郝艳丽 工程师


1999年毕业于郑州大学药学院，获得理学学士学位；2005年毕业于沈阳药科大学，获得药剂学专业博士学位；2005-2007年在在清华大学生物学博士后流动站从事博士后研究；2007年进入清华大学医学院工作。

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研究方向研究工作主要集中在新型纳米载体和聚合物载体作为药物递送系统的设计和应用。在最近的研究中，我们发展了新的配体修饰的阳离子聚合物载体系统，用于提高DNA或siRNA在EGFR高表达肿瘤细胞中的转染效率和表达效果。我们还研究利用纳米技术来提高难溶性药物的溶解性和生物利用度，赋予这些药物靶向、缓释特征。我们探寻通过利用这些纳米递送系统来提高药物的体内外输运效率，从而达到可以显著改善一些重大疾病例如癌症的治疗效果。

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论文发表1.Jun Li, Shengnan Li, Songyun Xia, Jinfeng Feng, Yanli Hao*, Lei Chen*, Xiaoning Zhang*. 2015. Enhanced transfection efficiency and targeted delivery of self-assembling h-R3-dendriplexes in EGFR-overexpressing tumor cells. Oncotarget, Early Online, 6: 26177-91.
2.Jun Li, Lei Chen, Nan Liu, Shengnan Li, Yanli Hao*, Xiaoning Zhang*. 2015. EGF-coated nano-dendriplexes for tumor targeted nucleic acid delivery in vivo. Drug Delivery, 25:1-8.
3.Yanli Hao*, Lan Wang, Jun Li, Nan Liu, Jinfeng Feng, Mojiao Zhao, Xiaoning Zhang*. 2015. Enhancement of solubility, transport across MDCK monolayer and oral absorption of pranlukast by preparing pranlukast-phospholipid complex. J. Biomedical Nanotechnology, 11(3): 469-477(9)
4.Anil Kumar, Fei Chen, Anbu Mozhi,Xu Zhang, Yuanyuan Zhao, Xiangdong Xue, Yanli Hao, Xiaoning Zhang, and Xing-Jie Liang*. 2013. Innovative pharmaceutical development based on unique properties of nanoscale delivery formulation. Nanoscale, 5:8307-8325.
5.Zhe Yin, Nan Liu, Mingshu Ma, Lan Wang, Xing-Jie Liang, Yanli Hao*, Xiaoning Zhang*. 2012. A novel EGFR-targeted gene delivery system based on complexes self-assembled by EGF, DNA and activated PAMAM dendrimers, In J Nanomedicine 7, pp 4625-4635.
6.Nan Liu, Yanli Hao*, Zhe Yin, Mingshu Ma, Lan Wang, Xiaoning Zhang*. 2012. Self-Assembled Human Serum Albumin-Coated Complexes for Gene Delivery with Improved Transfection. Die Pharmazie, 67(2): 174-181.
Mingshu Ma, Yanli Hao*, Nan Liu, Zhe Yin, Lan Wang, Xing-Jie Liang, Xiaoning Zhang*. 2012. A novel lipid-based nano-micelle of docetaxel: evaluated antitumor efficiency and biodistribution with optical imaging in vivo. In J Nanomedicine,7, pp 3389-3398.
7.Lan Wang, Yanli Hao*, Nan Liu, Zhe Yin, Mingshu Ma, Xiaoning Zhang*. 2012. Enhancethedissolutionrateandoralbioavailabilityofpranlukastbypreparingnanosuspensionswithhigh-pressurehomogenizingmethod. Drug Development and Industrial Pharmacy, 38(11):1381-1389.
8.Chunlei Li, Jingxia Cui, Yingui Li, Caixia Wang, Yanhui Li, Lan Zhang, Li Zhang, Wenmin Guo, Jinxu Wang, Hongwu Zhang, Yanli Hao, Yongli Wang. 2008. Copper ion-mediated liposomal encapsulation of mitoxantrone:The role of anions in drug loading, retention and release. Eur. J Pharm. Sci, 34(4-5):333-344.
Jingxia Cui, Chunlei Li, Yanhui Li, Caixia Wang, Li Zhang, Lan Zhang, Yanli Hao,Yongli Wang. 2007. Direct comparison of two pegylated liposomal doxorubicin formulations: Is AUC predictive for toxicity and efficacy? J Controlled Release, 118(2):204-215.
9.Aijun Hao, Yingjie Deng, Tiefu Li, Xubin Suo, Yanhai Cao, Yanli Hao, Yong Zhang. 2006. Degradation kinetics of fluorouracil-acid-dextran conjugate in aqueous solution. Drug Development and Industrial Pharmacy, 32(6):757-763.
10.Yanli Hao, Yingjie Deng, Yan Chen, Kezhan Wang, Aijun Hao and Yong Zhang. 2005. In vitro cytotoxicity, in vivo biodistribution and anti-tumor effect of PEGlyated liposome containing topotecan. J Pharmacy and Pharmacology, 57: 1279-1287.
11.Yanli Hao, Yingjie Deng, Yan Chen, Xiumin Wang, Haijun Zhong and Xubin Suo. 2005. In-Vitro and In-Vivo Studies of Different Liposomes Containing Topotecan. Archives of Pharmacal Research, 28(5): 626-635.
12.Yanli Hao, Yingjie Deng, Yan Chen and Youcai Hu. Synthesis 3-4-2-hydroxyl-(1-methyl ethylamine) propyl oxygen}phenyl}propionic acid cetylester as Potential Ligand for Liposome Targeting to Ischemic Myocardium. Chinese Chemical Letters, 16(8):1004-1006.
13.Yan Chen, Yingjie Deng, Yanli Hao. 2005. Surface modification of liposomes for selective cardiomyocytes targeting in vitro. Die Pharmazie, 60(3): 238-240.
14.Yan Chen, Yingjie Deng, Yanli Hao, Aijun Hao, Haijun Zhong and Xiumin Wang. 2005. Uptake of liposomes by cultured cardiomyocytes. Die Pharmazie, 60(11):844-848.