杨轶轩
学术学位硕士生导师
副主任医师
**
yixuan.yang@hotmail.com
第二临床学院
学科信息
个人简介
杨轶轩，1975年生，男，副主任医师， 博士后。1998年获南京医科大学临床医学系学士学位，2006年获中南大学大学湘雅医院消化内科专业博士学位。2006年9月到重庆医科大学感染性疾病分子生物学教育部重点实验室从事博士后研究，2007年1月-2011年10月到新加坡国立大学蛋白组中心从事肿瘤定量蛋白质组研究。从硕士研究生开始从事肿瘤蛋白质组学研究工作，熟练掌握Itraq, SILAC, ICAT定量蛋白质组学前沿技术。已发表蛋白质组学相关SCI论文14篇。
代表性论文
(1) Wang L, Chen S, Zhang M, Li N, Chen Y, Su W, Liu Y, Lu D, Li S, Yang Y, Li Z, Stupack D, Qu P, Hu H, Xiang R.Legumain: A biomarker for diagnosis and prognosis of human ovarian cancer.J Cell Biochem. 2012 Mar 22. doi: 10.1002/jcb.24143.
(2) Tong SW, Yang YX, Hu HD, An X, Ye F, Hu P, Ren H, Li SL, Zhang DZ.Proteomic investigation of 5-fluorouracil resistance in a human hepatocellular carcinoma cell line.J Cell Biochem. 2012 May;113(5):1671-80.
(3) Ye F, Yang YX, Hu HD, Tong JB, Cai WJ, Zhang DZ, Hu P, Li SL, Ren H.Preparation of novel anti-ski monoclonal antibodies.Hybridoma (Larchmt). 2011 Aug;30(4):393-5.
(4) Ye F, Zhang H, Yang YX, Hu HD, Sze SK, Meng W, Qian J, Ren H, Yang BL, Luo MY, Wu X, Zhu W, Cai WJ, Tong JB.Comparative proteome analysis of 3T3-L1 adipocyte differentiation using iTRAQ-coupled 2D LC-MS/MS.J Cell Biochem. 2011 Oct;112(10):3002-14
(5) Yang Yixuan, Lim Shen Kiat, Choong Lee Yee, Lee Huiyin, Chen Yunhao,Chong Poh Kuan, Ashktorab Hassan, Wang Ting Ting, Salto-Tellez Manuel,Yeoh Khay Guan, and Lim Yoon Pin. Cathepsin S Mediates Gastric Cancer Cell Migration and Invasion via a Putative Network of Metastasis-Associated Proteins. Journal of Proteome research. 2010, 9 (9): 4767–4778 (SCI影响因子5.132)
(6) Yi-XuanYang, Zhi-Qiang Xiao, Zhu-Chu Chen,Gui-Ying Zhang,Hong Yi, Peng-FeiZhang,Jian-Ling li and Guo Zhu. Proteome analysis of multidrug resistance in vincristine-resistant human gastric cancer cell line SGC7901/VCR. Proteomics, 2006, 6(6): 2009-2021. (SCI影响因子4.426)
(7) Yang YX, Hu HD, Zhang DZ,Reng H. Identification of proteins responsible for the development of adriamycin resistance in human gastric cancer cells using comparative proteomics analysis. Journal of Biochemistry and Molecular Biology, 2007, 40(6):853-60. (SCI影响因子2.021)
(8) Yi-Xuan Yang, Zhu-Chu Chen, Gui-Ying Zhang, Hong Yi, and Zhi-Qiang Xiao. Asubcelluarproteomicinvestigationintovincristine-resistantgastriccancercellline.JournalofCellularBiochemistry.2008，Jun,104(3):1010-21. (SCI影响因子2.935)
(9) Yi-Xuan Yang,Xue-Feng Sun,Ai-Lan Cheng,Gui-Ying Zhang,Hong Yi,Yi Sun,Huai-Dong Hu,Peng Hu,Feng Ye,Zhu-Chu Chen,Zhi-Qiang Xiao. Increased expression of HSP27 linked to vincristine resistance in human gastric cancer cell line.J Cancer Res Clin Oncol. 2009,135(2):181-9. (SCI影响因子2.261)
(10) YI Hong， YANG YI-Xuan ,CHEN Zhu-Chu ,ZHANG Gui-Ying,ZHANG Peng-Fei, LI Jian-Ling,ZHU Guo ,XIAO Zhi-Qiang . Identifacation of multidrug resistance related proteins in human gastric cancer cells using proteomics technique. Progress in Biochemistry and Biophysics, 2006, 33 (3): 267-276. (共同第一作者, SCI影响因子0.193)
(11) SUN Yi YI Hong YANG Yi-Xuan ZHANG Peng-Fei LI Mao-Yu LI Jian-Ling Yang Fang XIAO Zhi-Qiang CHEN Zhu-Chu. Identification of Proteins Associated With p
(12) Zhang X, Xiao Z, Chen Z, Li C, Li J, Yanhui Y, Yang F, Yang Y, Oyang Y.Comparative proteomics analysis of the proteins associated with laryngeal carcinoma-related gene 1.Laryngoscope 2006,116(2):224-30. (SCI影响因子2.018)
(13) Feng XP, Chen ZC, Xiao ZQ, Yang HY, Zhu GQ, Zhu G, Yang YX ,Li M,Li C,Li MY,Li F,Zang PF，Xiao JY. Over expression of NM23-H1, DJ1 and TIM
(14) Yi Sun, Hong Yi, Peng-Fei Zhang, Mao-Yu Li, Cui Li, Feng Li, Fang Peng, Xue-Ping Feng, Yi-Xuan Yang, Fang Yang, Zhi-Qiang Xiao and Zhu-Chu Chen.Identification of differential proteins in nasopharyngeal carcinoma cells with p53 silence by proteome analysis. FEBS letters, 2007, 581(1): 131-139. (SCI影响因子3.541)
研究方向
肝病临床蛋白质组学
