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Longitudinal study of BK Polyomavirus outcomes, risk factors, and kinetics in renal transplantation patients
文献类型：期刊
期刊名称：Microbial pathogenesis影响因子和分区
年：2020
卷：142
页码：104036
ISSN：1096-1208
关键词：BK virus,BK virus associated nephropathy,Intravenous immunoglobulin,Kinetics,Risk factors
所属部门：统计学院
摘要：In the immunocompromised conditions following renal transplantation, BK virus can reactivate and cause BK virus associated nephropathy (BKVN). Increased BK viral loads and extended duration of infection have been linked to development of BKVN. The aim of this study was to observe the incidence of BKV infection and BKVN, and kinetics of infection and disease in renal transplantation recipients.From 2014 to 2018, we conducted a longitudinal cohort observational study of 139 renal transplantation p ...More
In the immunocompromised conditions following renal transplantation, BK virus can reactivate and cause BK virus associated nephropathy (BKVN). Increased BK viral loads and extended duration of infection have been linked to development of BKVN. The aim of this study was to observe the incidence of BKV infection and BKVN, and kinetics of infection and disease in renal transplantation recipients.From 2014 to 2018, we conducted a longitudinal cohort observational study of 139 renal transplantation patients treated at a single clinic. Quantitative PCR assay was conducted to assess longitudinal BK viral loads. Analysis of patient clinical characteristics was performed to determine risk factors for BKV infection and associated disease.Of our cohort, 29 (20.9%) patients developed high BK viremia, and 7 (5.0%) developed biopsy-confirmed BKVN. Clinical parameters associated with diabetes (FBS, HbA1c) and hyperlipidemia (TG, TC, LDL-C) were found to be correlated with development of high BK viremia or BKVN. In 3 of 4 patients receiving intravenous immunoglobulin (IVIG) treatment, BK viral loads were reduced by at least 1 log within 2-3 months of administration. Significant differences were measured in BK viral loads and kidney function between BK viremic patients and BKVN patients by 3-9 months post-transplantation.We identified diabetes and hyperlipidemia as potential risk factors for development of high BK viremia and/or BKVN. IVIG was seen to be effective in reducing viral titers. The period 3-9 months post-transplantation was identified as important for development of BKVN from high BK viremia.Copyright ? 2020 Elsevier Ltd. All rights reserved. ...Hide

DOI：10.1016/j.micpath.2020.104036
百度学术：Longitudinal study of BK Polyomavirus outcomes, risk factors, and kinetics in renal transplantation patients
语言：外文
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