中文关键词萘普生(NAP)氯化降解机制中间产物风险评价 英文关键词naproxen (NAP)chlorinationdegradation mechanismintermediate productrisk assessment

作者	单位	E-mail
樊鑫鑫	常州大学环境与安全工程学院, 常州 213164	clifffan1994@163.com
杜尔登	常州大学环境与安全工程学院, 常州 213164	duerdeng@cczu.edu.cn
李佳琦	常州大学环境与安全工程学院, 常州 213164
赵丽丽	常州大学环境与安全工程学院, 常州 213164
王聿琳	常州大学环境与安全工程学院, 常州 213164
彭明国	常州大学环境与安全工程学院, 常州 213164

中文摘要 药用活性化合物（PhACs）在氯消毒过程中生成消毒副产物的问题引起了广泛关注.以典型PhACs物质萘普生（NAP）为研究对象，考察各因素对游离氯与NAP反应的影响，探究NAP氯化机制并进行风险评估.结果表明，NAP氯化反应遵循一级反应动力学，NAP在氯化过程中的降解率和反应速率常数随着NAP初始浓度和氨根离子投加量的增加而降低，随着游离氯初始浓度的增加而增大，酸性条件下更有利于NAP的氯化反应.基于HPLC-MS/MS分析鉴定出5种含氯降解中间产物，并提出氯化NAP反应机制.ESCOAR风险预测和发光菌毒性分析表明氯化NAP过程中生成了毒性更高的中间产物，对饮用水安全可能构成潜在威胁. 英文摘要 The by-products produced during chlorination of pharmaceutically active compounds (PhACs) have created widespread public concern. Chlorination of a typical PhAC, naproxen (NAP), was studied. NAP chlorination parameters, intermediates identification, chlorination mechanism, and risk assessment during chlorination process have also been discussed. The results showed that NAP chlorination could fit well with the fist-order kinetics. The rate of removal and rate constants of NAP chlorination decreased with increasing initial NAP concentration and ammonium dosage, while these values increased with increasing initial free chlorine concentration. Acidic condition of the solution could significantly promote NAP chlorination. Five intermediates were identified by HPLC-MS/MS, and the mechanism of NAP chlorination was also put forward. Vibrio fischeri toxicity analysis and ESCOAR prediction indicated that higher toxicity intermediates were produced during NAP chlorination, which pose a potential threat to drinking water safety.

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