文献详情
Naturally occurring nanotube with surface modification as biocompatible, target-specific nanocarrier for cancer phototherapy
文献类型：期刊
期刊名称：Biomaterials影响因子和分区
年：2019
卷：190-191
页码：86-96
ISSN：1878-5905
关键词：Cell membrane,Giant unilamellar vesicle,Halloysite nanotubes,Phototherapy,Pickering effect
所属部门：化学系
摘要：Phototherapy has drawn increasing attention including the use of nanocarriers with high drug loading capacity and delivery efficacy for target-specific therapy. We have made use of naturally-occurring halloysite nanotubes (HNTs) to build a biomimetic nanocarrier platform for target-specific delivery of phototherapeutic agents. The HNTs were decorated with poly(sodium-p-styrenesulfonate) (PSS) to enhance the biocompatibility, and were further functionalized by lumen loading the type-II photosensi ...More
Phototherapy has drawn increasing attention including the use of nanocarriers with high drug loading capacity and delivery efficacy for target-specific therapy. We have made use of naturally-occurring halloysite nanotubes (HNTs) to build a biomimetic nanocarrier platform for target-specific delivery of phototherapeutic agents. The HNTs were decorated with poly(sodium-p-styrenesulfonate) (PSS) to enhance the biocompatibility, and were further functionalized by lumen loading the type-II photosensitizer indocyanine green (ICG). The HNT-PSS-ICG nanocarrier, without further tethering targeting groups, was shown to associate with the membrane of giant unilamellar vesicles (GUVs) via Pickering effects. Application of HNT-PSS-ICG nanocarrier to human breast cancer cells gave rise to a cell mortality as high as 95%. The HNT-PSS-ICG nanocarrier was further coated with MDA-MB-436?cell membranes to endow it with targeting therapy performance against breast cancer, which was confirmed by in vivo experiments using breast cancer tumors in mice. The membrane-coated and biocompatible nanocarrier preferentially concentrated in the tumor tissue, and efficiently decreased the tumor volume by a combination of photodynamic and photothermal effects upon near-infrared light exposure. Our results demonstrate that the HNT-based nanocarrier by virtue of facial preparation and high loading capacity can be a promising candidate for membrane-targeting nanocarriers.Copyright ? 2018 Elsevier Ltd. All rights reserved. ...Hide

DOI：10.1016/j.biomaterials.2018.10.046
百度学术：Naturally occurring nanotube with surface modification as biocompatible, target-specific nanocarrier for cancer phototherapy
语言：外文
人气指数：6
浏览次数：6
作者其他论文



Naturally occurring nanotube with surface modification as biocompatible, target-specific nanocarrier for cancer phototherapy.Li Luo-Yuan, Zhou Yi-Ming, Gao Rong-Yao, et al. .Biomaterials. 2018, 190-191, 86-96.
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