张雪梅
学术学位博士生导师

教授
**


apoe@163.com

检验医学院





学科信息


个人简介


科研项目

一种新型肺炎链球菌矿化纳米蛋白疫苗——疫苗的构建、热稳定性及其免疫保护效应研究，国家自然科学基金（No.**），2016.1-2019.12，项目负责人
转录因子FabT介导的肺炎链球菌荚膜多糖合成调控的分子机制，国家自然科学基金(No.**) ，2018.1-2021.12，项目负责人


论文情况
代表性论文：
1.Wang X, Yuan J, Wang H, Gan N, Zhang Q, Liu B, Wang J, Shu Z, Rao L, Gou X, Zhang H, Yin Y, Zhang X. Progranulin Decreases Susceptibility to Streptococcus pneumoniae in Influenza and Protects against Lethal Coinfection. J Immunol. 2019 Sep 13. pii: ji**. doi: 10.4049/jimmunol.**. [Epub ahead of print]
2.Ye W, Zhang J, Shu Z, Yin Y, Zhang X*, Wu K*. Pneumococcal LytR Protein Is Required for the Surface Attachment of Both Capsular Polysaccharide and Teichoic Acids: Essential for Pneumococcal Virulence. Front Microbiol. 2018 Jun 13;9:1199.
3.Wu J, Wu K, Xu W, Yuan T, Wang X, Zhang J, Min Y, Yin Y, Zhang X*. Engineering detoxified pneumococcal pneumolysin derivative ΔA146PLY for self-biomineralization of calcium phosphate: Assessment of their protective efficacy in murine infection models. Biomaterials. 2018 Feb;155:152-164.
4.Su Y, Li D, Xing Y, Wang H, Wang J, Yuan J, Wang X, Cui F, Yin Y, Zhang X*. Subcutaneous Immunization with Fusion Protein DnaJ-ΔA146Ply without Additional Adjuvants Induces both Humoral and Cellular Immunity against Pneumococcal Infection Partially Depending on TLR4. Front Immunol. 2017 Jun 12;8:686.
5.Zhang H, Kang L, Yao H, He Y, Wang X, Xu W, Song Z, Yin Y, Zhang X*. Streptococcus pneumoniae Endopeptidase O (PepO) Elicits a Strong Innate Immune Response in Mice via TLR2 and TLR4 Signaling Pathways. Front Cell Infect Microbiol. 2016 Feb 29;6:23.
6.Yao H, Zhang H, Lan K, Wang H, Su Y, Li D, Song Z, Cui F, Yin Y, Zhang X*. PurifiedStreptococcus pneumonia Endopeptidase O (PepO) Enhances Particle Uptake by Macrophages in a Toll-Like Receptor 2- and miR-155-Dependent Manner. Infect Immun. 2017 Mar 23;85(4). pii: e01012-16.
7. Zhang S, Wang J, Xu W, Liu Y, Wang W, Wu K, Wang Z, Zhang X. Antibacterial effects of Traditional Chinese Medicine monomers against Streptococcus pneumoniae via inhibiting pneumococcal histidine kinase (VicK). Front Microbiol. 2015 May 20;6:479.
8. Xu X, Wang H, Liu Y, Wang Y, Zeng L, Wu K, Wang J, Ma F, Xu W, Yin Y, Zhang X. Mucosal immunization with a live attenuated vaccine SPY1 induces humoral and Th2-Th17-Treg cellular immunity and protects against pneumococcal infection. Infect Immun. 2015 Jan;83(1):90-100.
9. Wu K, Huang J, Zhang Y, Xu W, Xu H, Wang L, Cao J, Zhang X*, Yin Y*. A novel protein RafX is important for common cell wall polysaccharide biosynthesis in Streptococcus pneumoniae : implications for bacterial virulence. J Bacteriol. 2014 Sep;196(18):3324-34.
10. Liu Y, Wang H, Zhang S, Zeng L, Xu X, Wu K, Wang W, Yin N, Song Z, Zhang X*, Yin Y*. Mucosal immunization with recombinant fusion protein DnaJ-ΔA146Ply enhances cross-protective immunity against Streptococcus pneumoniae infection in mice via IL-17A. Infect Immun. 2014 Apr; 82(4):1666-75.






研究方向
细菌致病机制、疫苗及抗菌药物研发