杜为红副教授

专业：物理化学电话：010-62512660，传真：010-62516444电子邮件：whdu@chem.ruc.edu.cn教育背景：1986.9-1990.7,山西大学化学系,本科1990.9-1993.7,山西大学分子科学研究所,硕士1997.9-2000.7,北京大学化学与分子工程学院,博士工作经历：1993.7-1997.8,山西大学化学系，教师2000.9-2001.3,香港大学化学系，博士后2001.4-2003.4,美国加州大学戴维斯分校化学系，博士后2003.8-2005.5,北京师范大学化学系,教师2005.6-,中国人民大学化学系，教师　教授课程：物理化学（本科）；生物物理化学（研究生）　主要研究方向：生物物理与生物无机化学主要研究内容：生物大分子与配体相互作用的光谱学、波谱学研究2.生物毒素的结构与功能关系3.生物大分子与小分子相互作用的热动力学主要科研项目与课题：中国人民大学引进人才资助项目50万元国家自然科学基金面上项目26万元教育部科学技术重点项目10万元973计划子课题20万元　主要发表论文：1.JiaXu,GoweiYin,WeihongDu^*.Distalmutationmodulatesthehemeslidinginmouseneuroglobininvestigatedbymoleculardynamicssimulation.Proteins.Struc.Func.Bioinfo.2011,79,191-202.2.YanliWang,JiaXu,LuWang,BingbingZhang,WeihongDu^*.InteractionofthehumanprionproteinPrP106-126withmetalcomplexes:potentialtherapeuticagentsagainstpriondisease.Chemistry,Eur.J.2010,16,13339-42.3.YanliWang,TongZhang^*,JiaXu,WeihongDu^*.Comparisonofthebindingaffinityofchlorogenicacidwithtwoserumalbumins.Int.J.Biol.Macromol.2010,inpress.4.JiaXu,YanliWang,BinbinZhang,BaohuaiWang,WeihongDu^*.Stereochemistryof4-hydroxyprolineaffectstheconformationofconopeptides.Chem.Commun.2010,46,5467-5469.5.JiaXu,GuoweiYin,FeijuanHuang,BaohuaiWang,WeihongDu^*.Moleculardynamicssimulationofacarboxymurineneuroglobinmutatedontheproximalside:hemedisplacementandconcomitantrearrangementinloopregionsJ.Mol.Model.2010,16,759-770.6.BinGao,JiaXu,MariadelCarmenRodrigues,HumbertoLanz-Mendoza,RosauraHernondez-Rivas,WeihongDu^*,ShunyiZhu^*.Characterizationoftwolinearcationicantimalarialpeptidesinthescorpionmesobuthuseupeus.Biochimie2010,92,350-359.7.JiaXu,LianzhiLi,GuoweiYin,HailiLi,WeihongDu^*.LigandorientationofhumanneuroglobinobtainedfromsolutionNMRandmoleculardynamicssimulationascomparedwithX-raycrystallography.J.Inorg.Biochem.2009,103,1693-1701.8.FeijuanHuang,WeihongDu^*,SolutionStructureofHyp10Provariantofconomarphin,acysteine-freeandD-amino-acidcontainingconopeptide.Toxicon,2009,54,153-160.9.YuhongHan,FeijuanHuang,HuiJiang,LiLiu,QiWang,YanfangWang,XiaoxiaShao,ChengwuChi,WeihongDu^*andChunguangWang^*,PurificationandstructuralcharacterizationofaD-aminoacidcontainingconopeptide,conomarphin,fromconusmarmoreus.FEBSJ.2008,275,1976-1987.10.GuoweiYin,YanjieLi,JuanLi,JingLi,WeihongDu*,QunWei^*,WeihaiFang.SolutionH-1NMRstudyoftheactivesitestructureforthedoublemutantH64Q/V68Fcyanidecomplexfrommouseneuroglobin.Biophys.Chem.2008,136,115-123.11.WeihongDu,YuhongHan,FeijuanHuang,JuanLi,ChengwuChi,WeihaiFang^*.SolutionstructureofanM-1Conotoxinmr3ewithanoveldisulfidelinkage.FEBSJ.2007,274,2596-2602.12.YimingLi,GuoweiYin,WeiWei,HengbinWang,ShanhaoJiang,DuyuanZhu^*,WeihongDu^*,InteractionsofLycopodiumalkaloidswithacetylcholinesteraseinvestigatedby¹HNMRrelaxationrate,Biophys.Chem.2007,129,212-217.13.WeihongDu,LingWang,BaohuaiWang,ZhifenLi,WeihaiFang^*.ActinoimycinDbindstosinglestrandedDNAoligomerswhichcontainsdoubleGTCtriplets.ThermochimicaActa2007,452,31-35.14.WeihongDu,RaySyvitski,SylviaDewilde,LucMoens,andGerdN.LaMar^*.Solution¹HNMRCharacterizationofEquilibriumHemeOrientationalDisorderwithFunctionalConsequenceinMouseNeuroglobin.J.Am.Chem.Soc.2003,125,8080-8081.15.WeihongDu,ZhichengXia,SylviaDewilde,LucMoens,GerdN.LaMar^*.¹HNMRstudyofthemolecularstructureandmagneticpropertiesoftheactivesiteforthecyanometcomplexofO₂-avidglobinfromtrametodeParaphistomumepiclitum.Eur.J.Biochem.2003,270,2707-2720.　



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