俞立博士
教授博导
1994四川大学生物系微生物专业学士
2000北京大学生命科学学院分子生物学专业博士
2000~2008美国国立卫生研究院博士后
2008~至今清华大学生命科学学院教授
主要科研领域与方向
综合细胞生物学，生物化学，系统生物学等手段，利用从酵母到小鼠等不同模式生物研究1）自吞噬在细胞及分子水平上的调控机制2）细胞程序性死亡3）细胞器的产生，运动的分子机制。
SelectedPublications

YueguangRong,MeiLiu,LiangMa,WanqingDu,HanshuoZhang,YuanTian,ZhenCao,YingLi,HeRen,ChuanmaoZhang,LinLi,SheChen,JianzhongXi*&LiYu*Clathrinandphosphatidylinositol4,5-bisphosphateregulateautophagiclysosomereformation.NatureCellBiology.2012Aug12,10.1038/ncb2557(LiYuascorrespondingauthor)

CongYi,MeishengMa,LeiliRan,JingxiangZheng,JingjingTong,JingZhu,ChengyingMa,YufenSun,ShaojinZhang,WenzhiFeng,LiyuanZhu,YanLe,XingqiGong,XianghuaYan,BingHong,Fen-JunJiang,ZhipingXie,DiMiao,HaitengDeng&LiYu*Functionandmolecularmechanismofacetylationinautophagyregulation.Science.2012Apr27,474-477(LiYuascorrespondingauthor)

HuangW,ChoiW,HuW,MiN,GuoQ,MaM,LiuM,TianY,LuP,WangFL,DengH,LiuL,GaoN,YuL*,ShiY*.CrystalstructureandbiochemicalanalysesrevealBeclin1asanovelmembranebindingprotein.CellRes.2012Feb7,(LiYuasco-correspondingauthor)

MaX,WuY,JinS,TianY,ZhangX,ZhaoY,YuL*,LiangXJ*.Goldnanoparticlesinduceautophagosomeaccumulationthroughsize-dependentnanoparticleuptakeandlysosomeimpairment.ACSNano.2011Nov22;5(11):8629-39.Epub2011Oct11.(LiYuasco-correspondingauthor)

YueguangRong,ChristinaK.McPhee,ShuangshenDeng,LeiHuang,LilianChen,MeiLiu,KirstenTracy,EricH.Baehrecke,LiYuandMichaelJ.Lenardo,SpinsterisrequiredforautophagiclysosomereformationandmTORreactivationfollowingstarvation.PNAS,2011Apr25.[Epubaheadofprint].(LiYuascorrespondingauthor)

LiYu,ChristinaK.McPhee,LixinZheng,GonzaloA.Mardones,YueguangRong,JunyaPeng,NaMi,YingZhao,ZhihuaLiu,FengyiWan,DaleW.Hailey,ViolaOorschot,JudithKlumperman,EricH.Baehrecke,andMichaelJ.Lenardo,TerminationofautophagyandreformationoflysosomesregulatedbymTOR.Nature,2010Jun6.[Epubaheadofprint]

YeTian,ZhipengLi,WanqiuHu,HaiyanRen,ETian,YuZhao,QunLu,XinxinHuang,PeiguoYang,XinLi,XiaochenWang,AttilaL.Kovács,LiYu,andHongZhang.C.elegansScreenIdentifiesAutophagyGenesSpecifictoMulticellularOrganisms.Cell,2010Jun11;141(6):1042-1055(LiYuasco-correspondingauthor)

EricC.Freundt,LiYu,CynthiaS.Goldsmith,SarahWelsh,AaronCheng,BoydYount,WeiLiu,MatthewB.Frieman,UrsulaJ.Buchholz,GavinR.Screaton,JenniferLippincott-Schwartz,SherifR.Zaki,Xiao-NingXu,RalphS.Baric,KantaSubbarao,MichaelJ.Lenardo.SARS-CoVORF3aProteinPromotesMembraneRearrangementandCellDeath,JournalofVirology.2010Jan;84(2):1097-109(LiYuascorrespondingauthorandco-firstauthor)

YuL,AlvaA,SuH,DuttP,FreundtE,WelshS,BaehreckeEH,LenardoMJ.RegulationofanATG7-beclin1programofautophagiccelldeathbycaspase-8.Science.2004Jun4;304(5676):1500-2

YuL,FengyiWan,SudeshnaDutta,SarahWeish,ZhihuaLiu,EricFreundt,Erich.Baehrecke,andMichaelLenardo.Autophagicprogrammedcelldeathbyselectivecatalasedegradation.PNAS.March17,2006.

YuL,MindyCHebert,YingZhang.TGF-betareceptor-activatedp38MAPkinasemediatesSmad-independentTGF-betaresponse.EMBO.J2002Jul15;21(14):3749-59

YuL,StrandbergL,LenardoMJ.Theselectivityofautophagyanditsroleincelldeathandsurvival.Autophagy.2008Jul1;4(5):567-73

YuL,LenardoMJ.Immunology.Theparacaspaseconnection.Science.2003Nov28;302(5650):1515-6

联系方式:
电话：+86-10-62792880
E-mail:liyulab@mail.tsinghua.edu.cn