廖文^1,2,3,
汪光^1,2,,,
李开明^1,2,
陈中颖^1,2
1. 生态环境部华南环境科学研究所, 国家环境保护水环境模拟与污染控制重点实验室, 广州 510655;
2. 广东省水与大气污染防治重点实验室, 广州 510655;
3. 中国科学院广州地球化学研究所, 广州 510640

作者简介: 廖文(1988-),女,博士,研究方向为环境毒理及健康风险评价,E-mail:liaowen0735@126.com.

通讯作者: 汪光,wangguang@scies.org ;

基金项目: 国家自然科学基金项目(21207046)；广东省自然科学基金项目(S2012010008396)；国家水体污染控制与治理科技重大专项(2015ZX07202-012)


中图分类号: X171.5

Bioaccessibility of Arsenic and Selenium in Food and Health Risk/Benefit Evaluation

Liao Wen^1,2,3,
Wang Guang^1,2,,,
Li Kaiming^1,2,
Chen Zhongying^1,2
1. National Key Laboratory of Water Environment Simulation and Pollution Control, South China Institute of Environmental Sciences, Ministry of Ecology and Environment, Guangzhou 510655, China;
2. Guangdong Key Laboratory of Water and Air Pollution Control, Guangzhou 510655, China;
3. Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China

Corresponding author: Wang Guang,wangguang@scies.org ;

CLC number: X171.5

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摘要:硒(Se)是人体必需的微量元素，一般通过大米和海鲜摄入。然而大米和海鲜是人体砷(As)暴露的主要途径之一。采用ICP-MS对广州市售的大米和3种鱼中砷和硒浓度进行了检测，并通过体外(in vitro)模拟胃肠消化(PBET)法对鱼肉中砷和硒的生物可给性进行了考察。结果表明，大米和鱼肉中砷的浓度分别为0.085～0.168 μg·g^-1和2.224～5.533 μg·g^-1，硒的浓度分别为0.098～0.190 μg·g^-1和1.641～2.315 μg·g^-1。大米和鱼肉中86.86%～99.34%和51.95%～75.64%的砷生物可给，76.73%～85.44%和71.48%~79.83%的硒生物可给。通过大米和鱼肉摄入的硒基本可以满足人体需求。通过大米和3种鱼摄入的无机砷占国际粮农组织和世界卫生组织(FAO/WHO)公布的无机砷的每日最高允许摄入量(TWI)2.1 μg·kg^-1 BW的0.5%～35.7%，但是摄入无机砷的致癌风险分别为1.69×10^-5～5.81×10^-4和2.13×10^-4～7.34×10^-4，是可接受或可容忍的风险的0.17～7.3倍，尤其是小孩，更易摄入砷产生毒害。
关键词: 砷/
硒/
大米/
海鲜/
生物可给性

Abstract:Selenium (Se) is an essential trace element for human beings. The common sources of Se are rice and seafood. However, they are one of the major pathways for exposure to arsenic (As). Se and As concentrations in three types of rice and three kinds of fishes, collected from markets in Guangzhou, China, were determined by ICP-MS. The bioaccessibility of the two elements were obtained by an in vitro physiologically-based extraction test (PBET). It showed that As contents of rice and fish were 0.085～0.168 μg·g^-1 and 2.224～5.533 μg·g^-1, respectively. Se levels in the two kinds of food were 0.098～0.190 μg·g^-1 and 1.641～2.315 μg·g^-1, respectively. The bioaccessibility of As in rice and fish were 86.86%～99.34% and 51.95%～75.64%, respectively. And 76.73%～85.44% and 71.48%～79.83% of Se in rice and fish were bioaccessible, respectively. In addition, the estimated daily intakes (EDI) of As and Se from food were calculated based on the bioaccessible concentrations. The calculated EDI of As accounted for 0.5%~35.7% of the total inorganic arsenic daily maximum allowable intake. However, the target cancer risk of the food was 0.17~7.3 times higher than the tolerable risk.
Key words:arsenic/
selenium/
rice/
seafood/
bioaccessibility.