冀晓莹,
高美丽^,
生物科学工程实验室, 教育部生物信息工程重点实验室, 西安交通大学生命科学与技术学院, 西安 710049

作者简介: 冀晓莹(1991-),女,硕士在读,研究方向为环境毒理,Email:jxy13403542571@126.com.

通讯作者: 高美丽,gml.1369@mail.xjtu.edu.cn

基金项目: 陕西省自然科学基金(2014JQ4136)


中图分类号: X171.5

Research Progress in Neurotoxicity of Benzo(a)pyrene

Ji Xiaoying,
Gao Meili^,
Department of Biological Science and Engineering, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China

Corresponding author: Gao Meili,gml.1369@mail.xjtu.edu.cn

CLC number: X171.5

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摘要:苯并(a)芘(BaP)是一种广泛存在于环境中的多环芳烃,具有致癌、致畸、致突变性。目前BaP的神经毒性研究零散而不深入,本文主要总结分析了BaP的神经毒性表现,简要介绍了BaP诱发神经毒性呈现的剂量-效应关系,进一步系统阐述了目前研究中发现的可能分子机制,包括BaP诱导神经递质及其代谢物含量的改变,相关DNA及蛋白质的损伤,抗氧化系统及线粒体的改变等,以期为进一步研究提供参考。
关键词: 苯并(a)芘/
神经毒性/
剂量-效应关系

Abstract:Benzo(a)pyrene (BaP), widely existed in the environment. It has been proved to be carcinogenic, teratogenic, and mutagenic. However, studies of BaP neurotoxicity are not prevalent so far. In this paper, we summarized the neurotoxicity performance induced by BaP, briefly introduced the dose effect relationship, further elaborated the possible molecular mechanism founded in present study, including the change content of neurotransmitters' content and its metabolites induced by BaP, the damage to DNA and proteins, and the effect of antioxidant enzymes as well as the changes of mitochondria, to provide references for further research.
Key words:BaP/
neurotoxicity/
dose-effect relationship.