, Lan X, Dai Y, Su L, Ling Z, She Q, Luo K, Woo K, Dong J. Prospective randomized study comparing amiodarone vs. amiodarone plus losartan vs. amiodarone plus perindopril for the prevention of atrial fibrillation recurrence in patients with lone paroxysmal atrial fibrillation [J]. Eur Heart J.(IF: 23.239), 2006, 27(15): 1841-1846. doi:10.1093/eurheartj/ehl135
34.Yubing W, Yanping X, Zhiyu L, Weijie C, Li S, Huaan D, Peilin X, Zengzhang L, Yuehui Y. Long-term outcome of radiofrequency catheter ablation for persistent atrial fibrillation [J]. Medicine (Baltimore)(IF:2.02), 2018, 97(29): e11520. doi:10.1097/md.1520
35.Zhigang W, Zhiyu L, Haitao R, Hong R, Qunxia Z, Ailong H, Qi L, Chunjing Z, Hailin T, Lin G, Mingli P, Shiyu P. Ultrasound-mediated microbubble destruction enhances VEGF gene delivery to the infarcted myocardium in rats [J]. Clin Imaging.(IF: 1.136), 2004, 28(6): 395-398. doi:10.1016/j.clinimag.2004.04.003
36.Zhong B, Liu Z, Su L, Lan X, Chen Y, Ling Z, Du H, Yin Y. Comparison of prognostic value of different risk score methods on outcome of acute coronary syndrome [J]. Clin Cardiol.(IF: 2.455), 2009, 32(8): 434-438. doi:10.1002/clc.20494
37.Zhong S, Shu S, Wang Z, Luo J, Zhong W, Ran H, Zheng Y, Yin Y, Ling Z. Enhanced homing of mesenchymal stem cells to the ischemic myocardium by ultrasound-targeted microbubble destruction [J]. Ultrasonics.(IF: 2.598), 2012, 52(2): 281-286. doi:10.1016/j.ultras.2011.08.013
38.Zhou Q, Zeng Y, Xiong Q, Zhong S, Li P, Ran H, Yin Y, Reutelingsperger C, Prinze FW, Ling Z. Construction of CNA35 Collagen-Targeted Phase-Changeable Nanoagents for Low-Intensity Focused Ultrasound-Triggered Ultrasound Molecular Imaging of Myocardial Fibrosis in Rabbits [J]. ACS Appl Mater Interfaces(IF: 8.456), 2019, 11(26): 23006-23017. doi:10.1021/acsami.9b05999



主讲课程
内科学：高血压
循环系统疾病：心律失常、心脏猝死
简体诊断学：心电图检查







研究方向
心肌纤维化的分子显像，心律失常，冠心病