文献详情
Mathematical modeling in scheduling cancer treatment with combination of VEGF inhibitor and chemotherapy drugs
文献类型：期刊
期刊名称：Journal of theoretical biology影响因子和分区
年：2019
卷：462
页码：490-498
ISSN：1095-8541
关键词：Anti-VEGF,Chemotherapy,Combination therapy,Mathematical model,Scheduling
所属部门：数学科学研究院
摘要：The present paper considers a treatment of cancer with a combination of anti-VEGF (bevacizumab) and a chemotherapy drug (docetaxel). Since anti-VEGF reduces the perfusion of chemotherapy drugs, the question arises whether it is more effective to administer the two drugs at the same time, or non-overlapping, in order to reduce tumor volume more effectively. To address this question we develop a mathematical model and use it to simulate different schedules. We find that the treatment of cancer wou ...More
The present paper considers a treatment of cancer with a combination of anti-VEGF (bevacizumab) and a chemotherapy drug (docetaxel). Since anti-VEGF reduces the perfusion of chemotherapy drugs, the question arises whether it is more effective to administer the two drugs at the same time, or non-overlapping, in order to reduce tumor volume more effectively. To address this question we develop a mathematical model and use it to simulate different schedules. We find that the treatment of cancer would be far more effective if the two drugs are given non-overlappingly, with the chemotherapy drug at day 0 and anti-VEGF at day 7 in cycles of 21 days.Copyright ? 2018 Elsevier Ltd. All rights reserved. ...Hide

DOI：10.1016/j.jtbi.2018.11.018
百度学术：Mathematical modeling in scheduling cancer treatment with combination of VEGF inhibitor and chemotherapy drugs
语言：外文
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A stochastic model that explains axonal organelle pileups induced by a reduction of molecular motors.Lai Xiulan, Brown Anthony, Xue Chuan,.Journal of the Royal Society, Interface. 2018, 15(148).
Mathematical modeling in scheduling cancer treatment with combination of VEGF inhibitor and chemotherapy drugs.Lai Xiulan, Friedman Avner,.Journal of theoretical biology. 2018.
Mathematical modeling in scheduling cancer treatment with combination of VEGF inhibitor and chemotherapy drugs.Lai Xiulan, Friedman Avner,.Journal of theoretical biology. 2018, 462, 490-498.
How to schedule VEGF and PD-1 inhibitors in combination cancer therapy?.Lai Xiulan, Friedman Avner,.BMC systems biology. 2019, 13(1), 30.