文献详情
A cobalt corrole/carbon nanotube enables simultaneous electrochemical monitoring of oxygen and ascorbic acid in the rat brain
文献类型：期刊
通讯作者：Zhang, MN (reprint author), Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China.
期刊名称：ANALYST影响因子和分区
年：2020
卷：145
期：1
页码：70-75
ISSN：0003-2654
所属部门：化学系
摘要：It is of interest to in vivo monitor the co-dynamics of different substances. However, the tracking of multiple species is still challenging. In this work, we demonstrate an in vivo electrochemical method by using multi-potential step amperometry to in vivo detect ascorbic acid (AA) and oxygen (O-2) simultaneously. In order to achieve good selectivity and high sensitivity for both AA and O-2, we design a cobalt corrole [Co(tpfc)(py)(2)] (tpfc = 5,10,15-tris(penta-fluorophenyl) corrole, py = pyri ...More
It is of interest to in vivo monitor the co-dynamics of different substances. However, the tracking of multiple species is still challenging. In this work, we demonstrate an in vivo electrochemical method by using multi-potential step amperometry to in vivo detect ascorbic acid (AA) and oxygen (O-2) simultaneously. In order to achieve good selectivity and high sensitivity for both AA and O-2, we design a cobalt corrole [Co(tpfc)(py)(2)] (tpfc = 5,10,15-tris(penta-fluorophenyl) corrole, py = pyridine, denoted as Co-TPFC) and carbon nanotube nanocomposite to modify a carbon fiber microelectrode (Co-TPFC/MWNT/CFE). This Co-TPFC/MWNT/CFE exhibits excellent electrocatalytic properties towards the reduction of O-2 preceding a 4e process and facilitates the oxidation of AA at low potential in the physiological environment. Based on this, we realize simultaneous detection of AA and O-2 using two-potential steps (one cathodic (-0.2 V) and the other anodic (+0.05 V)) with 1 second step time. Both in vitro and in vivo experiments proved the feasibility of this method. This demonstrated strategy is useful for us to understand various physiological and pathological processes associated with O-2 and AA co-dynamics, and also provides an idea for detecting multiple substances simultaneously. ...Hide

DOI：10.1039/c9an01946d
百度学术：A cobalt corrole/carbon nanotube enables simultaneous electrochemical monitoring of oxygen and ascorbic acid in the rat brain
语言：外文
人气指数：1
浏览次数：1
基金：National Natural Science Foundation of ChinaNational Natural Science Foundation of China [21874152]
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