中文关键词内分泌干扰物无锡-常州地区地下水赋存特征健康风险 英文关键词endocrine disrupting chemicalsWuxi-Changzhougroundwateroccurrence characteristicshealth risk

作者	单位	E-mail
王淑婷	中国地质科学院国家地质实验测试中心, 自然资源部生态地球化学重点实验室, 北京 100037	shuting0429@163.com
饶竹	中国地质科学院国家地质实验测试中心, 自然资源部生态地球化学重点实验室, 北京 100037
郭峰	中国地质科学院国家地质实验测试中心, 自然资源部生态地球化学重点实验室, 北京 100037	fengguo@cags.ac.cn
刘成海	中国地质科学院国家地质实验测试中心, 自然资源部生态地球化学重点实验室, 北京 100037
战楠	中国地质科学院国家地质实验测试中心, 自然资源部生态地球化学重点实验室, 北京 100037
王娅南	中国地质科学院国家地质实验测试中心, 自然资源部生态地球化学重点实验室, 北京 100037 贵州医科大学公共卫生学院, 贵阳 550025
彭洁	中国地质科学院国家地质实验测试中心, 自然资源部生态地球化学重点实验室, 北京 100037 贵州医科大学公共卫生学院, 贵阳 550025
杨鸿波	贵州医科大学公共卫生学院, 贵阳 550025

中文摘要 采用固相萃取-超高效液相色谱串联质谱法（SPE-UPLC-MS/MS）分析了无锡-常州地区地下水中4类（性激素、孕激素、糖皮质激素和酚类激素）22种典型内分泌干扰物（EDCs）的赋存特征.结果表明，共有20种EDCs被检出，以双酚A（BPA）、雌酮（E1）、雌二醇（E2）和炔雌醇（EE2）为主，检出率均在90%以上，其次是雌三醇（E3）和甲基泼尼松龙（Meprednl），检出率分别为67.7%和48.4%.BPA平均浓度最高，为4.95 ng·L^-1，其次是甲基泼尼松龙、雌二醇、泼尼松龙（Prednl）、丙酸睾酮（TES-pro）和醋酸甲地孕酮（MA），平均浓度分别为2.84、0.71、0.64、0.58和0.53 ng·L^-1.各点位总浓度范围在0.38~147.35 ng·L^-1之间，高浓度点主要集中在常州市新北区、溧阳市和钟楼区.结合主成分分析（PCA）和采样点周边污染源对潜在来源进行解析，结果表明地下水中EDCs主要来源于生活污水、养殖和工业废水，其次为医疗废水.非致癌健康风险评价结果表明，研究区地下水中EDCs非致癌风险整体处于较低水平，饮水途径引起的风险水平大于皮肤暴露，EE2的非致癌风险最高，应作为重点监控对象. 英文摘要 The concentrations of 22 endocrine disrupting chemicals, including 4 categories of sex hormones, progesterones, glucocorticoids, and phenolic hormones, in groundwater of Wuxi-Changzhou were analyzed using solid-phase extraction and ultra-performance liquid chromatography tandem mass spectrometry. The results indicated that 20 EDCs were detected, among which bisphenol A (BPA), estrone (E1), estradiol (E2), and 17α-ethinyl estradiol (EE2) were the main components with detection ratios greater than 90%, followed by estriol (E3) and methyl-prednisolonel (Meprednl), which had detection rates 67.7% and 48.4%, respectively. The average concentration of BPA was the highest (4.95 ng·L^-1), followed by that of Meprednl, E2, prednisolone (Prednl), testosterone propionate (TES-pro), and megestrol-acetate (MA; 2.84, 0.71, 0.64, 0.58, and 0.53 ng·L^-1, respectively). The total concentration in each site ranged from 0.38 to 147.35 ng·L^-1. The sites with higher concentration were mainly distributed in the Xinbei District, Liyang City, and the Zhonglou District of Changzhou City. The potential sources were analyzed by a principal component analysis (PCA) combining the point sources near sample sites. The results showed that domestic sewage, aquaculture, and industrial wastewater were the main sources, following by medical wastewater. A non-carcinogenic risk assessment showed a low risk of EDCs in the groundwater of the study area, and the risk of drinking water was greater than that of skin exposure. EE2 had the highest non-carcinogenic risk and is suggested to be monitored in priority.

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