Jose C. PASTOR-PAREJA 研究员 1999
2004
2005-2011
2011-2012
2012-
西班牙阿利坎特大学，获生物学学士学位
西班牙马德里自治大学，获分子生物学博士学位
美国耶鲁大学 遗传系，博士后
美国耶鲁大学 遗传系，副研究员
清华大学生命科学学院，PI


● 研究兴趣、领域： 我们了解生物机体的一个主要的障碍是其在组织水平上的复杂性。基膜（basement membranes，BMs）是由高度保守的细胞外基质蛋白的聚合物，它与其组分为所有动物组织都提供了必要的结构性支持。在细胞的形态发生，细胞信号，免疫反应，细胞再生和肿瘤形成的过程中，基膜与其组分都起着关键的作用。我们在最近的研究中发现，基膜的两个重要的组成成分IV型胶原蛋白（Collagen IV）和串珠素（Perlecan），发挥相反的作用力来决定细胞和器官的形状。目前本实验室正在进行的几个项目，研究的就是基底膜各组分如何分泌并组装成多聚体及其在发育、再生和癌症中的作用。

● 代表性论文： 1. Ke H, Feng Z, Liu M, Sun T, Dai J, Ma M, Liu LP, Ni JQ, Pastor-Pareja JC#. (2018). Collagen secretion screening in Drosophila, supports a common secretory machinery and multiple rab requirements. Journal of Genetics & Genomics. 10.1016/j.jgg.2018.05.002
2. Dai J, Ma M, Feng Z, Pastor-Pareja JC*. (2017). Inter-adipocyte adhesion and signaling by Collagen IV concentrations in Drosophila. Curr Biol 27:1-12.
3. Ma M, Cao, Dai J, Pastor-Pareja JC*. (2017). Basement membrane manipulation in Drosophila wing discs affects Dpp retention but not growth mechanoregulation. Dev Cell 42:97-106.
4. Liu M, Feng Z, Ke H, Liu Y, Sun T, Dai J, Cui W, Pastor-Pareja JC#. (2017). Tango1 spatially organizes ER exit sites to control ER export. Journal of Cell Biology. 216:1035-59. (# corresponding author)
5. Zang Y, Wan M, Liu M, Ke H, Ma S, Liu LP, Ni JQ, Pastor-Pareja JC#. (2015). Plasma membrane overgrowth causes fibrotic collagen accumulation and immune activation in Drosophila adipocytes. eLife.10.7554/eLife.07187. (# corresponding author)
6. Pastor-Pareja JC#, Xu T#. (2013). Dissecting social cell biology and tumors using Drosophila genetics. Annual Review of Genetics. 47:51-74. (# corresponding author)
7. Pastor-Pareja JC, Xu T. (2011). Shaping cells and organs in Drosophila through the opposing effects of fat body-secreted Collagen IV and Perlecan. Developmental Cell. 21: 245-56
8. Wu M*, Pastor-Pareja JC*, Xu T. (2010). Interaction between RasV12 and scribbled clones induces tumor growth and invasion. Nature. 463: 545-8. (* equal contribution)
9. Pastor-Pareja JC, Wu M, Xu T. (2008). An innate immune response of blood cells to tumors and tissue damage in Drosophila. Disease Models & Mechanisms. 1: 144-54.
10. Srivastava A*, Pastor-Pareja JC*, Igaki T, Pagliarini R, Xu T. (2007). Basement membrane remodeling is essential for Drosophila disc eversion and tumor invasion. Proc Natl Acad Sci USA. 104: 2721-6. (* equal contribution)
11. Pastor-Pareja JC, Grawe F, Martin-Blanco E, Garcia-Bellido A. (2004). Invasive cell behavior during Drosophila imaginal disc eversion is mediated by the JNK signaling cascade. Developmental Cell. 7: 387-99.

● 联系方式： 通讯地址：清华大学医学科学楼D224，北京 100084
电话：（办公室） （实验室）
邮箱：josepastor@tsinghua.edu.cn
网址：http://joselab.life.tsinghua.edu.cn