文献详情
RhB-encapsulating silica nanoparticles modified with PEG impact the vascular endothelial function in endothelial cells and zebrafish model
文献类型：期刊
通讯作者：Duan, JC; Sun, ZW (reprint author), Capital Med Univ, Sch Publ Hlth, Dept Toxicol & Sanit Chem, Beijing 100069, Peoples R China.; Duan, JC; Sun, ZW (reprint author), Capital Med Univ, Beijing Key Lab Environm Toxicol, Beijing 100069, Peoples R China.; Wang, YP (reprint author), Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China.
期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT影响因子和分区
年：2020
卷：711
ISSN：0048-9697
关键词：RhB-encapsulating SiNPs; PEG modification; Vascular function; Zebrafish; Endothelial cells
所属部门：化学系
摘要：Silica nanoparticles (SiNPs) have been widely used in human health related products, such as food additives, cosmetics and even drug delivery, gene therapy or bioimaging. Recently, a first-in-human clinical trial based on polyethylene glycol (PEG)-modified SiNPs had been approved by US FDA to trace melanoma. However, as a nano-based drug delivery system, its biocompatibility and vascular toxicity are still largely unknown. Thus, we synthesized the fluorescent SiNPs to explore the biocompatibilit ...More
Silica nanoparticles (SiNPs) have been widely used in human health related products, such as food additives, cosmetics and even drug delivery, gene therapy or bioimaging. Recently, a first-in-human clinical trial based on polyethylene glycol (PEG)-modified SiNPs had been approved by US FDA to trace melanoma. However, as a nano-based drug delivery system, its biocompatibility and vascular toxicity are still largely unknown. Thus, we synthesized the fluorescent SiNPs to explore the biocompatibility and vascular endothelial function, and compare different biological effects caused by PEG-modified and unmodified SiNPs in cells and zebrafish model. The characterizations of SiNPs and PEG-modified SiNPs were analyzed by TEM, SEM, AFM and DLS, which exhibited relatively good stable and dispersive. Compared with SiNPs, PEG-modified SiNPs had markedly reduced the inflammatory response and vascular damage in Tg (fli-1: EGFP) and Tg (mpo: GFP) transgenic zebrafish lines, respectively. Consistent with the in vivo results, the PEG-modified SiNPs had been found to significantly decline the levels of ROS, inflammatory cytokines and mitochondrial-mediated apoptosis in vascular endothelial cells compared to SiNPs, and the ROS scavenger NAC could effectively alleviate the above adverse effects induced by nanoparticles. Our results suggested that the PEG-modified SiNPs could become more safety via increasing the biocompatibility and decreasing cellular toxicities in living organisms. (C) 2019 Elsevier B.V. All rights reserved. ...Hide

DOI：10.1016/j.scitotenv.2019.134403
百度学术：RhB-encapsulating silica nanoparticles modified with PEG impact the vascular endothelial function in endothelial cells and zebrafish model
语言：外文
基金：National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81773462, 81973077, 81930091]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7172027]; Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety, CASUnited States Department of Health & Human ServicesCenters for Disease Control & Prevention - USA [NSKF201817]
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