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Copper(II) Coordination and Translocation in Luteolin and Effect on Radical Scavenging

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Copper(II) Coordination and Translocation in Luteolin and Effect on Radical Scavenging
文献类型:期刊
通讯作者:Han, RM (reprint author), Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China.; Skibsted, LH (reprint author), Univ Copenhagen, Dept Food Sci, Rolighedsvej 30, DK-1958 Frederiksberg, Denmark.
期刊名称:JOURNAL OF PHYSICAL CHEMISTRY B影响因子和分区
年:2020
卷:124
期:2
页码:380-388
ISSN:1520-6106
所属部门:化学系
摘要:Luteolin differs as a radical scavenger dramatically from apigenin in response to Cu(II) coordination despite a minor structural difference. Coordination of Cu(II) increases the radical scavenging efficiency of luteolin, especially at low pH, while decreases the efficiency of apigenin at both low and higher pH as studied by ABTS(center dot+) radical scavenging. Luteolin forms a 1:1 complex with Cu(II) binding to 4-carbonyl and 5-phenol for pH <6 and to 3',4'-catechol for pH >6. Apigenin forms a ...More
Luteolin differs as a radical scavenger dramatically from apigenin in response to Cu(II) coordination despite a minor structural difference. Coordination of Cu(II) increases the radical scavenging efficiency of luteolin, especially at low pH, while decreases the efficiency of apigenin at both low and higher pH as studied by ABTS(center dot+) radical scavenging. Luteolin forms a 1:1 complex with Cu(II) binding to 4-carbonyl and 5-phenol for pH <6 and to 3',4'-catechol for pH >6. Apigenin forms a 1:2 complex independent of pH coordinated to 4-carbonyl and 5-hydroxylyl. Cu(II) coordinated to luteolin, as studied by pH jump stopped-flow, translocates with rate constants of 11.1 +/- 0.3 s(-1) from 4,5 to 3',4' sites and 1.0 +/- 0.1 s(-1) from 3',4' to 4,5 sites independent of Cu(II) concentration, pointing toward the dissociation of Cu(II) from an intermediate with two Cu(II) coordination as rate determining. 3',4'-Catechol is suggested to be a switch for Cu(II) translocation with deprotonation initiating 4,5 to 3',4' translocation and protonation initiating 3',4' to 4,5 translocation. For dicoordinated apigenin, the coordination symmetry balances an electron withdrawal effect of Cu(II) resulting in a decrease of phenol acidity and less radical scavenging efficiency compared to parent apigenin. Compared to that of parent luteolin, the radical scavenging rate of both 4,5 and 3',4' Cu(II)-coordinated luteolin is enhanced through increased phenol acidity by electron withdrawal by Cu(II), as confirmed by density functional theory (DFT) calculations. Coordination and translocation of Cu(II) accordingly increases the antioxidant activity of luteolin at pH approaching the physiological level and is discovered as a novel class of natural molecular machinery derived from plant polyphenols, which seems to be of importance for protection against oxidative stress. ...Hide

DOI:10.1021/acs.jpcb.9b10531
百度学术:Copper(II) Coordination and Translocation in Luteolin and Effect on Radical Scavenging
语言:外文
人气指数:2
浏览次数:2
基金:Natural Science Foundation of ChinaNational Natural Science Foundation of China [21573284, 21673288]
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