张利莉
学术学位硕士生导师

主任医师
***


**@qq.com

第二临床学院





学科信息


个人简介
张利莉，女，主任医师，副教授，硕士研究生导师，2010年毕业于华中科技大学，美国mayo clinic 糖尿病代谢中心博士后，中华医学会糖尿病学会青年委员会委员，中华医学会内分泌学会糖尿病学组委员，中国医药教育协和营养医学专委会委员，重庆市医学会糖尿病专委会青年委员会副主任委员，重庆市医学会中西医结合内分泌专委会副主任委员，担任中华糖尿病杂志，国际内分泌代谢杂志，cytokine等多个杂志审稿人，world journal of diabetes 及Diabetes and Weight Management journal杂志编委，主要研究方向肥胖，代谢性脂肪肝等胰岛素抵抗相关疾病。承担国家自然科学基金、重庆市科委基金、教育部新教师联合基金、重庆市博士后基金等6项课题，作为主要参与人参与国家自然科学基金多项，以第一或通讯作者发表SCI论文8篇，发表多篇中文论著，参与SCI论文多篇，总影响因子300+。


论文情况
1. C Wang, M He, J Peng, S Li, M Long, W Chen, D Liu, G Yang, L Zhang. Increased plasma osteopontin levels are associated with nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus. Cytokine, 2018, 125, 154837.（SCI 通讯作者）
2. M He, C Wang, XH Long, JJ Peng, DF Liu, GY Yang, MD Jensen, L Zhang. Mesencephalic astrocyte-derived neurotrophic factor ameliorates steatosis in HepG2 cells by regulating hepatic lipid metabolism. World journal of gastroenterology, 2020, 26 (10), 1029.（SCI 通讯作者）
3. Shengbing Li, Cong Wang, Bo Wang, Li Liu, Liang Tang, Dongfang Liu, Gangyi Yang, Lili Zhang. Efficacy of low-level light therapy for treatment of diabetic foot ulcer: A systematic review and meta-analysis of randomized controlled trials，2018;143:215-224.（SCI 通讯作者）
4. Wei Qin, Zhou Baoyong, Yang Gangyi, Hu Wenjing, Zhang Lili, Liu Rui, Li Minyan, Wang Kuan, Gu Harvest F, Guan Youfei, Zhu Zhiming, Zheng Hongting, Peng Jun, Li Ling. JAZF1 ameliorates age and diet-associated hepatic steatosis through SREBP-1c -dependent mechanism. Cell Death Dis, 2018.8.28, 9(9): 859~859
5. Xu Xiaohui, Li Xiaoqiang, Yang Gangyi, Li Ling, Hu Wenjing, Zhang Lili, Liu Hua, Zheng Hongting, Tan Minghong, Zhu Danping. Circulating bone morphogenetic protein-9 in relation to metabolic syndrome and insulin resistance.2017,7(1): 0~17529
6. Zhang L, Yang M, Ren H, Hu H, Boden G, Li L, Yang G. GLP-1 analogue prevents NAFLD in ApoE KO mice with diet and Acrp30 knockdown by inhibiting c-JNK. Liver Int. 2013; 33:794-804.（SCI 第一作者）
7. Zhang L, Li L, Yang M, *Xu K, Boden G, Yang G.The rhPTH treatment elevates plasma secreted protein acidic and rich in cysteine levels in patients with osteoporosis. Osteoporos Int,24(3):1107-1112,2013（SCI 第一作者）
8. Zhang L, Yang M, Liu D, Guo C, Li L, Yang G. The rhPTH (1-34), but not elcatonin, increases bone anabolic efficacy in postmenopausal women with osteoporosis. Exp Clin Endocrinol Diabetes,120(6):361-366, 2012（SCI 第一作者）
9. Yang M, Zhang L（co-author）, Wang C, Liu H, Boden G, Yang G, Li L. Liraglutide increases FGF-21 activity and insulin sensitivity in high fat diet and adiponectin knockdown induced insulin resistance. PLoS One,7(11):e48392, 2012（第一作者）
10. Zhang L, Li L, Yang M, Liu H, *Yang G. Elevated circulating vaspin levels were decreased by rosiglitazone therapy in T2DM patients with poor glycemic control on metformin alone. Cytokine,56(2):399-402, 2011（SCI 第一作者）
11. Yang M, Liu R, Li S, Luo Y, Zhang Y, Zhang L, Liu D, Wang Y, Xiong Z, Boden G, Chen S, Li L,Yang G.Zinc-α2-Glycoprotein Is Associated With Insulin Resistance in Humans and Is Regulated by Hyperglycemia, Hyperinsulinemia, or Liraglutide Administration: Cross-sectional and interventional studies in normal subjects, insulin-resistant subjects, and subjects with newly diagnosed diabetes. Diabetes Care,36(5):1074-1082, 2013
12. Li Y, Li-Li Z, Qin L, Ying W. Plasma Interleukin-18/Interleukin-18 binding protein ratio in Chinese Patients with NAFLD. Hepatogastroenterology, 97, 103-106,2010
13. Yuan L; Luo X; Zeng M; Zhang Y; Yang M; Zhang L; Liu R; Boden G; Liu H; Ma ZA; Li L; Yang G. Transcription factor TIP27 regulates glucose homeostasis and insulin sensitivity in a PI3-kinase/Akt-dependent manner in mice. Int J Obes (Lond).2015,39, 949-958.
14. Tian J, Chen H, Jia F, Yang G, Li S, Li K, Zhang L, Wu J, Liu D.Trends in the Levels of Serum Lipids and Lipoproteins and the Prevalence of Dyslipidemia in Adults with Newly Diagnosed Type 2 Diabetes in the Southwest Chinese Han Population during 2003-2012. Int J Endocrinol. doi: 10.1155/2015/818075.
15. Luo X, Li K, Zhang C, Yang G, Yang M, Jia Y, Zhang L, Ma ZA, Boden G4, Li L. Central administration of vaspin inhibits glucose production and augments hepatic insulin signaling in high-fat-diet-fed rat. Int J Obes (Lond). 2016 , 40(6):947-54.



科研项目
1. National Science Foundation for Young Scientists of China (Grant No. **) Thesis: Mechanism of Tip27 in improving hepatic lipotoxicity by inhibiting TAK1/p38MAPK/JNK pathway
2. Doctoral Fund of Chongqing (Grant No. xm). Thesis: Mechanism of central nesfatin-1 in improving fatty acid metabolism
3. Doctoral Fund of Ministry of Education of China (Grant No. 005) Thesis: Mechanism of JAZF1 in improving hepatic insulin resistance by inhibiting TAK1 pathway
4. Natural Science Foundation Key Project of CQ cstc(Grant No. cstc2013jcyjA0067) Thesis: Mechanism of Tip27 in improving hepatic insulin resistance by inhibiting TAK1 pathway
5. Chinesse Society of Endocrinology (Grant No. **) Thesis: Mechanism of Tip27 in improving hepatic lipotoxicity by inhibiting TAK1 pathway
6. Natural Science Foundation Project of Chongqing CSTC (cstc2018jcyjAXO210)



主讲课程
糖尿病 （中英文）

骨质疏松症
痛风
甲亢
内分泌总论
腺垂体功能减退



指导研究生情况(近五年)
共招收5名研究生，2名科研型，3名临床型，毕业一名科研型研究生（发表SCI论文2篇）

著作教材
系统整合教材
临床用药速查







研究方向
肝胰岛素抵抗的临床与基础研究