重庆大学附属中心医院（重庆市急救医疗中心）副教授/副研究员


学习经历
1.2014/05-2017/01，美国波士顿大学医学院，影像学，硕士
2.2007/09–2010/06，北京协和医学院，生物化学与分子生物学专业，博士
3.2000/09–2007/07，哈尔滨医科大学，基础医学七年制专业，硕士
4.2000/09–2007/07，哈尔滨医科大学，基础医学七年制专业，学士


工作经历
1.2018/02-至今，重庆大学附属中心医院，副教授
2.2018/02-至今，重钢总医院，副研究员
3.2017/02-2017/12，美国波士顿大学医学院，高级研究员


研究方向、教学课程
研究领域：心血管疾病，非酒精性脂肪肝，糖尿病，氧化还原修饰，蛋白质组学


成果：1.文章2.专利3.项目4.获奖
(一）文章
1.Shao D^#, Yao CX^#, Kim M, Fry J, Costello C, Cohen R, Matsui R, Seta F, McComb M, Bachschmid MM*. Improved mass spectrometry-based assay reveals oxidative and metabolic stress as sirtuin-1 regulators.Redox Biol. 2019 Apr; 22: 101150.
2.Li D, Bai C, Zhang Q, Li Z,Shao D*, Li X*.β-1,3-Glucan/CR3/SYK pathway-dependent LC3B-II accumulation enhanced the fungicidal activity in human neutrophils.J Microbiol. 2019 Feb 5. doi: 10.1007/s12275-019-8298-1.
3. Zhang L^#, Song W^#, ShaoD, Zhang S, Desai M, Ness S,Roy S, Yi J*.Volumetric fluorescence retinal imaging in vivo over a 30-degree field of view by oblique scanning laser ophthalmoscopy (oSLO). Biomed Opt Express.2018, 9(1): 25-40.
4. Yoon S,Beermann ML, Yu B,Shao D, Bachschmid M, Miller JB*. Aberrant caspase activation in laminin-a2-deficient human myogenic cells is mediated by p53 and sirtuin activity. J Neuromuscul Dis. 2018, (5):59-73.
5.Shao D^#, Han J^#, Hou X, Fry J, Behring JB, Seta F, Long MT, Roy HK, Cohen RA, Matsui R*, Bachschmid MM*. Glutaredoxin-1 deficiency causes fatty liver and dyslipidemia by inhibiting sirtuin-1.Antioxid Redox Signal. 2017, 27(6): 313-27.
6.Shao Di^#,Song Weiye, Yi Ji,Bachschmid Markus.24th Annual Meeting of the Society-for-Redox-Biology-and-Medicine (SfRBM).2017.11.29-2017.12.2. Noninvasive Retinal Optical Imaging in Metabolic Diseases Mouse Models Using Optical Coherence Tomography
7.Han J*, Weisbrod RM,Shao D, Watanabe Y, Yin X,Bachschmid MM, Seta F, Janssen-Heininger YMW, Matsui R, Zang M, Hamburg NM, Cohen RA. The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells. Redox Biol. 2016,10(9): 306-19.
8.Yao C, Behring JB, Shao D,Sverdlov AL, Whelan SA, Eleaby A, Yin X, Siwik DA, Seta F, Costello CE, Cohen RA, Matsui R, Colucci WS, McComb ME*,Bachschmid MM*. Overexpression of catalase diminishes oxidative cysteine modifications of cardiac proteins.Plos One. 2015, 10(12): e**.
9.Shao D, Liu Y, Liu X, Zhu L, Cui Y, Cui A, Qiao A, Kong X, Liu Y, Chen Q, Gupta N, Fang F, Chang Y*. PGC-1 beta-regulated mitochondrial biogenesis and function in myotubes is mediated by NRF-1 and ERR alpha. Mitochondrion. 2010, 10(5):516-27.
10.Di Shao^#,Jingyan Han,XiuyunHou, Jessica Fry, Francesca Seta, Richard Cohen, Reiko Matsui, Markus Bachschmid. Glutaredoxin-1 Deficiency Causes Fatty Liver and Dyslipidemia.Free Radical Biology and Medicine, 2015.10, 87: 0-S27.
11.Shao D, Fry JL, Han J, Hou X, Pimentel DR, Matsui R, Cohen RA,Bachschmid MM*.A redox-resistant SirT1 mutant protects against hepatic metabolic and oxidant stress. JBC. 2014, 289(11): 7293-306.
12.Shao Di^#, Fry Jessica, Zee Rebecca, Kumar Vikas, Pimentel David, Cohen Richard,Bachschmid Markus.A Redox Insensitive Triple Cysteine Mutant of SirT1 Rescues Oxidative Stress induced Apoptosis. Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB), 2013.4.20-2013.4.24
13.Zhu L, Ke Y,Shao D, Cui Y, Qiao A, Liu X, Fang F*, Chang Y*.PPARγ co-activator-1α co-activates steroidogenic factor 1 to stimulate the synthesis of luteinizing hormone and aldosterone.Biochem J. 2010,432(3):473-83.
14.Zhu LL^#, Liu Y^#, Cui AF,Shao D, Liang JC,Liu XJ, Chen Y, Gupta N, Fang FD, Chang YS*.PGC-1alpha coactivates estrogen-related receptor-alpha to induce the expression of glucokinase.Am J Physiol Endocrinol Metab. 2010,298(6):E1210-8.
15.Kong XX, Wang R, Liu XJ, Zhu LL,Shao D, Chang YS, Fang FD*.Function of SIRT1 in physiology.Biochemistry (Mosc). 2009, 74(7):703-8.
(二）
(三）专利
无
(四）科研项目
1.国家自然科学基金青年项目，**，GLRX调控的PGC-1alpha脂肪酸beta氧化通路与非酒精性脂肪肝病的致病机制研究，2020/01-2022/12，20.5万元，主持。
2.重庆市自然科学基金面上项目，cstc2019jcyj-msxmX0735,GLRX通过脂肪酸beta氧化通路调控非酒精性脂肪性肝病的生成机制研究，2019/07-2022/06，20万元，主持。
(五）获奖
无



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