高昆^1,2,
陈娟²,
李圆圆²,
刘春^1,,,
秦占芬²
1. 河北科技大学 环境科学与工程学院, 石家庄 050018;
2. 中国科学院生态环境研究中心 环境化学与生态毒理学国家重点实验室, 北京 100085

作者简介: 高昆(1990-),女,硕士,研究方向为环境毒理学,E-mail:15832139933@163.com.

通讯作者: 刘春,liuchun@hebust.edu.cn ;

基金项目: 国家自然科学基金项目(21377153)；中国科学院战略性先导科技专项(B类)(XDB14040102)


中图分类号: X171.5

Acute Toxicity of Triclosan and Triclocarban to Amphibian Tadpoles

Gao Kun^1,2,
Chen Juan²,
Li Yuanyuan²,
Liu Chun^1,,,
Qin Zhanfen²
1. College of Environmental Science and Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China;
2. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China

Corresponding author: Liu Chun,liuchun@hebust.edu.cn ;

CLC number: X171.5

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摘要:三氯生(TCS)和三氯卡班(TCC)是个人护理品中常用抗菌剂,在水体中普遍存在,但目前其对两栖动物的毒性研究仍较少。本研究以黑斑蛙蝌蚪和非洲爪蛙蝌蚪为受试生物,研究TCS和TCC对蝌蚪的急性毒性。将处于第一个蝌蚪发育期的黑斑蛙蝌蚪(Gosner 26期)和非洲爪蛙蝌蚪(NF 46期)分别暴露于系列浓度的TCS和TCC,测定其对蝌蚪的半数致死浓度(96 h-LC<sub>50/sub>)。结果发现,TCS对黑斑蛙蝌蚪和非洲爪蛙蝌蚪的96 h-LC50分别为441 μg·L^-1和280 μg·L^-1;TCC对黑斑蛙蝌蚪和非洲爪蛙蝌蚪的96 h-LC50为252 μg·L^-1和217 μg·L^-1。这些数据显示TCS和TCC对两种蝌蚪的毒性较高,且对非洲爪蛙蝌蚪毒性均略高于对黑斑蛙蝌蚪的毒性,整体来看TCC的毒性略高于TCS。
关键词: 三氯生/
三氯卡班/
黑斑蛙/
非洲爪蛙/
蝌蚪/
急性毒性

Abstract:Triclosan (TCS) and triclocarban (TCC) are broad-spectrum antimicrobial agents used in personal care products. They have become ubiquitous in aquatic environment due to its wide use. However, information concerning their toxicities to amphibians is limited. This study aimed to investigate acute toxicities of TCS and TCC to Pelophylax nigromaculatus tadpoles and Xenopus laevis tadpoles. P. nigromaculatus (Gosner stage 26) and X. laevis (NF stage 46) at the first tadpole developmental stage were exposed to series of concentrations of TCS and TCC. Median lethal concentrations (LC50) for 24 h, 48 h, 72 h and 96 h were calculated. We found that 96 h-LC50 for TCS to P. nigromaculatus tadpoles and X. laevis tadpoles were 441 μg·L^-1 and 280 μg·L^-1, respectively, while 96 h-LC50 for TCC to P. nigromaculatus tadpoles and X. laevis tadpoles were 252 μg·L^-1 and 217 μg·L^-1, respectively. The data show that TCS and TCC have relative high toxicity to P. nigromaculatus tadpoles and X. laevis tadpoles, with higher toxicity to the latter. The toxicity of TCC to tadpoles is slightly higher than that of TCS．
Key words:triclosan/
triclocarban/
Pelophylax nigromaculatus/
Xenopus laevis/
tadpoles/
acute toxicity.</sub>