文献详情
Acute oral methylmercury exposure perturbs the gut microbiome and alters gut-brain axis related metabolites in rats
文献类型：期刊
通讯作者：Li, YF (reprint author), Chinese Acad Sci, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China.; Chang, DH (reprint author), Renmin Univ China, Sch Environm & Nat Resources, Beijing 100872, Peoples R China.
期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY影响因子和分区
年：2020
卷：190
ISSN：0147-6513
关键词：Methylmercury; Gut microbiome; Metabolites; Gut-brain axis; Neurotoxicity
所属部门：环境学院
摘要：Environmental pollutants like methylmercury (MeHg) can bring devastating neurotoxicity to animals and human beings. Gut microbiota has been found to demethylate MeHg and promote the excretion of Hg through feces. However, the impacts of MeHg on gut microbiota and metabolites related to gut-brain interactions were less studied in mammals. The object of this study was to investigate the impacts of acute MeHg exposure on gut microbiome and metabolites together with its impact on gut integrity and r ...More
Environmental pollutants like methylmercury (MeHg) can bring devastating neurotoxicity to animals and human beings. Gut microbiota has been found to demethylate MeHg and promote the excretion of Hg through feces. However, the impacts of MeHg on gut microbiota and metabolites related to gut-brain interactions were less studied in mammals. The object of this study was to investigate the impacts of acute MeHg exposure on gut microbiome and metabolites together with its impact on gut integrity and related biological responses in rats. Rats were exposed to MeHg through oral administration and were sacrificed after 24 h 16 S rRNA gene sequencing was used to study the perturbance to gut microbiome and liquid chromatography mass spectrometry (LC-MS) was used for metabolomics profiling. It was found that gut was one of the target tissues of MeHg. MeHg induce the changes of intestinal microbial community structure and induce the regulating neuron activity change of intestinal neurotransmitters and metabolites on intestinal neurotransmitters and metabolites regulating the neuron activity. This was supported by the increased BDNF level. These findings may suggest a potential new mechanism regarding the neurotoxicity of MeHg. The protocols used in this study may also be applied to understand the neurotoxicity of other environmental neurotoxins like Pb, Mn, polychlorinated biphenyls, and pesticides, etc and to screen the neurotoxicity of emerging environmental contaminants. ...Hide

DOI：10.1016/j.ecoenv.2019.110130
百度学术：Acute oral methylmercury exposure perturbs the gut microbiome and alters gut-brain axis related metabolites in rats
语言：外文
基金：National Natural Science Foundation of ChinaNational Natural Science Foundation of China [11975247, 11475196]; Ministry of Science and Technology of ChinaMinistry of Science and Technology, China [2016YFA0201600]; Guizhou Department of Science and Technology, China [QKH-2016-2804]
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