个人简介 林治华，教授，博士生导师。重庆市免疫协会副理事长，重庆市生物医学工程学会理事，重庆市十二五重点学科药学学科带头人，重庆市有突出贡献的中青年专家，重庆市科技创新领军人才，教育部新世纪优秀人才。1988.09-1992.07，获得成都科技大学无机化工学士学位；1997.09-2000.07,获得重庆大学物理化学专业硕士学位；2000.09-2003.07,获得中国人民解放军第三军医大学免疫学专业博士学位。2001.12-至今,重庆理工大学药学与生物工程学院教师。在《RSCadvances》、《Peptides》、《化学学报》等国内外重要学术期刊上发表研究论文90余篇，其中被SCI收录50余篇,发表论文共被他人引用1000余次；授权专利5件；获得2009年度中华医学科技奖一等奖1项（排第8）；获得2008年度高等学校科学研究优秀成果奖（科学技术）自然科学二等奖1项（排第1）；获得2008年度重庆市科技进步二等奖1项（排第4）。
研究领域 （1）免疫信息学与疫苗设计
（2）基于重要靶点的药物高通量筛选
承担的主要项目 [1] HPV16型E7抗原CTL表位模拟肽抗HPV感染的实验研究，国家自然科学基金面上项目，2012.01-2015.12，58 万，主持。
[2]基于CTL免疫识别的结构信息表达及构效关系建模，国家自然科学基金面上项目，2009.01-2011.12，30万，主持。
[3]高效树突状细胞靶向DNA疫苗激发抗宫颈癌免疫应答的实验研究,国家自然科学基金面上项目，2006.01-2008.12，27万，主持。
[4]基于非蛋白氨基酸设计合成CTL模拟表位及免疫学效应的研究，国家自然科学基金面上项目，2005.01-2007.12，24万，主持。
[5]核苷类似物干预下HBV准种全长序列变异模式及其选择特性研究，国家自然科学基金重点项目，2009.01-2012.12，180万，参与。
[6]教育部新世纪优秀人才支持计划项目，2006-2009，50万，主持。
[7]重庆市高校创新团队“计算机辅助药物设计与化学生物学”，2010-2013，60万，主持。
[8]重庆市科技创新领军人才支持计划项目，2014-2016，45万，主持。
[9]介导金黄色葡萄球菌免疫逃逸的目标分子及作用机制，重庆市科委重点自然基金项目,2013-2015，20万，主持。
[10]一种具有抗HBV活性的抗爱滋病药物抗HBV作用机制的研究，重庆市科委重点自然基金项目,2016-2018，20万，主持。
代表性成果 论文
1. Juan Wang, Mao Shu, XiaorongWen, Yuanliang Wang, Yuanqiang Wang, Yong Hu and Zhihua Lin*. Discovery ofvascular endothelial growth factor receptor tyrosine kinase inhibitors byquantitative structure–activity relationships, molecular dynamics simulationand free energy calculation. RSC Advances. 2016, 6(42), 35402-35415.
2. Mao Shu, Xiaoli Zai, BeinaZhang, Rui Wang, Zhihua Lin*. Hypothyroidism Side Effect in Patients Treatedwith Sunitinib or Sorafenib: Clinical and Structural Analyses. PLOS ONE.2016, Jan 19;11(1):e**.
3. Wang Yuanqiang, ZhouPengpeng, Lin Yong, Shu Mao, Hu Yong, Xia Qingyou, Lin Zhihua*. QuantitativePrediction of Class I MHC/Epitope Binding Affinity Using QSAR Modeling Derivedfrom Amino Acid Structural Information. Comb Chem High Throughput Screen. 2015,18(1): 75-82.
4. Yu Rui, Wang Juan, Wang Rui,Lin Yong, Hu Yong, Wang Yuanqiang, Shu Mao, Lin Zhihua*. Combined pharmacophoremodeling, 3D-QSAR, homology modeling and docking studies on CYP11B1 inhibitors.Molecules. 2015 Jan 9;20(1):1014-30.
5. Xiurong Li, Mao Shu,Yuanqiang Wang, Rui Yu, Shuang Yao and Zhihua Lin*. 3D-QSAR Analysis on ATRProtein Kinase Inhibitors Using CoMFA and CoMSIA. Current Computer-Aided DrugDesign, 2014, 10（4）, 327-334.
6. Yuanqiang Wang, Yong Lin,Mao Shu, Rui Wang, Yong Hu, Zhihua Lin*. Proteasomal cleavage site predictionof protein antigen using BP neural network based on a new set of amino aciddescriptor. Journal of molecular modeling, 2013,19(8):3045-3052.
7. Wenjuan Yang, Mao Shu, Yuanqiang Wang, Rui Wang, Yong Hu, Lingxin Meng,Zhihua Lin*. 3D-QSAR and docking studies of 3-Pyridine heterocyclic derivativesas potent PI3K/mTOR inhibitors. Journal of Molecular Structure, 2013, 1054:107-116.
8. Yongjun Ji, Mao Shu, yuangqiang Wang, Yong Hu, Yong Lin, zhihuaLin*. 3D-QSAR Studies of Azacycles CCR5 Antagonists Using CoMFA and TopomerCoMFA. Journal of molecular structure, 2013, 1045 (3): 35-41.
9. Shu Mao，Yu Rui, Zhang Yunru, WangJuan, Yang Li, Wang Li, Lin Zhihua*. Predicting the Activity ofAntimicrobial Peptides with Amino Acid Topological Information. Medicinal Chemistry,2013,9（1）：32-44.
10. Xingyan Luo, Mao Shu, Yuanqiang Wang, Jin Liu, Wenjuan Yang andZhihua Lin *.3D-QSAR Studies of Dihydropyrazole and Dihydropyrrole Derivativesas Inhibitors of Human Mitotic Kinesin Eg5 Bas ed on Molecular Docking. Molecules,2012, 17(2), 2015-2029.
11. Yuanqiang Wang, Yuan Ding, Haixia Wen, Yong Lin,Yong Hu, Ya Zhang,Qingyou Xia and Zhihua Lin*.QSAR Modeling and Design of Cationic AntimicrobialPeptides Based on Structural Properties of A mino Acids. Combinatorial Chemistry& High Throughput Screening, 2012, 15(4), 347-353.
12. Yuanqing Wang, XiaomingCheng, Yong Lin, Haixia Wen, Li Wang, Qingyou Xia, Zhihua Lin*. QuantitativePrediction of TAP and MHC Class I Binding Peptides using QSAR Modeling based onAmino Acid Structural Information. Current Computer-Aided Drug Design, 2012, 8(1),50-54.
13. Shu M, Zhang YR, Tian FF,Yang L, Lin ZH[??]. Molecular Docking and 3D-QSAR Research of BiphenylCarboxylic Acid MMP-3 Inhibitors. Chinese Journal of Structural Chemistry, 2012,31(3):443-451.
14. Mao Shu, Xiaoming Cheng, Yunru Zhang,Yuanqiang Wang, Yong Lin, LiWang, Zhihua Lin*.Predicting the activity of ACE inhibitory peptides with anovel mode of pseudo amino acid composition. Pro tein & Peptide Letters,2011,18(12):1233-1243.
15. Juan Wang, Xiao-Yu Wang, Mao Shu, Yuan-Qiang Wang, Yong Lin,Li Wang，Xiao-Ming Cheng, Zhi-Hua Lin*.QSAR Study on MHC Class I A alleles basedon the novel parameters of amino acids. Protein & Peptide Letters, 2011,18(9):956-963.
16. Jiankun Liu,Yuzhong Duan, Xiaoming Cheng, Xi Chen, Wei Xie, HaixiaLong, Zhihua Lin*, Bo Zhu. IL-17 is associated with poor prognosis and promotesangiogenesis via stimulating VEGF producti on of cancer cells in colorectalcarcinoma. Biochemical and Biophysical Research Communications. 2011,407(2):348-354.
17. Wang Yuanqiang, Zhang Heng,Lin Yong, Zhao Qi, Liu Hui, Zhang zhan, Lin Zhihua*. 3D-QSAR Studies onCaspase-mediated Apoptosis Activity of Phenolic analogues，Journal of Molecular Modelling, 2011，17(1)：1-8.
18. Xiaoyu Wang, Juan Wang, YongLin , Yuan Ding ,Yuanqiang Wang, Xiaoming Cheng, Zhihua Lin*. QSAR study onangiotensin-converting enzyme inhibitor oligopeptides based on a novel set ofsequence information descriptors. Journal of Molecular Modelling, 2011,17(7)：1599-1606.
19. Xie Rong-Kai, Long Hai-Xia,Cheng Xiao-Ming, Wang Yuan-Qiang, Lin Yong, Yang Ying, Zhu Bo, Lin Zhi-Hua*.Quantitative sequence-kinetics relationship in antigen-antiboby interactionkinetics based on a set of descriptors. Chemical Biology & Drug Design,2010，76(4)：345-349.
20. Hai-Xia Long,Yuan-QiangWang, Yong Lin, and Zhi-Hua Lin*. QSAR Study on ACE Inhibitors by Using OSC-PLSAlgorithm. Journal of the Chinese Chemical Society, 2010, 57,417-422.
21. Lin Zhi-Hua*, WangHuai-Liang, Zhu Bo, Wang Yuan-Qiang, Lin Yong,Wu Yu-Zhang. Estimation ofAffinity of HLA-A*0201 Restricted CTL Epitope Based on the SCORE Function. Protein& Peptide Letters,2009,16(5): 561-569.
22. Zhi-hua Lin*, Hai-xia Long,Zhu Bo, Yuan-qiang Wang, Yu-zhang Wu. New descriptors of amino acids and theirapplication to peptide QSAR study. Peptides,2008,29(10):1798-1805.
23. Yangdong He, Liwei Mao,Zhihua Lin, Yijing Deng, Yan Tang, Man Jiang,Wanling Li, Zhengcai Jia, JiangxueWang, Bing Ni, Yuzhang Wu. Identification of a common HLA-A*0201-restrictedepitope among SSX family members by mimicking altered peptide ligands strategy.Molecular Immunology, 2008,45:2455–2464.
24. Tang Y,Lin Z,Ni B,Wei J,Han J,Wang H,Wu Y. Analtered peptide ligand for naïve cytotoxic T lymphocyte epitope ofTRP-2(180-188) enhanced immunogenicity.Cancer Immunol Immunother.2007,56(3):319-29.
25. Ni B,Lin Z,Zhou L,Wang L,Jia Z,Zhou W,Diciommo DP,Zhao J,Bremner R,Wu Y. Induction ofP815 tumor immunity by DNA-based recombinant Semliki Forest virus or repliconDNA expressing the P1A gene.Cancer Detect Prev.2004,28(6):418-25.
26. Lin Zhihua*, Wu Yuzhang, ZhuBo, Ni Bing, Wang Li. Toward the Quantitative Prediction of T-Cell Epitopes:QSAR Studies on Peptides Having Affinity with the Class I MHC MolecularHLA-A*0201. Journal of Computational Biology, 2004,11(4): 683-694.
27. Lin Zhihua*, Liu Shushen, LiZhiliang. Molecular Modeling of Quantitative Structure Retention RelationshipStudies: Retention Behavior of Polychlorinated Dibenzofurans on GasChromatographic Stationary Phase of Varying Polarity by a Novel MolecularDistance Edge Vector. Journal of Chromatographic Science, 2002, 40(1):7~13.
28. 王娟,舒茂,林勇,胡勇,韩英子,林治华*. HPV16 E7抗原CTL表位拟肽设计及活性评价.生物化学与生物物理进展,2015, 42(12):1119~1127.
29. 林治华*,王槐亮,唐艳,吴玉章.计算机辅助筛选酪氨酸激酶相关蛋白TRP-2 CTL模拟表位.化学学报,2007,65(8):760~764.
30. 林治华*，胡勇，吴玉章. HLA-A*0201限制性CTL表位肽三维定量构效关系的研究.化学学报,2004,62(18):1693~1698.
专利：
1、林治华，舒茂，路亚阔，于蕊，孟令鑫。一种非蛋白氨基酸抗菌肽及其应用，（中国专利），ZL 5.5（2013）。
2、王远强，林治华，丁元，蔡家利，韩英子。一组动物源性阳离子抗菌肽及其应用。（中国专利），ZL7.4（2011）
3、林治华，马正伟，许雪青，朱波，王锐。4-(环己基)-胺基喹唑啉类化合物的应用，（中国专利），ZL9.9（2011）
4、朱波，林治华，王槐亮，龙海霞，程晓明，陈正堂。肿瘤抗原TRAG－3模拟表位肽及其应用，（中国专利）ZL4.5
5、朱波，龙海霞，林治华，陈正堂。与MHC－Ⅰ类分子结合的鼠Ⅲ型肝炎病毒多肽表位及应用。（中国专利），ZL2.8
获奖：
1、 林治华,吴玉章,朱波,唐燕,王莉,韩俊峰。蛋白质抗原表位结构特性与免疫学效应关系的研究，高等学校科学技术奖自然科学奖(教育部)，二等奖，2008。
2、 朱波，陈正堂，吴玉章，林治华，谢启超，邹岚，程晓明，陈芳琳，段玉忠。非小细胞肺癌免疫治疗基础及临床应用研究，重庆市科技进步奖，二等奖，2008.
3、 吴玉章、倪兵、李晋涛、万瑛、王莉、朱波、许桂莲、林治华、牟芝蓉、陈永文、白云、宋建勋。蛋白质抗原的免疫识别、应答及调节，中华医学科技奖，一等奖，2009.窗体底端