胡跃飞 教授

清华大学化学系，北京 100084
email: yfh@mail.tsinghua.edu.cn
电话：
教育背景1988-1990美国南佛罗里达大学《分子设计和识别中心》，G. R. Newkome 教授课题组 博士后
1984-1987 南京大学化学系 理学博士
1980-1983 南京大学化学系 理学硕士
1977-1980 南京大学化学系 大学毕业
工作履历2002-至 今 清华大学化学系教授，博士生导师。
1996-2002 南京大学化学系教授，博士生导师。
1991-1996 美国华盛顿大学医学院 (St. Louis) 分子生物学和分子药理学系工作，Research Associate，D. F. Covey 教授课题组。
1987-1988 南京大学化学系讲师。
1983-1984 北京理工大学助教。
学术兼职中国化学会《化学学报》编委会委员 (1999- )
中国化学会《化学化学生物学专业委员会》委员 (2001- )
社会兼职中国化学会会员 (1997- )
研究领域生物有机化学 具有生物活性的复杂和天然化合物的设计、合成和性质研究
杂环化学 具有生物活性杂环化合物的合成和方法研究
不对称合成 手性化合物的合成和方法研究
药物化学 国家级新药的研制
奖励与荣誉1998年 教育部“跨世纪人才培养计划基金”获得者。
2000年 国家基金委“国家基金” 获得者。
2000年 中国化学会首届“有机合成奖” 获得者
学术成果已经发表的部分论文
Yanmei Dong, Rui Li, Jun Lu, Xuenong Xu, Xinyan Wang, Yuefei Hu*, An efficient kinetic resolution of racemic Betti base based on an enantioselective N,O-deketalization. J. Org. Chem., 2005, 70, 8617-8620. Cunde Wang, Xin Jiang, Haijian Shi, Jun Lu, Yuefei Hu* and Hongwen Hu, Optimization of the abnormal Beckmann rearrangement: Application to steroid 17-oximes. J. Org. Chem., 2003, 68, 4579-4581.
Rui Zhu, Lixin Xing, Xinyan Wang, Chuanjie Cheng, Bo Liu and Yuefei Hu*, Practical preparation of diosphenols by ring-opening of epoxyketones catalyzed by silica gel supported acids, Synlett 2007, 2267-2271.
Lixin Xing, Xinyan Wang, Chuanjie Cheng, Rui Zhu, Bo Liu and Yuefei Hu*, A solvent-controlled highly efficient Pd-C catalyzed hydrogenolysis of benzaldehydes to methylbenzenes via a novel “acetal pathway”, Tetrahedron2007, 63, 9382-9386.
Liya Cao, Jianwei Sun, Xinyan Wang, Rui Zhu, Haijian Shi, Yuefei Hu*, Total synthesis of (-)-elegansidiol by using an abnormal Beckmann rearrangement of Hajos ketone oxime as a key step, Tetrahedron 2007, 63, 5036-5041.
Chuanjie Cheng, Xinyan Wang, Lixin Xing, Bo Liu, Rui Zhu and Yuefei Hu*, An efficient and practical method for highly chemoselective hydrogenation of nitrobenzylaminesto aminobenzylamine hydrochlorid, Adv. Synth. Catal., 2007, 349, 1775-1780.
Yuefei Hu, Hua Fu, Chanjuan Xi and Yong Ju, Reagents for Modern Organic Synthesis—Properties, Preparations and Reactions (Book), Chemical Industry Publisher: Beijing 2006, 443 pp, Hardback, ISBN 7-5025-8542-7.
Shaozhong Wang,* Jia Pan, Yuefei Hu, Hongwen Hu, FeCl3-promoted intramolecular annulation of δ-keto nitriles:Facile approach to prepare 3-acetamido-2-pyridone derivatives. Synthesis 2005, 753-756.
Shaozhong Wang,Yanmei Dong, Xinyan Wang, Xiaoyi Hu, Jun O Liuand Yuefei Hu*, 3-Aryl-β-carbolin-1-ones as inhibitors fortumor cell proliferation: Synthesis and biological evaluation. Org. Biomol. Chem., 2005,3,911-916.
Xinyan Wang, Yanmei Dong, Jianwei Sun, Rui Li, Xuenong Xu and Yuefei Hu*, Nonracemic Betti base as a new chiral auxiliary: Application to total syntheses of enantiopure (2S,6R)-dihydropinidine and (2S,6R)-isosolenopsins. J. Org. Chem., 2005, 70, 1897-1900.
Shaozhong Wang, Liya Cao, Haijian Shi, Yanmei Dong, Jianwei Sun and Yuefei Hu*, Preparation of 2-pyridone-containing tricyclic alkaloid derivatives as potential inhibitors of tumor cell proliferation by regioselective intramolecular N- and C-acylation of 2-pyridone. Chem. Pharm. Bull., 2005, 53, 67-71.
Jianwei Sun, Yanmei Dong, Liya Cao, Xinyan Wang, Shaozhong Wang and Yuefei Hu*, Highly efficient chemoselective deprotection of O,O-acetals and O,O-ketals catalyzed by molecular iodine in acetone, J. Org. Chem., 2004, 69, 8932-8934.
Shaozhong Wang,Jianwei Sun,Gang Yu,Xiaoyi Hu,Jun O Liuand Yuefei Hu*, CuI catalyzed N-arylation of amide as a key step for the preparation of 3-aryl β-carbolin-1-ones, Org. Biomol. Chem., 2004, 1573-1574.
Yanmei Dong, Jianwei Sun, Xinyan Wang, Xuenong Xu, Liya Cao and Yuefei Hu*, Highly regioselective N-alky-lation of non-racemic Betti base: A novel one-pot synthesis of chiral N-methyl-N-alkyl Betti bases. Tetrahedron: Asymmetry 2004, 15, 1667-1672.
Gang Yu, Shaozhong Wang, Kai Wang Yuefei Hu* and Hongwen Hu, A novel approach to 1,2-dihydro-2-oxo-3-pyridinecarboxylic ester via aromatization induced by deamidation. Synthesis 2004, 1021-1028.
Xuenong Xu, Jun Lu, Yanmei Dong, Rui Li, Zongming Ge and Yuefei Hu*, An improved synthesis of chiral 1-[α-(1-azacycloalkyl)benzyl]-2-naphthols. Tetrahedron: Asymmetry 2004, 15, 475-479.
Xuenong Xu, Jun Lu, Rui Li, Zongming Ge, Yanmei Dong and Yuefei Hu*, Diastereopure preparation of α-benzotriazolyl 1-azacycloalka[2,1-b][1,3] oxazines and their application as versatile chiral precursors, Synlett2004, 122-124.
Shaozhong Wang, Gang Yu, Jun Lu, Kun Xiao, Yuefei Hu* and Hongwen Hu, A novel and regioselective tandem reaction between 2-acetamidoacetamide and chalcones promoted by Cs2CO3 for the preparation of 3-unsubstituted 4,6- diarylpyrid-2-ones. Synthesis 2003, 487-490.
Jun Lu, Xuenong Xu, Shaozhong Wang, Cunde Wang, Yuefei Hu* and Hongwen Hu, Novel preparation of non-racemic 1-[a-(1-azacycloalkyl)benzyl]-2-naphthols from Betti base and their application as chiral ligands in the asymmetric addition of diethylzinc to aryl aldehydes, J. Chem. Soc., Perkin Trans 1., 2002, 2900-2903.
Jun Lu, Xuenong Xu, Cunde Wang, Jiangang He, Yuefei Hu* and Hongwen Hu, Synthesis of chiral ligands derived from the Betti base and their use in the enantioselective addition of diethylzinc to aromatic aldehydes, Tetrahedron Lett., 2002, 43, 8367-8369.
Jie Wang,Xin Jiang, Ming Chen, Zongming Ge, Yuefei Hu* and Hongwen Hu, TFA catalyzed ring transformation of 4-hydroxycyclobutenone: TFA catalyzed ring transformation of 4-hydroxycyclobutenone: A facile and general route for preparation of 3-substituted 4-amino-2(5H)-furanones. J. Chem. Soc., Perkin Trans 1., 2001, 66-71.
Xin Jiang, Jie Wang, Jiaxin Hu, Zongming Ge, Yuefei Hu* and Hongwen Hu, Synthesis of (5a)-17-azaandrostan-3-ols and (5a)-17-aza-D-homoandrostan-3-ols and their N-acylated derivatives. Steroids 2001, 66, 655-662.
Jie Wang,Xin Jiang, Ming Chen, Yuefei Hu* and Hongwen Hu, A novel coupling reaction of cyclobutene-1,2-diones induced by low-valent titanium. J. Organomet. Chem., 2001, 629, 213-218.
Jiaxin Hu, Xin Jiang, Ting He, Jan Zhou, Yuefei Hu* and Hongwen Hu, Novel synthetic routes for nitrogen-bridged tricyclic derivatives of pyrrolo[2,1,5-cd] indolizine and pyrrolo[2,1,5-de]quinolizine derived from 2-acyl-N-(acylmethyl- ene)pyridinium halides. J. Chem. Soc., Perkin Trans 1., 2001, 1820-1825.
Feng Liang, Jiaxin Hu, Lande Zhang, Yuefei Hu* and Hongwen Hu, Preparation of pyrrolo[2,1,5-cd]indolizine derivatives by intramolecular condensation of 3-acyl-5-methylindolizines. J. Heterocyclic Chem., 2001, 38, 853-857.
Xin Jiang, Cunde Wang, Yuefei Hu* and Hongwen Hu, A practical and facile route for the preparation of 18-norandrostan-17-ones from androstan-17-ones using SmI2 promoted cyclization and dehydroxylation. J. Org. Chem., 2000, 65, 3555-3557.
D.F. Covey,*M. Han, A.S. Kumar, M.A.M. de la Cruz, E.S. Meadows,Yuefei Hu, A. Tonnies, D. Nathan, M. Coleman, A. Benz, A.S. Evers, C.F. Zorumski, S. Mennerick, Neurosteroid analogues. 8. Structure-activity studies of N-acylated 17a-aza-D-homosteroid analogues of the anesthetic steroids (3a,5a)- and (3a,5b)-3-hydroxypregnan-20-one. J. Med. Chem., 2000, 43, 3201-3204.
Lande Zhang,Feng Liang, Lingzhi Sun, Yuefei Hu* and Hongwen Hu, A novel synthesis of 3-unsubstituted indolizines. Synthesis 2000, 1733-1737.
Jian Zhou,Yuefei Hu* and Hongwen Hu, Synthesis of pyrrolo[2,1-a]phthalazines by 1,3-dipolar cycloaddition of phthalazinium N-ylides with alkenes in the presence of tetrakis-pyridine cobalt (II) dichromate. J. Heterocyclic Chem.,2000, 37, 1165-1168.
Bingxiang Wang, Jiaxin Hu, Xuechun Zhang, Yuefei Hu* and Hongwen Hu, Oxidant promoted 1,3-dipolar cycloaddition of benzimidazolium ylides to alkenes for preparation of 4H-pyrrolo[1,2-a]benzimidazole. J. Heterocyclic Chem., 2000, 37, 1533-1537.
Bingxiang Wang, Xuechun Zhang, Jun Li, Xin Jiang, Yuefei Hu* and Hongwen Hu, Preparation of 3-indolizincarboxamides and 3-indolizinecarbonitriles by 1,3-cycloaddition of N-cyanomethylpyridinium ylides with alkenes in the presence of TPCD or MnO2. J. Chem. Soc., Perkin Trans I, 1999, 1571-1575.
Jian Zhou, Yuefei Hu,* Hongwen Hu, The first approach to the synthesis of indolizines by intramolecular 1,5-dipolar cyclization of 2-(2-arylethenyl)pyridium ylides in the presence of tetrakis-pyridine cobalt (II) dichromate. Synthesis 1999, 166-170.
Yuefei Hu, L.L. Wittmer, M. Kalkbrenner, A.S. Evers, C.F. Zorumski, D.F. Covey*, Neurosteroid analogues 5. Enantiomers of neuroactive steroids and benz[e]indenes: total synthesis, electrophysiological effects on GABAA receptor function and anesthetic action in tadpoles. J. Chem. Soc., Perkin Trans I, 1997, 3665-3671.
Yuefei Hu, K.A. Yamada, D.K. Chalmers, D.P. Annavajjula, D.F. Covey*, Enantioselectivity synthesis of cyclothiazide analogues: Novel probes of the stereospecific actions of benzothiadizines at AMPA-type glutamate receptors. J. Am. Chem. Soc., 1996, 118, 4550-4559.
L.L. Wittmer, Yuefei Hu, M. Kalkbrenner, A.S. Evers, C.F. Zorumski, D.F. Covey*, Enantioselectivity of steroid-induced GABAA receptor modulation and anesthesia. Molecular Pharmacology 1996, 50, 1581-1586.
Yuefei Hu, C.F. Zorumski, D.F. Covey*, Neurosteroid analogues. 2. Total synthesis and electrophysiological evaluation of a benz[e]indene analogue of the anesthetic steroid alphaxalone. J. Org. Chem., 1995, 60, 3619-2635.
Yuefei Hu, P.C. Sherwin, D.F. Covey*, Synthesis of (17R)- and (17S)-hydroxy-14,15-secoandrost-4-en-15-yn-3-one and the X-ray structure of the (17S)-diastereomer. Steroids, 1995, 60, 491-496.
M. Han, Yuefei Hu, C.F. Zorumski, D.F. Covey*, Neurosteroid analogues. 3. Synthesis and electrophysiological evaluation of benz[e]indene congeners of neuroactive steroids having the 5b-cofiguation. J. Med. Chem., 1995, 38, 4548-4556.
Yuefei Hu,* Xudong Wei, Hongwen Hu, Tetrakis-pyridino-cobalt (II) dichromate Py4Co(HCrO4)2 (TPCD). in Encyclopedia of Reagents for Organic Synthesis, Ed. by L.A., Paquette, John Wiley & Sons, New York, 1995, Vol. 7, 4780-4781.
B.P. Schlegel, J.E. Pawlowski, Yuefei Hu, D.M. Scolnick, D.F. Covey, T.M. Penning*, Steroid mechanism-based inactivators and site-directed mutagenesis as probes for steroid hormone recognition by 3a-hydroxysteroid dehydrogenase. Biochemistry, 1994, 33, 10367-10374.
Yuefei Hu, D.F. Covey*, Synthesis of 1,10-seco-5a-estr-1-ynes: Potential mechanism-based inhibitors of 3a- and 3b-hydroxysteroid dehydrogenases. J. Chem. Soc., Perkin Trans. I, 1993, 417-422.
Xudong Wei, Yuefei Hu*, Tingshen Li, Hongwen Hu, A facile one-step synthesis of aromatic indollizines by 1,3-dipolar cycloaddition of pyridinium and related heteroaromatic ylides with alkenes in the presence of TPCD [Py4Co(HCrO4)2]. J. Chem. Soc., Perkin Trans. I, 1993, 2487-2489.
Yuefei Hu, C.F. Zorumski, D.F. Covey*, Structure-activity studies of ben[e]indenes modulation of GABA reception function. 1. The effect of 6-methyl substituted on electrophisiology activity. J. Med. Chem., 1993, 36, 3956-3967.
D.F. Covey*, Yuefei Hu, M.G. Bouly, K.D. Holland, N.T. Rodgers-Neame, K.E. Isenberg, C.F. Zorumski, Modulation of GABA receptor function by benz[e]indenes and phenanthrenes. J. Med. Chem., 1993, 36, 627-630.
已申请和批准的专利
胡跃飞，许学农，李锐，董艳梅，陆军，胡宏纹，1-(a-氨基苄基)-2-萘酚的缩酮 (醛) 化合物及其制法和用途，中国发明专利，申请号: **.5，受理日期：2002.12.26。
胡跃飞，陆军，许学农，王少仲，胡宏纹，手性化合物 S-(+)- 和 R-(-)- 1-(a-氨基苄基)-2-萘酚的制备方法，中国发明专利，申请号：**.1，受理日期：2001.09.04。公开日期：2002.05.15。
D.F. Covey, Yuefei Hu, C.F. Zorumski. Novel Tricyclic Steroid Analogs. European Patent. Patent No. **. Patent data: Jan. 31, 1996.
D.F. Covey, Yuefei Hu, M. Han, C.F. Zorumski, Benz[e]indene Compounds. United States Patent, Patent No. 5,434,274. Patent data: July 18, 1995. Int. Cl. C07D 317/72. U.S.Cl. 549/336.
D.F. Covey, Yuefei Hu, C.F. Zorumski, Tricyclic Steroid Analogs. United States Patent, Patent No. 5,292,906. Patent data: March 08, 1994. Int. Cl. C07C 69/74. U.S.Cl. 552/619.
D.F. Covey, Yuefei Hu, C.F. Zorumski, Tricyclic Steroid Analogs. United States Patent, Patent No. 5,344,826. Patent data: Sept. 06, 1994. Int. Cl. A01N 45/00. U.S.Cl. 514/167.
D.F. Covey, Yuefei Hu, C.F. Zorumski. Tricyclic Steroid Analogs. United States Patent, Patent No. 5,206,415. Patent data: April 27, 1993. Int. Cl. C07C 69/608. U.S.Cl. 560/117.