杨巧云^1,2,
邱兴华^2,,,
李克秋³,
李光^3,,
1. 天津医科大学 公共卫生学院, 天津 300070;
2. 北京大学 环境科学与工程学院, 北京 100871;
3. 天津医科大学 基础医学院, 天津 300070

作者简介: 杨巧云(1986-),女,讲师,研究方向为污染物暴露与人群健康,E-mail:victoryyqy@sina.com.

通讯作者: 邱兴华,xhqiu@pku.edu.cn ; 李光,lig@tmu.edu.cn

基金项目: 国家自然基金(21322705,41421064,21190051)


中图分类号: X171.5

Exposure to Bisphenol A and the Oxidative Damage for Local Residents at an E-waste Dismantling Area

Yang Qiaoyun^1,2,
Qiu Xinghua^2,,,
Li Keqiu³,
Li Guang^3,,
1. School of Public Health, Tianjin Medical University, Tianjin 300070, China;
2. College of Environmental Sciences and Engineering, Peking University, Beijing 100871, China;
3. Basic Medical College, Tianjin Medical University, Tianjin 300070, China

Corresponding authors: Qiu Xinghua,xhqiu@pku.edu.cn ; Li Guang,lig@tmu.edu.cn

CLC number: X171.5

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摘要:中国已成为全球电子垃圾的主要回收地之一，电子垃圾拆解造成的污染物人体暴露及健康效应备受关注。尤其是在粗放的拆解方式下，释放的双酚A (bisphenol A，BPA)等污染物暴露以及对拆解地区人群的健康影响是重要的科学问题。选取中国北方某电子垃圾拆解地区(即暴露地区)人群为研究对象(包括29名电子垃圾拆解从业者和24名当地居民)，以40 km外无电子垃圾拆解地区的人群(N=53)作为参照。暴露地区人群尿液中BPA浓度(中值：10.7 μg·g^-1肌酐)显著高于参照地区人群(中值：0.66 μg·g^-1肌酐；P<0.01)，提示电子垃圾拆解活动可能造成当地人群对BPA的高暴露。暴露地区人群的尿液8-羟基脱氧鸟苷(8-OHdG；中值：236 μg·g^-1肌酐)高于参照人群(中值：142 μg·g^-1肌酐)，统计结果接近显著(P=0.055)。暴露地区人群血清中谷胱甘肽S转移酶(GSH-ST)与铜/锌-超氧化物歧化酶(Cu/Zn-SOD)含量较参照组显著降低；而谷胱甘肽过氧化物酶(GSH-Px)显著高于参照组(P<0.01)。BPA与8-OHdG显著正相关(P<0.05)、与GSH-ST负相关(P<0.01)；多元回归结果显示，尿液中BPA浓度每上升1倍，8-OHdG升高34.9%(95% CI：19.4%~52.3%)，而GSH-ST下降5.46%(95% CI：1.17%~9.56%)。本研究显示，电子垃圾拆解可导致该地区人群对BPA的高暴露，这种暴露可导致氧化应激包括对DNA的氧化损伤。
关键词: 双酚A/
氧化损伤/
8-羟基脱氧鸟苷/
抗氧化酶/
电子垃圾拆解/
健康风险

Abstract:China has become one of the major recycling sites for the electronic waste (e-waste) from worldwide. Pollutants emerged from the e-waste dismantling and the subsequent health effects to populations are of great concern. Typically, exposure to organic pollutants, such as bisphenol A (BPA) especially generated from primitive dismantling, is an important scientific issue for their adverse health effects to local residents. In this study, 29 e-waste dismantling workers and 24 local residents from a dismantling area in North China were recruited as the exposure group. Residents (N=53) living 40 km away from this e-waste area were selected as the reference. The median concentration of urinary BPA of the exposure group was 10.7 μg·g^-1 creatinine, which was significantly higher than that of the references (0.66 μg·g^-1 creatinine; P<0.01), indicating that working and/or living in the e-waste area caused the elevated body burden of BPA. Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) of the exposure group (median:236 μg·g^-1 creatinine) was higher than that of the references (median:142 μg·g^-1 creatinine) with a marginal significance (P=0.055). Meanwhile, serum levels of glutathione S-transferase (GSH-ST) and Cu/Zn-Superoxide dismutase (Cu/Zn-SOD) were significantly lower in the exposure group, while glutathione peroxidase (GSH-Px) was higher when compared to the references (P<0.01). Significantly positive association between urinary BPA and 8-OHdG was found (P<0.05); however, significantly negative association was found between BPA and serum GSH-ST (P<0.01). After controlling for confounders, 34.9% (95%CI:19.4%-52.3%) increment of urinary 8-OHdG and 5.46% (95%CI:1.17%-9.56%) decrement of serum GSH-ST per one-fold increase of BPA were estimated. Those results provided evidence on high exposure level of BPA among the populations from the e-waste dismantling area and a high risk of oxidative damage to DNA.
Key words:Bisphenol A/
oxidative damage/
8-hydroxy-2’-deoxyguanosine/
antioxidant enzyme/
electronic-waste dismantling/
health risk.