吴小红
专业学位硕士生导师

主任医师



@qq.com

口腔医学院





学科信息


个人简介
口腔医学博士、副教授、副研究员、主任医师、硕士研究生导师，现任重庆医科大学附属口腔医院修复教研室副主任，中华口腔医学会口腔材料学专业委员会委员、中华口腔医学会口腔修复学专业委员会青年委员、重庆市口腔医学会口腔修复学专业委员会副主委等学术职务。任重庆医科大学附属口腔医院侨联秘书长。
于四川大学华西口腔医学院获口腔本科和口腔修复硕士学位，之后获全额奖学金在英国曼切斯特大学牙学院获牙髓学&生物材料博士学位。从事口腔修复、材料等专业医教研工作，主要研究方向包括对口腔材料的生物相容性、化学、物理机械性能评价研究，新型口腔生物材料的研制与应用研究，口腔材料应用性能评价手段的开发研究与设计。
主持国家自然科学基金课题2项，重庆市科委课题、重庆市卫生局课题等6项；研究成果曾2次在国际学术会议上交流；发表学术论文30余篇，其中SCI收录论文10余篇（第一或通讯作者）。带有硕士研究生13名，已毕业9名。




科研项目
1. 国家自然科学基金：载柚皮苷微球Depot对骨质疏松性临界骨缺损修复的机制研究（**）
2. 重庆市科委课题：米诺环素纳米纤维膜支架修复牙周炎骨缺损的研究（cstc2017jcyjAX0215）
3. 重庆市渝中区科委课题：同轴电纺柚皮苷纳米纤维膜对骨质疏松状态下的骨缺损修复研究（**）
4. 国家自然科学基金：柚皮苷对骨质疏松状态下颅颌面骨缺损修复的机理研究（**/H1402）。
5. 重庆市科委课题：控释柚皮苷纳米纤维膜修复骨质疏松状态下骨临界缺损的研究(CSTC, 2010BB5102)。）
6. 重庆市卫生局课题：骨器官培养技术在检测抗骨质疏松药物作用的实验研究（2012-2-8）。
7. 重庆医科大学校级课题（资助国家科学基金预研项目：柚皮苷对骨质疏松状态下颅颌面骨缺损修复的机理研究（NSFYY201045）。
8. 重庆医科大学附属口腔医院院级课题：控释中药的诱导骨再生膜的研制。


论文情况


Huthayfa N.S Almassri, Yihui Ma, Zhang Dan, Zhang Ting, Yuting Cheng, Xiaohong Wu. Implant stability and survival rates of a hydrophilic versus a conventional sandblast, acid-etched implant surface: systematic review and meta-analysis. The Journal of the American Dental Association. 2020:151(6):444-453
Dan Zhang, Jinlin Song, Huthayfa N.S Almassri, Yihui Ma, Ting Zhang, Yuting Cheng, Xiaohong Wu. Effect of microsphere size on the drug release and experimental characterization of an electrospun naringin-loaded microsphere/sucrose acetate isobutyrate (SAIB) depot.Polymers for advanced technologies. 2020;1-12.
Yihui Ma, Jinlin, Song, Huthayfa N.S Almassri, Dan Zhang, Ting Zhang, Yuting Cheng, Xiaohong Wu. Minocycline-loaded PLGA Electrospun Membrane Prevents Alveolar Bone Loss in Experimental Peridontitis. Drug Delivery, 2020;27(1):151-160. DOI: 10.1080/**.2019.**.
Huthayfa N.S.Almassri, QiongyueZhang, XueYang, XiaohongWu,The effect of oral anti-inflammatory drugs on reducing tooth sensitivity due to in-office dental bleaching: A systematic review and meta-analysis, The Journal of the American Dental Association, 2019:150(10):e145-e157
Xue Yang, Huthayfa N. S. Almassri, Qiongyue Zhang, Yihui Ma, Dan Zhang, Mingsheng Chen, Xiaohong Wu, Electrosprayed naringin-loaded microsphere/SAIB hybrid depots enhance bone formation in a mouse calvarial defect model, Drug Delivery, 2019:26(1):137-146
Qiongyue Zhang, Yigong Zhang, David C. Watts, Huthayfa N. S. Almassri, Huaying Shao, Xue Yang,Yihui Ma, Dan Zhang, Xiaohong Wu, Electrospun Naringin-Loaded Beaded Nanofiber with Controlled Release Property forBone Tissue Engineering Applications, Sci. Adv. Mater, 201(11):1433–1442
XiaoJia Long, Li He, SuLing Li, Ling Tong, Lu Wang, FaXiang Wang, XiaoHong Wu, Expression of TLR1 in tongue squamous cell carcinoma and adjacent tissue, Int J Clin Exp Pathol, 2016;9(9):8997-9007
Nisha Mahato, XiaoHong Wu*, Lu Wang*，Management of peri-implantitis: a systematic review, 2010–2015，SpringerPlus, 2016 Feb 1;5:105
Xu Tong，Tao You，Lu Wang，Feng Deng，XiaoHong Wu，The function of naringin in inducing secretion of osteoprotegerin and inhibitingformation of osteoclasts. Evidence-Based Complementary and Alternative Medicine, 2016;2016:**
Yufeng Zhang, Lu Wang*, Feng Deng, Hongmei Qiu, XiaoHong Wu*. Determination of a critical size calvarial defect in the SAMP6 osteoporosis mouse model based on in vivo micro-CT and histological evaluation. Archives of Gerontology and Geriatrics, 2015,61(1):44-55
Yan Ji, Lu Wang, David C. Watts, Hongmei Qiu, Tao You, Feng Deng, XiaoHong Wu. Controlled-release naringin nanoscaffold forosteoporotic bone healing. Dental materials, 2014,30 ( 11): 1263–1273.
XiaoHong Wu, Lu Wang,Feng Deng, David C. Watts. Mouse calvarial defect Model: An approach for the micro-tomographic evaluation of polymer scaffolds. Microscopy Research and Technique, 2014,77(12): 1037–1043
Qiu HM, Yang JX, XiaoHong Wu, Li N, Liu D, Wang LJ, Qin LJ, Zhou QX.. Antidepressive effect of paroxetine in a rat model: upregulating expression of serotonin and norepinephrine transporter. Neuroreport,2013,24(10):520- 525
Muhanad M. Hatamleh, Xiaohong Wu, Ahmad Alnazzawi, Jason Watson, David Watts, Surface characteristics and biocompatibility of cranioplasty titanium implants following different surface treatments, Dental Materials, 2018;34(4):676-683
X Wu, DC Watts. Healing Potential of Mouse Calvarial Defect In Vitro. Tissue Engineering Part A,2009,15(5):O-1-O-29.
X Wu, F Deng, L Wang, DC Watts. Micro-tomographic evaluation of the bone cell interactions with a Silorane-based composite. Microscopy Research and Technique，2012,75(9):1176-1184.
X Wu, DC Watts. Bonding of a Silorane-based composite system to bone. Advanced Engineering Materials,2009,11(11):B204-B208.
X Wu, S Downes, DC Watts. Evaluation of critical size defects of mouse calvarial bone: an organ culture study. Microscopy Research and Technique, 2010,73(5):540-547.






研究方向
组织工程，药物缓释控释