Author(s): Xu, AL (Xu, Anli); He, P (He, Peng); Ye, CC (Ye, Caichao); Liu, ZD (Liu, Zhiduo); Gu, BL (Gu, Bingli); Gao, B (Gao, Bo); Li, YQ (Li, Yongqiang); Dong, H (Dong, Hui); Chen, D (Chen, Da); Wang, G (Wang, Gang); Yang, SW (Yang, Siwei); Ding, GQ (Ding, Guqiao)
Source: ACS APPLIED MATERIALS & INTERFACES Volume: 12 Issue: 9 Pages: 10781-10790 DOI: 10.1021/acsami.9b20434 Published: MAR 4 2020
Abstract: The evaluation of intracellular reactive oxygen species (ROS) would greatly deepen the understanding of cell metabolism/proliferation and tumor detection. However, current long-acting level tracking techniques for intracellular ROS remain unsuited to practical applications. To solve this problem, we synthesized cyclotriphosphazene-doped graphene quantum dots (C-GQDs) whose quantum yield is highly sensitive to ROS (increased by 400% from 0.12 to 0.63). Electron cloud polarization of oxidized cyclotriphosphazene rings in C-GQDs is confirmed to account for this novel optical property by density functional theory calculations and experimental results. In combination with excellent biological stability, C-GQDs achieve a long-acting evaluation of intracellular ROS level (more than 72 h) with an accuracy of 98.3%. In addition, recognition rates exceeding 90% are demonstrated to be feasible for eight kinds of tumor cell lines cultured with C-CTC detection GQDs, which can also be expanded to in vivo detection. C-GQDs also show a high recognition rate (82.33%) and sensitivity (79.65%) for tumor cells in blood samples.
Accession Number: WOS:000518702300074
PubMed ID: 32048821
Author Identifiers:
AuthorWeb of Science ResearcherIDORCID Number
Ye, Caichao D-2739-2011 0000-0002-9197-8922
ISSN: 1944-8244
eISSN: 1944-8252
Full Text: https://pubs.acs.org/doi/10.1021/acsami.9b20434