Author(s): Yu, JH (Yu, Jiahuan); Xu, MK (Xu, Mengke); Liang, LY (Liang, Lingyan); Guan, M (Guan, Min); Zhang, Y (Zhang, Yang); Yan, F (Yan, Feng); Cao, HT (Cao, Hongtao)
Source: APPLIED PHYSICS LETTERS Volume: 116 Issue: 12 Article Number: 123704 DOI: 10.1063/5.0001786 Published: MAR 23 2020
Abstract: Separative extended-gate AlGaAs/GaAs high electron mobility transistor (HEMT) biosensors based on the capacitance change strategy are proposed and fabricated. The working mechanism underlying this strategy is clearly clarified via examining the capacitance evolution on biorecognition and the capacitance matching issue between the HEMT and the sensing pad. The fabricated biosensors demonstrate a good linear current/voltage response to a label-free prostate-specific antigen (PSA) target over a broad concentration range of 100 fg/ml to 10ng/ml in both 0.1x and 1x phosphate buffered saline solutions. Specifically, the sensitivity variation approaches 8.7% dec(-1) at the critical concentration level of 2-8ng/ml that enters the normal PSA region in the human body. The advantages of high sensitivity, low-cost, and convenience of usage make the proposed HEMT biosensors potential candidates for prostate cancer diagnosis.
Accession Number: WOS:000522036800001
Author Identifiers:
AuthorWeb of Science ResearcherIDORCID Number
Liang, Lingyan O-8614-2014 0000-0002-6285-6600
ISSN: 0003-6951
eISSN: 1077-3118
Full Text: https://aip.scitation.org/doi/10.1063/5.0001786