张淑平博士教授
1993-1998年，中国农业大学获得理学硕士和博士学位；
1998-2000年，清华大学博士后；
2001年，美国乔治亚大学访问学者/博士后；
2002年，美国耶鲁大学访问学者/博士后；
2000年至今，清华大学生命科学学院工作。

主要研究领域、研究方向：
利用哺乳动物细胞和小鼠模型开展激素相关的细胞信号转导机制的研究，特别是在两个方面：1.MGARP基因在早期胚胎发育中的作用及调控机理的研究；2.NOK/STYK1基因在肿瘤形成及转移过程中的作用及细胞信号网络的研究。
部分论文(^¶通信作者)：

ZhouM^#,LiangT^#,WangY,JinD,WangJ,JiaL,ZhangS(P)^¶.Expressionandtissuelocalizationofrenalase,anovelsolubleFAD-dependentprotein,inreproductive/steroidogenicsystems.MolBiolRep.2012Dec28.[Epubaheadofprint].(^#Equalcontribution)

JinD,LiR,MaoD,LuoN,WangY,ChenS,ZhangS(P)^¶.Mitochondria-localizedglutamicacid-richprotein(MGARP)genetranscriptionisregulatedbySp1.2012,PloSONE.2012,7(11)e50053

LiJ,WuF,ShengF,LiYJ,JinD,DingX,ZhangS(P)^¶.NOK/STYK1interactswithGSK-3βandmediatesSer9phosphorylationthroughactivatedAkt.FEBSletters.2012(586)3787–3792

DingX,JiangQB,LiR,ChenS,ZhangS(P)^¶.NOK/STYK1hasastrongtendencytowardsformingaggregatesandcolocaliseswithepidermalgrowthfactorreceptorinendosomes,BiochemBiophysResCommun.2012,421:468–473.

ZhouM^#,WangY^#,QiS,WangJ,ZhangS(P)^¶.Amitochondria-localizedglutamicacid-richproteinisinvolvedinHPGaxis.Endocrinology.2011,152(6):2311-20.(^#Equalcontribution)

QiS,WangY,ZhouM,GeY,YanY,WangJ,ZhangSS,ZhangS(P)^¶.Amitochondria-localizedglutamicacid-richprotein(MGARP/OSAP)ishighlyexpressedinretinathatexhibitsalargeareaofintrinsicdisorder.MolBiolRep.2011,38:2869-2877.

WangJ，QiSL,ChengW,LiL,WangF,LiYZ,ZhangS(P)^¶.Identification,expressionandtissuedistributionofarenalasehomologuefrommouse,MolBiolRep.2008,35:613-20.

ZhangS(P)^¶.Aresearch-project-basedandself-determinedteachingsystemofmolecularbiologytechniquesforundergraduates,BMBE,2008,36(3):181-8.

LiYH,ZhongS,RongZL,RenYM,LiZY,ZhangS(P),ChangZ,LiuL^¶.Thecarboxylterminaltyrosine417residueofNOKhasanautoinhibitoryeffectonNOK-mediatedsignalingtransductions.BiochemBiophysResCommun.2007,356(2):444-9.

ChenY,LiYH,ChenXP,GongLM,ZhangS(P),ChangZJ,ZhangXF,FuXY,LiuL^¶.PointmutationatsingletyrosineresidueofnoveloncogeneNOKabrogatestumorigenesisinnudemice.CancerRes.2005,65(23):10838-46.

LiYH,WangYY,ZhongS,RongZL,RenYM,LiZY,ZhangS(P),ChangZJ,LiuL^¶.Transmembranehelixofnoveloncogenewithkinase-domain(NOK)influencesitsoligomerizationandlimitstheactivationofRAS/MAPKsignaling.MolCells.2009,27(1):39-45.

ZhangY,LiT,FuL,YuC,LiY,XuX,WangY,NingH,ZhangS,ChenW,BabiukLA,ChangZ^¶.SilencingSARS-CoVSpikeproteinexpressioninculturedcellsbyRNAinterference，BiochemBiophysResCommun.2004,26;324(4):1186-93.

LiuL,YuXZ,LiTS,SongLX,ChenPL,SuoTL,LiYH,WangSD,ChenY,RenYM,ZhangS(P),ChangZJ,FuXY^¶.AnovelproteintyrosinekinaseNOKthatshareshomologywithplatelet-derivedgrowthfactor/fibroblastgrowthfactorreceptorsinducestumorigenesisandmetastasisinnudemice.CancerRes.2004,64(10):3491-9.

LiL,XinH,XuX,HuangM,ZhangX,ChenY,ZhangS(P),FuXY,ChangZ^¶.CHIPMediatesDegradationofSmadProteinsandPotentiallyRegulatesSmad-InducedTranscription.MolCellBiol.2004,24(2):856-864.

XiongS,ZhaoQ,RongZ,HuangG,HuangY,ChenP,ZhangS(P),LiuL,ChangZ^¶.hSefinhibitsPC12celldifferentiationbyinterferingwithRas-MAPKsignaling,JBiolChem.2003,278:50273-50282.

联系方式:
电话：+86-10-62773628(O);+86-010-62795470(L)
E-mail：bczhang@mail.tsinghua.edu.cn/shpzhang@biomed.tsinghua.edu.cn