林金明，博士、教授、博士生导师
教育部“奖励计划”
微量分析测试方法与仪器研制北京市重点实验室主任
清华大学化学系，北京 100084
办公室：化学系何添楼321
实验室：何添楼329，330
Tel/Fax: (Office)
(Lab)
E-mail: jmlin@mail.tsinghua.edu.cn
测试服务：
(李海芳博士，质谱/色谱检测，清华大学分析中心)
(窦相南，荧光/紫外/原子吸收)
实验室秘书：(林海峰)
研究方向：生命与环境分析化学
研究组：http://www.linlab-tsinghua-edu.org
更新日期：2016年10月15日
个人简介：
林金明，工学博士，分析化学专业。1984年福州大学毕业，1992年在日本昭和大学国际交流基金的资助下前往该大学药学部从事访问研究。1994年获得日本政府奖学金转入东京都立大学攻读博士学位，1997年3月获得工学博士学位，同年留校任教，2000年入选中国科学院“”，受聘中科院生态环境研究中心研究员、博士生导师；2001年获得国家科学基金，2002年3月底回国工作，2004年入选清华大学“百名人才引进计划”，受聘清华大学化学系教授、博士生导师。2008年受聘教育部,2014年入选英国皇家化学会会士。目前主要从事微流控芯片质谱联用细胞分析、化学发光/荧光免疫分析、复杂样品前处理分析、空气负离子检测与健康评估等研究。已培养博士研究生43名（含联合培养，其中留学生2名）、硕士研究生28名、博士后11名（其中留学生3名）、访问10名（其中外国访问1名）。
学术兼职Trends in Analytical Chemistry (Elsevier), Contributing Editor (2007.01-)
Journal of Flow Injection Analysis (JAFIA, Japan), International Advisory Board (2007.01-)
International Journal of Analytical Chemistry (Hindawi), Editorial Board (2008.01-)
Talanta (Elsevier), Editorial Board, (2008.01-)
Recent Patents on Nanotechnology (Hindawi), Editorial Advisory Board (2008.01-)
Current Analytical Chemistry (Bentham), Associate Editor (2009.01-)
Luminescence (Wiley), Editorial Board (2009.01-2016.06)
Luminescence (Wiley), Associate Editor (2016.06-)
Toxicological & Environmental Chemistry (Taylor & Francis), Editorial Board (2011.01-2015.12)
Journal of Pharmaceutical Analysis (Xi’an Jiaoda and Elsevier), Associate Editor (2011.01-)
Chinese Chemical Letter(CCS, Elsevier), Editorial Board (2012.01-2015.12)
Chinese Chemical Letter(CCS, Elsevier), Editorial Board (2016.1-)
Analytica Chemica Acta(Elsevier), Editorial Board (2015.09-)
《分析试验室》副主编(2013.10-)
《分析化学》编委(2002.01-)
《环境科学》编委(2004.07-)
《分析试验室》编委(2003.07-)
《色谱》编委(2003.01-)
《分析科学学报》编委(2003.01-)
《化学通报》编委(2008.01-)
《生命科学仪器》编委(2004.01-)
《环境科学与技术》编委(2009.01-)
《食品安全质量检测技术》编委(2008.01-)
《应用化学》编委(2010.01-)
《中国科学：化学》编委(2013.01-)
中国化学会副秘书长(2011.01-2014.12)
中国化学会分析化学专业委员会副主任(2003.01-)
中国色谱学会理事(2003.07-)
北京市色谱学会理事(2004.08-)
中国预防医学会自由基专业委员会委员(2005.08-)
北京化工大学兼职教授(2001.09-)
福州大学兼职教授(2001.06-2006.05)
中国仪器仪表学会分析仪器分会第一届样品制备专业委员会副主任委员(2011.4.10-)
北京市食品安全分析测试工程技术研究中心学术委员会委员(2011.7.9-)
中国药学会药物分析专业委员会委员(2011.08-)
中国分析测试协会理事(2011.12.8-)
中国化学会产学研合作与促进委员会主任(2011.12-2014.12)
中国化学会质谱分析专业委员会秘书长兼副主任(2013.12-)
研究领域研究方向：生命与环境分析化学
1）微流控芯片质谱联用细胞分析
2）化学发光/荧光免疫分析
3）空气负离子检测与健康评估
4）复杂样品前处理与质谱分析
5）分析新仪器、新设备的开发与研制
（欢迎本系及外单位的师生加盟本研究组。每年接收博士生2名、硕士生1-2名、博士后2-3名、优秀访问1－2名。同时接收联合培养研究生）
讲授课程：
1）基础分析化学实验
2）环境分析化学
3）分析化学与现代社会（新生研讨课）
研究概况研究组主要仪器设备：
1）四级杆－飞行时间质谱联用仪Micro TOF-Q（布鲁克公司）
2）飞行时间质谱系统MALDI TOF Autoflex I（布鲁克公司）
3）GC/MS-QP2010气相色谱质谱联用仪（岛津公司）
4）LC-MS 2010液相色谱质谱分析仪（岛津公司）
5）化学发光免疫分析仪（GloRunner）
6）DMI4000B倒置显微镜（Leika）
7）超高速液相色谱装置（日立公司）
8）高效液相色谱1台（含荧光、紫外检测）（岛津公司）
9）高效液相色谱2台（日立公司）
10）高效液相色谱1台（安捷伦公司）
11）F-7000荧光光度计（日立公司）
12）FM-4荧光光谱仪（HORIBA公司）
13）U-3900紫外可见分光光度计（日立公司）
14）毛细管电泳仪（贝克曼公司）
15）PIA-1000便携式离子色谱仪（岛津公司）
14）多台进口及国产的化学发光分析仪
16）MCE-202 (MultiNA)芯片电泳DNA/RNA检测仪(岛津公司)
17）HPB9504微孔板发光仪（滨松公司）
18) 喷墨注射化学发光分析仪(自制，与Tokyo Metropolitan University合作成果)
19) 全自动化学发光流动注射分析仪(自制，863海洋课题成果)
20) 高效液相-离子阱-飞行时间质谱仪(LCMS-IT-TOF)(岛津公司)
21) MALDI TOF-TOF质谱(岛津公司)
奖励与荣誉1992中国化学会优秀青年化学奖
1998日本科学协会Sasakawa科学研究奖
2000日本分析化学会流动注射分析进步奖
2000入选中国科学院“”
2001日本分析化学会关东支部新世纪奖
2001获得国家科学基金
2004中国科学院“”终期评估优秀入选者
2004入选清华大学“百名人才引进计划”
2007获得国家自然科学基金海外青年合作基金
2008日本分析化学会、日本流动注射分析协会FIA Award for Science
2008日本气相色谱研究会成立50周年大会上获得“气相色谱研究贡献奖”
2008受聘教育部“奖励计划”
2009中国分析测试协会科学技术奖(CAIA奖)一等奖
2009国家质检总局“科技兴检奖”二等奖
2010Eli Lilly亚洲优秀研究生论文导师奖
2010中国分析测试协会科学技术奖(CAIA奖)一等奖
2010辽宁省科学技术奖三等奖
2011中国产学研合作促进会创新成果奖
**年度清华大学“纪念梅贻琦学术论文奖”二等奖
2013日本分析化学会气相色谱研究会2013年度色谱研究贡献奖
2013CJK杰出贡献奖（2013年中日韩分析化学研讨会）
2013北京市科学技术奖二等奖（排名第一，疾病标记物的化学发光免疫分析试剂盒的研制）
**年度中国分析测试协会科学技术奖（CAIA奖）一等奖
**年度清华大学“纪念梅贻琦学术论文奖”二等奖
2014仪器信息网“蜜蜂奖”
2014清华大学2013年度国际合作与交流暨港澳台工作先进个人
**年度清华大学“纪念梅贻琦学术论文奖”二等奖
2014英国皇家化学会会士
2015《中国科学》（化学）2014年度优秀编委
2015中国化学会分析化学委员会第八届“分析化学基础研究梁树权奖”
2016教育部自然科学奖二等奖（排名第一，超微弱化学发光基础理论与新方法研究）
2016“中国移动杯”暨第十届北京市发明创新大赛银奖
学术成果近期论著 (论文备有电子版，欢迎来电索取)

l 林金明，赵利霞，王栩 主编，《化学发光免疫分析》，化学工业出版社，北京，2008.
l 林金明 编著，《化学发光基础理论与应用》，化学工业出版社，北京，2004.
l 林金明，赵利霞，宋冠群 编著，《环境、健康与负氧离子》，化学工业出版社，2007.
l Ziyi He, Qiushui Chen, Fengming Chen, Jie Zhang, Haifang Li, Jin-Ming Lin*, DNA-mediated cell surface engineering for multiplexed glycan profiling using MALDI-TOF mass spectrometry, Chemical Science, 2016, 7, 5448 – 5452.
l Hui Chen, Qiang Gao, Jianzhang Li*, Jin-Ming Lin*, Graphene materials-based chemiluminescence for sensing, Journal of Photochemistry & Photobiology, C: Photochemistry Reviews, 2016, 27, 54–71.
l Syed Niaz Ali Shah, Yongzan Zheng, Haifang Li, and Jin-Ming Lin*, Chemiluminescence character of ZnS quantum dots with bisulphite-hydrogen peroxidesystem in acidic medium, J. Phys. Chem. C, 2016, 120, 9308-9316.
l Fengming Chen, Luyao Lin, Jie Zhang, Ziyi He, Katsumi Uchiyama, and Jin-Ming Lin^*, Single cell analysis using drop-on-demand inkjet printing and probe electrospray ionization mass spectrometry, Anal. Chem., 2016, 88 (8), 4354–4360.
l Jie Zhang, Fengming Chen, Ziyi He, Yuan Ma, Katsumi Uchiyama, Jin-Ming Lin*, A novel approach for precisely controlled multiple cell patterning in microfluidic chip by inkjet printing and the detection of drug metabolism and diffusion, Analyst, 2016, 141, 2940 – 2947.
l Qiushui Chen, Stefanie Utech, Dong Chen, Radivoje Prodanovic, Jin-Ming Lin,* and David A. Weitz*, Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet, Lab Chip, 2016, 16, 1346-1349.
l Jing Wu, Ziyi He, Qiushui Chen, Jin-Ming Lin*, Biochemical analysis on microfluidic chips, Trends in Analytical Chemistry, 2016, 80, 213–231.
l Yongzan Zheng, Xiangnan Dou, Haifang Li, and Jin-Ming Lin*, Bisulfate induced chemiluminescence of g-C₃N₄ nanosheets and enhanced by metal ions, Nanoscale, 2016, 8, 4933 – 4937.
l Wu Liu, Jin-Ming Lin*, Online monitoring of lactate efflux by multi-channel microfluidic chip-mass spectrometry for rapid drug evaluation, ACS Sensor, 2016, 1 (4), 344–347.
l Xuexia Lin, Ka-Ho Leung, Ling Lin , Luyao Lin , Sheng Lin , Chung-Hang Leung, Dik-Lung Ma, Jin-Ming Lin^*, Determination of cell metabolite VEGF165 and dynamic analysis of protein-DNA interactions by combination of microfluidic technique and luminescent switch-on probe, Biosensors and Bioelectronics, 2016, 79, 41-47.
l Qichen Zhuang, Shiqi Wang, Jie Zhang, Ziyi He, Haifang Li, Yuan Ma ^*, Jin-Ming Lin*, Nephrocyte-neurocyte interaction and cellular metabolic analysis on membrane-integrated microfluidic device, Science China Chemistry, 2016, 59(2), 243-254.
l Mingsha Jie, Hai-Fang Li*, Luyao Lin, Jie Zhang, Jin-Ming Lin*, Integrated microfluidic system for cell co-culture and simulation of drug metabolism, RSC Adv., 2016, 6, 54564-54572.
l Luyao Lin, Mingsha Jie, Fengming Chen, Jie Zhang, Ziyi He, Jin-Ming Lin^*, Efficient cell capturein agarose-PDMS hybrid chip for shaped 2d culture under temozolomide stimulation, RSC Advances, 2016, 6, 75215 – 75222.
l Qiushui Chen, Ziyi He, Wu Liu, Xuexia Lin, Jing Wu, Haifang Li, Jin-Ming Lin*, Engineering cell-compatible paper chips for cell culturing, drug screening and mass spectrometric sensing, Advanced Healthcare Materials, 2015, 4(15), 2291-2296.
l Xuexia Lin, Qiushui Chen, Wu Liu, Jie Zhang, Shiqi Wang, Zhixiong Lin, and Jin-Ming Lin*, Oxygen-induced cell migration and on-line monitoring biomarkers modulation of cervical cancers on a microfluidic system, Sci. Rep., 2015, 5, 9643 (7 Pages).
l Hui Chen, Ling Lin, Haifang Li, and Jin-Ming Lin^*, Aggregation-induced structure transition of protein-stabilized zinc/copper nanoclusters for amplified chemiluminescence, ACS Nano, 2015, 9 (2), 2173–2183.
l Xuexia Lin, Qiushui Chen, Wu Liu, Linglu Yi, Haifang Li, Zhihua Wang^*, and Jin-Ming Lin*, Assay of multiplex proteins from cell metabolism based on tunable aptamer and microchip electrophoresis, Biosensors and Bioelectronics, 2015, 63, 105-111.
l Jie Zhang, Jing Wu, Haifang Li, Qiushui Chen, Jin-Ming Lin*, An in vitro liver model on microfluidic device for analysis of capecitabine metabolite using mass spectrometer as detector, Biosensors and Bioelectronics, 2015, 68, 322–328
l Zhen Lin, Xiangnan Dou, Haifang Li, Yuan Ma, Jin-Ming Lin*, Nitrite sensing based on the carbon dots-enhanced chemiluminescence from peroxynitrous acid and carbonate, Talanta, 2015, 132, 457–462.
l Wu Liu, Qiushui Chen, Xuexia Lin, Jin-Ming Lin*, Online multi-channel microfluidic chip-mass spectrometry and its application for quantifying noncovalent protein-protein interactions, Analyst, 2015, 140, 1551-1554.
l Hui Chen, Ling Lin, Haifang Li, and Jin-Ming Lin*, Quantum dots-enhanced chemiluminescence: mechanism and application (Invited review), Coordination Chemistry Reviews, 2014, 263/264, 86–100.
l Xiangwei He, Qiushui Chen, Yandong Zhang, and Jin-Ming Lin*, Recent advances of microchip-mass spectrometry in biological analysis, Trends Anal. Chem., 2014, 53, 84-97.
l Yandong Zhang, Haifang Li, Yuan Ma, and Jin-Ming Lin*, Paper spray mass spectrometry based method for analysis of droplets in a gravity-driven microfluidic chip, Analyst, 2014, 139 (5), 1023 – 1029.
l Xuexia Lin, Qiushui Chen, Wu Liu, Haifang Li, and Jin-Ming Lin*, A portable microchip for ultrasensitive and high-throughput assay of thrombin by rolling circle amplification and Hemin/G-quadruplex system, Biosensors and Bioelectronics, 2014, 56, 71–76.
l Niejun Wang, Sifeng Mao, Wu Liu, Jing Wu, Haifang Li*, and Jin-Ming Lin*, Online monodisperse droplets based liquid-liquid extraction on a continuously flowing system by using microfluidic devices, RSC Adv., 2014, 4(23),11919-11926.
l Linglu Yi, Xueqin Xu*, Xuexia Lin, Haifang Li, Yuan Ma, Jin-Ming Lin*, High-throughput and automatic typing via human papillomavirus identification map for cervical cancer screening and prognosis, Analyst, 2014, 139 (13), 3330 – 3335.
l Jing Wu, Haifang Li*, Qiushui Chen, Xuexia Lin, Wu Liu, and Jin-Ming Lin*, Statistic single-cell analysis of cell cycle-dependent quantum dot cytotoxicity and cellular uptake using microfluidic system, RSC Adv., 2014, 4 (47), 24929 – 24934.
l Ruizhi Ning, Shiqi Wang, Jing Wu, Feng Wang^*, and Jin-Ming Lin^*, ZnO nanowire arrays exhibit cytotoxic distinction to cancer cells with different surface charge density: cytotoxicity is charge-dependent, Small, 2014, 10(20), 4113-4117.
l Wu Liu, Niejun Wang, Xuexia Lin, Yuan Ma and Jin-Ming Lin*, Interfacing micro-sampling droplets and mass spectrometry by paper spray ionization for online chemical monitoring of cell culture, Anal. Chem., 2014, 86 (14), 7128–7134.
l Bo-Tao Zhang, Hai-Fang Li, Xiaoxia Zheng, Yanguo Teng, Yan Liu^*, Jin-Ming Lin*, Preparation of durable graphene-bonded titanium fibers for efficient microextraction of phthalates from aqueous matrices and analysis with gas chromatography-mass spectrometry, J. Chromatogr. A, 2014, 1370, 9-16.
l Sifeng Mao, Jie Zhang, Haifang Li, Jin-Ming Lin*, A Novel Strategy for High throughput signaling molecule detection to study cell–to–cell communication, Anal. Chem., 2013, 85 (2), 868–876.
l Fengming Chen, Sifeng Mao, Hulie Zeng, Shuhua Xue, Jianmin Yang, Hizuru Nakajima, Jin-Ming Lin*, Katsumi Uchiyama*, Inkjet nano-injection for high-thoughput chemiluminescence immunoassay on multicapillary glass plate, Anal. Chem., 2013, 85 (15)，7413–7418.
l Dan Gao, Hongxia Liu, Jin -Ming Lin*, Yini Wang, Yuyang Jiang*, Characterization of drug permeability in Caco-2 monolayers by mass spectrometry on a membrane-based microfluidic device, Lab Chip, 2013, 13, 978-985.
l Chen Luo, Yuan Ma,*, Haifang Li, Fengming Chen, Katsumi Uchiyama, Jin-Ming Lin*, Generation of pico-liter droplets of liquid for electrospray ionization with piezoelectric inkjet, J. Mass Spectrom., 2013, 48, 321-328.
l Fengming Chen, Yandong Zhang, Yuri Nakagawa, Hulie Zeng, Chen Luo, Hizuru Nakajima, Katsumi Uchiyama*, Jin-Ming Lin*, A piezoelectric drop-on-demand generator for accurate sampling in capillary electrophoresis, Talanta, 2013, 107, 111-117.
l Qunyan Xiao, Huiling Gao, Qipeng Yuan, Chao Lu*, Jin-Ming Lin, High-performance liquid chromatography assay of cysteine and homocysteine using fluorosurfactant-functionalized gold nanoparticles as postcolumn resonance light scattering reagents, J. Chromatogr. A, 2013, 1274, 145-150.
l Dan Gao, Haifang Li*, Niejun Wang, Jin-Ming Lin*, Evaluation of the absorption of methotrexate on cells and its cytotoxicity assay by using an integrated microfluidic device coupled to mass spectrometer, Anal. Chem., 2012, 84(21),9230-9237.
l Hui Chen, Haifang Li, Jin-Ming Lin*, Determination of ammonia in water based on chemiluminescence resonance energy transfer between peroxymonocarbonate and branched NaYF₄:Yb³⁺/Er³⁺ nanoparticle, Anal. Chem., 2012, 84, 8871-8879.
l Xiangnan Dou, Zhen Lin, Hui Chen, Yongzan Zheng, Chao Lu, and Jin-Ming Lin*, Production of superoxide anion radicals as an evidence for carbon nanodots as electron donors by chemiluminescence method, Chem. Commun., 2013, 49(52), 5871– 5873.
l Qiushui Chen, Jing Wu, Qichen Zhuang, Xuexia Lin, Jie Zhang, and Jin-Ming Lin*, Microfluidic isolation of highly pure embryonic stem cells using feeder-separated co-culture system, Sci. Rep., 2013, 3, 2433(6 pages)
l Qiushui Chen, Jing Wu, Yan-Dong Zhang, Zhen Lin, Jin-Ming Lin*, Targeted isolation and analysis of single tumor cells with aptamer-encoded microwell array on microfluidic device, Lab Chip, 2012, 12(24), 5180-5185.
l Jing Wu, Qiushui Chen, Wu Liu, Yandong Zhang, Jin-Ming Lin*, Cytotoxicity of quantum dots assay on a microfluidic 3D-culture device based on modeling diffusion process between blood vessels and tissues, Lab Chip, 2012, 12, 3474-3480.
l Hui Chen, Ruibo Li, Haifang Li, Jin-Ming Lin, Plasmon-assisted enhancement of the ultraweak chemiluminescence using Cu/Ni metal nanoparticles, J. Phys. Chem. C, 2012, 116, 14796-14803.
l Fengming Chen, Zhen Lin, Yongzan Zheng, Hulie Zeng, Hizuru Nakajima, Katsumi Uchiyama, Jin-Ming Lin, Development of an automatic multi-channel ink-jet ejection chemiluminescence system and its application to the determination of horseradish peroxidase, Anal. Chim. Acta, 2012, 739, 77-82.
l Ruibo Li, Takayuki Kameda, Akira Toriba, Kazuichi Hayakawa, Jin-Ming Lin, Determination of benzo[a]pyrene-7, 10-quinone in airborne particulates by using a chemiluminescence reaction of hydrogen peroxide and hydrosulfite, Anal. Chem., 2012, 84(7), 3215-3221.
l Ruibo Li, Hui Chen, Ying Li, Chao Lu, Jin-Ming Lin, Enhancing effect of alcoholic solvent on hydrosulfite-hydrogen peroxide chemiluminescence system, J. Phys. Chem. A, 2012, 116(9), 2192-2197.
l Qiushui Chen, Jing Wu, Yandong Zhang, Jin-Ming Lin*, Qualitative and quantitative analysis of tumor cell metabolism via stable isotope labeling assisted microfluidic chip-electrospray ionization-mass spectrometry, Anal. Chem., 2012, 84(3), 1695-1701.
l Zhen Lin, Wei Xue, Hui Chen, Jin-Ming Lin, Classical oxidant induced chemiluminescence of fluorescent carbon dots, Chem. Commun., 2012, 48 (7), 1051 – 1053.
l Sifeng Mao, Dan Gao, Wu Liu, Huibin Wei, Jin-Ming Lin, Imitation of drug metabolism in human liver and cytotoxicity assay using a microfluidic device coupled to mass spectrometric detection, Lab Chip, 2012, 12(1), 219-226.