陈德朴教授

清华大学分析中心教授，博士生导师；

1970年3月毕业于清华大学工程化学系；

1988年7月在中国科学院化学所获得理学博士学位；

1995.7-1997.2在美国Miami大学高访；

发表论文约60余篇。

专业及研究领域：生命分析化学，生物材料化学；与生物芯片北京国家研究中心合作，进行芯片研究中DNA或蛋白质的高灵敏度检测、化学修饰与功能化。

正在研究的课题:

A. DNA、蛋白质分子的磁性功能化研究

采用溶胶－凝胶法与络合吸附法制备了表面包覆二氧化硅与上转换荧光纳米粒子的生物磁粒，再与DNA或蛋白质分子连接，制成荧光磁性修饰DNA或蛋白质分子。用于免疫分析及生物芯片研究中的生物分子的分离或检测。

B. 荧光纳米粒子标记法用于芯片DNA或蛋白质的光致发光检测

合成了ZnS包复的CdSe半导体纳米粒子（量子点），并将其共价交联于DNA、蛋白质等分子，用于DNA芯片、蛋白质芯片上生物分子的标记及检测。 量子点标记物克服了有机荧光染料的一些不足，因而具有很高的检测灵敏度。

上转换荧光纳米粒子是一类在红外光激发下，能发出可见荧光的材料。用于生物分子的分析检测，可大幅度降低检测背景，提高检测的灵敏度。合成了粒度均匀的NaYF4:Yb,Er; NaYF4:Yb,Ho; NaYF4:Yb,Tm; La2(MoO4)3:Yb,Er等上转换荧光纳米粒子，并用于芯片上生物分子的标记及检测。

此外，还合成了某些可在长波长下激发的荧光纳米粒子，如，掺杂Eu的CaS纳米粒子，长余辉荧光纳米粒子等，并探索了其作为荧光生物标记材料的可能性。

主要学术论文题录：
1. Huachang Lu , Guangshun Yi , Shuying Zhao , Depu Chen* , Liang-Hong Guo* and Jing Cheng, Synthesis and characterization of multi-functional nanoparticles possessing magnetic, up-conversion fluorescence and bio-affinity properties, J. Mater. Chem., 2004, 14, (Advance Article);

2. Y.H. Lin*, C.W. Nan, N. Cai, X.S. Zhou, H.F. Wang, D.P. Chen, Anomalous afterglow from Y2O3-based phosphor, J. Alloys & Compounds, 361(1-2),92-95, 2003;

3. Haifeng Wang, Yunqi Ma, Depu Chen*, Synthesis of Mn-doped ZnSiO4 rodlike nanoparticles through hydrothermal method, Mater. Chem. & Phys., 82(2), 414-418, 2003;

4. 马云麒，衣光舜，孙宝全，陈德朴*，SrAl2O4:Eu2+,Dy3+的上转换发光特性，光谱学与光谱分析，23(3), 435-437, 2003;

5. Y.H. Lin*, C.W. Nan, X.S. Zhou, J.B. Wu, H.F. Wang, D.P. Chen and S.M. Xu, Preparation and characterization of long afterglow M2MgSi2O7-based (M: Ca,Sr, Ba) photoluminescent phosphors, Mater. Chem. & Phys., 82(3), 860-863, 2003;

6. 孙宝全，衣光舜，赵淑英，陈德朴*，组织工程及材料进展，高分子材料科学与工程，19(4), 1-5, 2003;

7. Guangshun Yi, Baoquan Sun, Fengzhen Yang, Depu Chen*, Jing Cheng, Synthesis and characterization of high-efficient up-conversion phosphors: ytterbium and erbium co-dopped lanthanum molydbate, Chem. Mater., 14(7), 2910-2914, 2002;

8. Guangshun Yi, Baoquan Sun, Run Li, Depu Chen*, Yuxiang Zhou, Jing cheng, An improved method for efficient synthesis of dioctanoyl peroxide, Synth. Commun., 32(5), 767-770, 2002;

9. Baoquan Sun, Guangshun Yi, Depu Chen*, Yuxiang Zhou, Jing Cheng, Synthesis and characterization of strongly fluorescent europium-doped calcium sulfide phosphor nanoparticles, J. Mater. Chem., 12(4), 1194-1198, 2002;

10. Guangshun Yi, Baoquan Sun, Fengzhen Yang, Depu Chen* and Jing Cheng, An efficient way for the preparation of YF3:Yb,Tm up-conversion nanoparticles and their optical properties, Proc. Inter. Sym. on Bioanalysis, Biotechnology and Nanotechnology, Hunan University, P88, 2002.

11. 孙宝全， 徐咏蓝， 衣光舜， 陈德朴*， 半导体纳米晶体的光致发光性质及在生物分子标记中的应用， 分析化学， 30(10), 1130-1136, 2002;

12. Guangshun Yi, Baoquan Sun, Fengzhen Yang, Depu Chen*, Bionic synthesis of ZnS:Mn nanocrystals and their properties, J. Mater. Chem., 11(12), 2928-2929, 2001;

13. Baoquan Sun, Wenzhang Xie, Guangshun Yi, Depu Chen*, Yuxiang Zhou, Jing Cheng, Microminiaturized immunoassays using quantum dots as fluorescent label by laser confocal scanning fluorescence detection, J. Immun. Methods, 249(1-2), 85-89, 2001;

14. Baoquan Sun, Guangshun Yi, Shuying Zhao, Depu Chen*, Yuxiang Zhou, Jing Cheng, Solid substrate phosphorescent immunoassay based on bioconjugated nanoparticles, Anal. Letters, 34(10), 1627-1637, 2001;

15. Baoquan Sun, Guangshun Yi, Depu Chen*，Wenzhang Xie, Yuxiang Zhou, Jing Cheng, Detection labeled with quantum dots on DNA microarray biochip using laser confocal scanning. in Jian Song, Jing Cheng, eds. Proc. Inter. Conf. on Eng. & Tech. Sci., 2000, Session 8. Beijing: New World Press, 2000. 81;

16. Baoquan Sun, Wenzhang Xie, Guangshun Yi, Depu Chen*, Yuxiang Zhou, Jing Cheng, Detection labeled with quantum dots on DNA microarray using laser confocal scanning.in Jian Song, Jing Cheng, eds. Proc. Inter. Conf. on Eng. & Tech. Sci., 2000, Session 8. Beijing: New World Press, 2000. 82;

17. Depu Chen*, Baoquan Sun, New tissue engineering material, copolymers of cellulose and lactide: Their synthesis and characterization, Mater. Sci. & Eng. C, 11(1), 57-60, 2000;

18. Wuyi Zha, Depu Chen*, Weiyang Fei, The HPLC separation of fullerenes with 1-methylnaphthalene modified PSDVB resin, J. Liqid Chromatogr.& Relative Technology, 23, 1-11, 1999;

19. Depu Chen*, Baoquan Sun, New tissue engineering materials, copolymers of cellulose and lactide: Their synthesis and characterization, The 5th IUMRS Inter. Conf. on Adv. Mater., 1999, Beijing, China;

20. W.H.Xie, D.P.Chen, X.H.Fan, J.Li, P.G.Wang*, H.N.Cheng, R.G.Nickol, Lithium chloride as catalyst for the ring-opening polymerization of lactide in the presence of hydroxyl-containing compounds, J. Polym. Sci.: Part A: Polym. Chem., 37, 3486-3491, 1999;

21. Zhang,W, Xie,WH,…Chen,DP, Wang,PG*, Recent progress in glycochemistry and green chemistry, Curr. Org. Chem., 3(3), 241-267, 1999;

22. W. Xie, J. Li, D. Chen, P. G. Wang*, Ring-opening polymerization of β-butyrolactone by thermophilic lipases, Polymer Preprints, 38(2), 279-280, 1997;

23. Libing Yu, Depu Chen, Jun Li, Johnny Ramirez and Peng George Wang*, Simon G. Bott, Lanthanide-promoted reactions of aldehydes and amine hydrochlorides in aqueous solvent, synthesis of 2,3-dihydropyridinium and pyridinium derivatives, J. Org. Chem. 62(1), 208-211, 1997;

24. Libing Yu, Depu Chen, Jun Li, Peng George Wang*, Preparations, characterization and synthetic uses of lanthanide (III) catalysts supported on ion exchange resins, J. Org. Chem. 62(11), 3575-3581, 1997;

25. Wenhua Xie, Jun Li, Depu Chen, Peng George Wang*, Ring-opening polymerization of β-butyrolactone by thermophilic lipases, Macromolecules, 30(22), 6997-6998, 1997;

26. Libing Yu, Jun Li, Johnny Ramires, Depu Chen, Peng George Wang*, Synthesis of azasugars via lanthanide-promoted Aza Diels-Alder reactions in aqueous solution, J. Org. Chem., 62, 903-907, 1997;

27. Depu Chen, Libing Yu and Peng George Wang*, Lewis acid-catalyzed reactions in protic ,media, lanthanide-catalyzed reactions of indoles with aldehyde or ketones, Tetrahedron Lett., 37(26), 4467-4470, 1996.

28. Libing Yu, Depu Chen, Peng George Wang*, Aqueous Aza Diels-Alder reactions catalyzed by lanthanide(III) trifluormethanesulfonate, Tetrahedron Lett., 17(13), 2169-2172, 1996.

专利
1. 周玉祥，刘理天，陈恳, 陈德朴等，可单点选通式微电磁单元阵列芯片、电磁生物芯片及应用，中国专利, 申请号: 99104113.5, 1999. Y.X. Zhou, T.L. Liu, K.Chen, D.P. Chen, Individually addressable micro-electromagnetic unit array chips, PTC/US9921417, 1999; US application No.:09/3991299

2. 孙宝全，衣光舜，陈德朴，周玉祥，程京，用于生物材料标记的稀土纳米粒子、其制备方法及用途. 中国专利，申请号No.01109551. 2, 2001-03-30

3. 衣光舜，孙宝全，陈德朴，周玉祥，程京，一种纳米级钼酸镧基质的上转换荧光材料及其制备方法. 中国专利，申请号No.01134861. 5, 2001-11-16

4. DP Chen, X Xi, X Zhang, BQ Sun, WY Fei, YX Zhou, J Cheng, Processes for producing coated magnetic microparticles and uses thereof, PCT/US02/08798，01109870.8, 2001-3-20.

5. 张旭，谢欣，陈继明，陈德朴，费维扬，程京，利用固相载体从生物粒子中分离核酸的方法，中国专利，申请号01140445.0, 2001-12-7

6. 衣光舜，孙宝全，陈德朴，周玉祥，程京，一种纳米级氟化物基质的上转换荧光材料及其制备方法. 中国专利，申请号No.02116679.X, 2002-04-15

7. Guangshun Yi, Yue Ge, Wenjun Yang, Lianghong Guo, Depu Chen, Jing Cheng, nanometer-sized up-converting phosphor fluoride particles and process of preparation. PCT/CN03/00268, 2003-04-15.

8. 卢华昌，衣光舜，陈德朴，郭良宏，程京，一种纳米荧光磁粒及其制备方法，中国专利，申请号No. 03153215.2，2003-08-08

9. Huachang Lu, Guangshun Yi, Depu Chen, Liang-Hong Guo and Jing Cheng, Fluorescent Magnetic Nanoparticles and Process of Preparation, disclosure August 2003, Patent Cooperation Treaty, PCT/CN03/00666



主要著作
1. Guangshun Yi, Baoquan Sun, Depu Chen, Nanocrystalline Phosphors, An review chapter for the book of “Encyclopedia of Nanosicience and Nanotechnology”, edited by H.S.Nalwa, Academic Press, in Press. URL:http://www.aspbs.com/jnn

2. WH Xie, LB Yu, DP Chen, J Li, J Ramirez, NF Miranda, PG Wang, in chapter 8 of Green Chemistry, Frontiers in benign chemical syntheses and processes (p.129-149), ed. By PT Anastas and TC Williamson, Oxford University Press, Oxford, England, 1998.



联系方法：

陈德朴教授

北京海淀区清华大学化学系分析中心4322室

邮编：100084

电话：010-62781691;

传真：010-62782485;

Email: hxx-chendp@mail.tsinghua.edu.cn