丁裕斌
学术学位博士生导师

教授
**


dingyb@cqmu.edu.cn

公共卫生与管理学院





学科信息


个人简介
丁裕斌，博士，教授/博士生导师，曾赴香港大学（郑裕彤博士奖学金资助）、美国匹兹堡大学（国家留学基金委公派博士后项目资助）和瑞典梅拉达伦大学学习，入选重庆市“高校中青年骨干教师”、留学人员回国创业创新支持计划（优秀）、重庆医科大学“****—骨干人才”等人才支持项目资助。“生殖与发育教育部国际合作联合实验室”学术骨干，NSFC、英国研究理事会（RCUK）评审专家。在Hum Reprod，Nucleic Acid Research，FASEB Journal，等杂志共发表SCI论文50余篇（第一或通讯作者27篇）。主持国家重点研发计划（分题）1项、国家自然科学基金4项、省部级（重庆市）4项、重庆市教委等自然科学、教改和横向合作等研究项目19项，资助总额430余万元。主研国家级、省部级项目20余项。指导本科生获国家级创新论坛/设计大赛一等奖和二等奖各1项。参编教材及专著2部。


科研项目
主持的科研项目
重庆医科大学“****-骨干人才”资助项目，100万元，起止时间2020.09-2023.08。

“双面”角色蛋白HMGB1通过核-浆双途径调控子宫内膜蜕膜化的机制及在反复流产中的作用研究，国家自然科学基金 NSFC，金额：55.0万元，No.**，起止日期：2020.01-2023.12
子宫容受性的建立与反复植入失败，科技部重点研发计划，金额：60.0万元，No.2018YFC**，骨干，起止日期：2019.01-2021.12
缺氧经DNA甲基化途径致滋养细胞合体化异常的分子机制及在子痫前期发生中的作用，国家自然科学基金 NSFC，金额：57.0万元，No.**，起止日期：2017.01-2020.12
缺氧/复氧致DNA甲基化协同调控的滋养细胞间质转化（EMT）障碍在子痫前期发生中的作用及机制研究，国家自然科学基金 NSFC，金额：70.0万元，No.**，起止日期：2014.01-2017.12
绒毛外滋养细胞（EVT）侵袭行为DNA甲基化调控机制研究，国家自然科学基金 NSFC，金额：17.0万元，No.**，起止日期：2008.01-2010.12
ACBP调控的脂肪酸β-氧化在蜕膜化过程中的作用和机制，重庆市科委基础科学与前沿技术研究（一般），金额：10.0万元，No.cstc2018jcyjAX0533，起止日期：2018.07-2021.06
缺氧诱导DNA甲基化异常对滋养细胞合体化的影响及在子痫前期发生中作用，重庆市科委基础科学与前沿技术研究（一般），金额：5.0万元，cstc2017jcyJAX0410起止日期：2017.07-2020.06
表观修饰调控的TPD52在滋养细胞侵袭中的功能研究，重庆市科委自然科学基金，金额：5.0万元，No.cstc2011jjA10085，起止日期：2011.09-2014.07





论文情况
Duan FM^#, Fu Li-Juan^#, Wang YH, Adu-Gyamfi EA, Ruan LL, Xu ZW, Xiao SQ, Chen XM, Wang, YX, Liu TH*, Ding YB*. THBS1 regulates trophoblast fusion through a CD36-dependent inhibition of cAMP, and its upregulation participates in preeclampsia. Genes and Diseases. 2021,8(3): 353-363. DOI: 10.1016/j.gendis.2020.05.007 (IF₂₀₁₉=4.80)
Lamptey J, Li F*, Adu-Gyamfi EA, Chen XM, Czika A, Otoo A, Liu TH, Wang YX*, Ding YB*. Downregulation of fascin in the first trimester placental villi is associated with early recurrent miscarriage. Exp Cell Res. 2021 Jun 1;403(1):112597. doi: 10.1016/j.yexcr.2021.112597. (IF2019=3.38)
Hong-Lan Song, Tai-Hang Liu, Yong-Heng Wang, Fang-Fang Li, Ling-Ling Ruan, Enoch Appiah Adu-Gyamfi, Si-Chen Hu, Xue-Mei Chen, Yu-Bin Ding（导师）, Li-Juan Fu *. Appropriate expression of P57kip2 drives trophoblast fusion via cell cycle arrest. Reproduction. 2021 May 5;161(6):633-644. doi: 10.1530/REP-20-0638.(IF2019=3.24)
Ding-Yuan Liu^#, Ren-Yan Li^#, Li-Juan Fu, Enoch Appiah Adu-Gyamfi, Yin Yang, Ying Xu, Le-Tian Zhao, Tian-Feng Zhang, Hua-Qiong Bao, Xiao-Ou Xu, Xiao-Han Gao, Xue-Niu Yang*, Yu-Bin Ding*.SNP rs** of CYP2R1 is associated with serum vitamin D levels and recurrent spontaneous abortion (RSA): a case-control study.Arch of OB&GY. Published online 24 Feb, 2021. DOI: 10.1007/s00404-021-06004-y(IF₂₀₁₉=2.28)

Adu-Gyamfi EA, Czika A, Gorleku PN, Ullah A, Panhwar Z, Ruan LL, Ding YB*, Wang YX*. The Involvement of Cell Adhesion Molecules, Tight Junctions, and Gap Junctions in Human Placentation. Reprod Sci. 2021 Feb;28(2):321. doi: 10.1007/s43032-020-00397-y. (IF₂₀₁₉=2.616)
Tang J, Wu X, Mou M, Wang C, Wang L, Li F,Guo M, Yin J, Xie W, Wang X, Wang Y, Ding Y*, Xue W* and Zhu F*. GIMICA: host genetic and immune factors shaping human microbiota. Nucleic Acids Res. 2021 Jan 8;49(D1): D715-D722. doi: 10.1093/nar/gkaa851.(IF₂₀₁₉=11.501)
Adu-Gyamfi EA, Wang YX*, Ding YB*. The interplay between thyroid hormones and the placenta: a comprehensive review.Biology of Reproduction. 2020 Feb 12;102(1):8-17. doi: 10.1093/biolre/ioz182. (IF₂₀₁₉=3.32)

Adu-Gyamfi EA, Ding YB*, Wang YX*. Regulation of placentation by the transforming growth factor beta superfamily. Biology of Reproduction. 2020 Feb 12;102(1):18-26. doi: 10.1093/biolre/ioz186. (IF₂₀₁₉=3.32)
Peng W, Tong C, Li L, Huang C, Ran Y, Chen X, Bai Y, Liu Y, Zhan J, Tan B, Luo X, Wang H, Wen L, Zhang C, Zhang H,Ding Y*, Qi H*, Baker N P. Trophoblast proliferation and invasion regulated by ACTN4 is impaired in early onset preeclampsia. FASEB J. 2019; 33(5): 6327-6338. doi: 10.1096/fj.RR. (IF₂₀₁₈=5.595)
Adu-Gyamfi EA, Lamptey J, Duan FM, Wang YX, Ding YB*. The transforming growth factor β superfamily as possible biomarkers of preeclampsia: a comprehensive review. Biomarkers in Medicine. Published online 27 September 2019. doi: 10.2217/bmm-2019-0208. (IF₂₀₁₈=2.268)
Lan X, Fu LJ, Zhang J, Liu XQ, Zhang HJ, Zhang X, Ma MF, Chen XM, He JL, Li LB, Wang YX, Ding YB*. Bisphenol A (BPA) promotes trophoblast migration by increasing Integrin-β1 and MMP-9 via activating MAPK and PI3K signaling pathways and impairs mice placentation. Oncotarget. 2017, 8(31): 51507-51521. doi: 10.18632/oncotarget.17882. (IF₂₀₁₇=5.168)
Zhang X, Fu LJ, Liu XQ, Hu ZY, Jiang Y, Gao RF, Feng Q, Lan X, Geng YQ, Chen XM, He JL, Wang YX, Ding YB*. The NM23 regulates decidualization through PI3K-Akt-mTOR signaling pathways in mice and humans. Hum Reprod. 2016 Oct;31(10):2339-2351. (IF₂₀₁₆=5.02)
Feng Q, Hu ZY, Liu XQ, Zhang X, Lan X, Geng YQ, Chen XM, He JL, Wang YX, Ding YB*. The Stomatin-like protein 2 (Slp-2) is involved in endometrial stromal cell proliferation and differentiation during decidualization in mouse and human. Reproductive Biomedicine Online. 2017, 34(2):191–202. (IF₂₀₁₇=3.249)
Lan X, Fu LJ, Hu ZY, Feng Q, Liu XQ, Zhang X, Chen XM, He JL, Wang YX, Ding YB*. Methylated Oligonucleotide (MON) induced E-cadherin promoter hypermethylation and associated decreased expression contribute to the Motility and Invasion of Human Trophoblast. Reprod Fertil Dev. 2017, 29(8):1509-1520. DOI: 10.1071/RD16031（(IF₂₀₁₇=2.105）
Peng W, Chen Y, Luo X, Shan N, Lan X, Olson D, Zhang H, Ding YB * and Qi HB*. DNA methylation-associated repression of MEST/PEG1 gene expression contributes to the invasion of extravillous trophoblast cells. Placenta. 2016; 46:92-101. (IF₂₀₁₆= 2.759)
Wu PH, Chen XM, Liu XQ, He JL, Feng Q, Lan X, Zhang X, Geng YQ, Wang YX, DingYB*. Activation of TRAIL receptor genes expression following DNA demethylation in placental choriocarcinoma and transformed cell lines. reproduction, fertility and development. Reprod Fertil Dev.2016; 28(11) 1844-1853. (IF₂₀₁₆=2.656)
Ding YB, He JL, Chen XM, Liu XQ^#, Wang YX^#. LongSAGE analysis of gene expression profile in mice endometrium during the window of implantation. Mol Biol Rep. 2013; 40(1):651-663. (SCI, IF₂₀₁₂=2.506)
Gao RF, Liu XQ, Wang YX, Chen XM, Ding YB*, He JL ^#. The IGF2 expression in blood is not associated to its imprinting status in healthy pregnant Chinese women. Biological research. Biol Res 2012, 45(4): 351-356. (IF₂₀₁₂=1.129)
Long CL, He JL, Liu XQ, Chen XM, Gao RF, Wang YX, Ding YB*. Dietary folate deficiency in pseudopregnant mice has no effect on homeobox a10 promoter methylation or expression. Reproductive Sciences. 2012; 19(12): 1268-1275 (IF₂₀₁₂=2.064)
Ding YB, Long CL, Liu XQ, Chen XM, Guo LR, Xia YY, He JL*, Wang YX*. 5-Aza-2′-deoxycytidine leads to reduced embryo implantation and reduced expression of DNA methyltransferases and essential endometrial genes. PLoS ONE. 2012; 7(9): e45364. (IF₂₀₁₁=4.07)
Ding YB, He JL, Liu XQ, Chen XM, Long CL, Wang YX*. Expression of DNA methyltransferases in the mouse uterus during early pregnancy and susceptibility to dietary folate deficiency. Reproduction. 2012; 144 (1): 91-100. (IF₂₀₁₂=3.555)
Gao RF, He JL, Liu XQ, Ding YB*, Chen XM, Chen Q, Tan Y, Wang YX*. Evaluation of IGF2 Imprinting Status and the Levels of Folate Biomarkers in the Second Trimester Pregnant Chinese Women. J Reprod Med. 2011; 56 (5-6): 254-260. (IF₂₀₁₁=0.688)







研究方向
遗传学-胚胎植入