高强¹,
李昕²,
郝耀光²,
赵亦雯²,
周婧弘²,
尹希^3,,,
史海水^4,,
1. 河北医科大学 公共卫生学院营养与食品卫生学教研室, 石家庄 050017;
2. 河北医科大学 基础医学院, 石家庄 050017;
3. 河北医科大学第四医院功能科, 石家庄 050011;
4. 河北医科大学 基础医学院生化与分子生物学教研室, 石家庄 050017

作者简介: 高强(1982-),男,讲师,研究方向为食品营养与食品毒理学,E-mail:gaobuzhang@163.com.

通讯作者: 尹希,yinxixi2002@163.com ; 史海水,shihs@hebmu.edu.cn

基金项目: 国家自然科学基金(81201038,31371140)
河北省大学生创新创业资助课题(201410089042)
河北省科技厅科研基金(15275517)
河北省卫生与计生委科研基金(20150182,qn2015015)


中图分类号: X171.5

Effects of Exposure to Analogues of Bisphenol A on Depressive-like Behaviors in Mice

Gao Qiang¹,
Li Xin²,
Hao Yaoguang²,
Zhao Yiwen²,
Zhou Jinghong²,
Yin Xi^3,,,
Shi Haishui^4,,
1. Department of Nutrition and Food Hygiene, College of Public Health, Hebei Medical University, Shijiazhuang 050017, China;
2. College of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, China;
3. Department of Functional Region of Diagnosis, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China;
4. Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang 050017, China

Corresponding authors: Yin Xi,yinxixi2002@163.com ; Shi Haishui,shihs@hebmu.edu.cn

CLC number: X171.5

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摘要:作为重要的环境内分泌干扰物,双酚A的神经发育毒性已经引起广泛关注,其结构类似物对健康影响相关研究少有报道。为探讨双酚A结构类似物长期暴露对个体抑郁行为的影响,选取60只小鼠随机分为5组,每组12只。小鼠分别灌胃给予0、5、50 mg·kg^-1的双酚F或双酚S,连续给药4周。给药结束后,利用强迫游泳测试和悬尾测试评价小鼠抑郁样行为,同时监测小鼠体质量增加和自发活动情况。结果表明,与溶媒对照组比较,持续4周的双酚F和双酚S给药组小鼠的体质量变化和自发活动均无显著差异;5 mg·kg^-1的双酚F或双酚S处理均不显著改变小鼠的抑郁行为,50 mg·kg^-1双酚F显著增加小鼠悬尾和强迫游泳测试中的不动时间,50 mg·kg^-1双酚S处理显著增加小鼠悬尾测试中的不动时间。研究结果提示高浓度双酚F和双酚S在青春期的暴露可导致成年后小鼠抑郁样行为异常,应当引起重视。
关键词: 环境内分泌干扰物/
双酚F/
双酚S/
小鼠/
抑郁

Abstract:The adverse effects of bisphenol A (BPA) on neurodevelopment and behaviors have been well established. However, the effects of exposure to BPA analogues, bisphenol F (BPF) and bisphenol S (BPS), on depressive-like behaviors are poorly understood. In the present study, sixty mice were randomly divided into 5 groups and received by gavage 0, 5 or 50 mg·kg^-1 of BPF or BPS for 28 continuous days. Depressive-like behaviors were tested after BPF or BPS treatment by tail suspension test (TST) and forced swimming test (FST) mice paradigms. The bodyweight increased and locomotor activities of mice were also assessed. The results showed that BPF and BPS administration had no significant effects on both bodyweight change and locomotor activities. BPF or BPS treatment at 5 mg·kg^-1 dose had no significant effect on depressive-like behaviors. BPF treatment at 50 mg·kg^-1 significantly increased the immobility time in both FST and TST. BPS treatment at 50 mg·kg^-1 significant increased immobility time in TST, but just had an increased trend in FST. These findings indicated that chronic exposure to high BPF and BPS could affect the depressive-like behaviors in adult mice and should be paid more attention in the future.
Key words:environmental endocrine disruptor/
bisphenol F/
bisphenol S/
mouse/
depression.