陈永湘 副教授 博士生导师
地址：北京市海淀区清华大学生命科学新馆332 邮编：100084
Email：chen-yx@mail.tsinghua.edu.cn
电话：+86-
招生：本课题组每年招收博士生和硕士生，欢迎推免和报考！
教育背景2002 - 2007 清华大学化学系，博士（导师：李艳梅教授）
1998 - 2002 湖南大学化学化工学院，学士
工作履历2011 至今 清华大学化学系，副教授
2007 - 2011 德国马普分子生理所，博士后 （合作导师：Herbert Waldmann教授）
研究领域具有修饰的多肽和蛋白质合成及生物功能研究；
发展蛋白质标记和表面固定技术。
奖励与荣誉2008-2010 德国洪堡基金会博士后奖学金
2015 Asian Core Program/Advanced Research Network Lectureship Awards
学术成果
代表性论文：

1. Zhang SY, Sperlich B, Li FY, Al-Ayoubi S, Chen HX, Zhao YF, Li YM, Weise K, Winter R*, Chen YX* Phosphorylation Weakens but Does Not Inhibit Membrane Binding and Clustering of K-Ras4B ACS Chem. Biol., 2017, in press, DOI: 10.1021/acschembio.7b00165 (* corresponding author)
2. Shi L, Chen H, Zhang SY, Chu TT, Zhao YF, Chen YX*, Li YM* Semi-synthesis of murine prion protein by native chemical ligation and chemical activation for preparation of polypeptide-α-thioester J. Pept. Sci., 2017, in press, DOI: 10.1002/psc.3008
3. Chu TT, Gao N, Li QQ, Chen PG, Yang XF, Chen YX*, Zhao YF, Li YM* Specific knockdown of endogenous tau protein by peptide-directed ubiquitin-proteasome degradation Cell Chem. Biol., 2016, 23, 453-461 (front cover)
4. Li L, Zhang SY, Li YM, Chen YX*, Dual-Labeling of Ubiquitin Protein by Chemoselective Reactions for Sensing UCH-L3. Mol. BioSyst. 2016, 12, 1764-1467
5. He YH, Li YM, Chen YX* Phosphorylation regulates proteolytic efficiency of TEV protease detected by a 5(6)-carboxyfluorescein-pyrene based fluorescent sensor, Talanta, 2016, 150, 340-345
6. Chu TT, Li QQ, Qiu T, Sun ZY, Hu ZW, Chen YX*, Zhao YF, Li YM* Clearance intracellular high level of Tau protein directed by artificial synthetic hydrolase Mol. BioSyst., 2014, 10, 3081–3085 (back cover)
7. Zhao L, Hu ZW, Tong P, Chen YX*, Zhao YF, Li YM* “Addition of artificial salt bridge by Ile646Lys mutation in gp41 coiled-coil domain regulates six-helical bundle formation” Bioorg. Med. Chem. Lett., 2013, 23, 2727
8. Yi L^#. Chen YX^#, Lin PC, Schroder H, Niemeyer CM, Wu YW, Goody RS, Triola G, Waldmann H* Direct immobilization of oxyamine-modified proteins from cell lysates. Chem. Commun., 2012, 48, 10829-10831 (^# co-first author)
9. Chen YX, Triola G, Waldmann H, Bioorthogonal chemistry for site-specific labeling and surface immobilization of proteins, Acc. Chem. Res., 2011, 44, 762-773
10. Ismail S^#, Chen YX^#, Rusinova A^#Chandra A^#, Bierbaum M, Gremer L, Triola G, Waldmann H, Bastiaens P, Wittinghofer A*, Regulation of a GDI-like transport system for farnesylated cargo by Arl2/3-GTP, Nature. Chem. Biol., 2011, 7, 942-949
11. Chen YX^#, Koch S^#, Uhlenbrock K^#, Weise K, Das D, Gremer L, Brunsveld L, Wittinghofer A, Winter R, Triola G, Waldmann H*, Synthesis of the Rheb and K-Ras4B GTPases, Angew. Chem. Int. Ed., 2010, 49, 6090-6095
12. Chen YX, Zhao L, Huang ZP, Zhao YF, Li YM*, Facile synthesis of cyclopeptide -centered multivalent glycoclusters with “click chemistry” and molecular recognition study by surface plasmon resonance Bioorg. Med. Chem. Lett., 2009, 19, 3775-3778
13. Chen YX, Zhao W, Zhao L, Zhao YF, Li YM*, Facile synthesis of a pentasaccharide mimic of a fragment of the capsular polysaccharide of Streptococcus pneumoniaetype 15C, Carbohydr. Res., 2008, 343, 607-614
14. Chen YX, Du JT, Zhou LX, Liu XH, Zhao YF, Nakanishi H, Li YM*, Alternative O-GlcNAcylation and O-phosphorylation of Ser16 Inducing Different Conformational Disturbances to the N terminus of Murine Estrogen Receptor b, Chem. & Biol., 2006, 13, 937-944