张章¹,
唐天乐^1,2,
唐文浩^1,,
1. 海南大学环境与植物保护学院, 海口 570228;
2. 海南医学院热带医学与检验医学院, 海口 571199

作者简介: 张章(1989-),女,硕士研究生,研究方向为生态毒理学,Email:zzhang112233@126.com.

通讯作者: 唐文浩,twh1229@163.com

基金项目: 中西部高校提升综合实力工作资金资助项目(ZXBJH-XK004)；海南省科协青年科技人才学术创新计划项目(2015013)


中图分类号: X171.5

Research Progress in Ecotoxicological Effects of Engineered Nanomaterials on Zebrafish

Zhang Zhang¹,
Tang Tianle^1,2,
Tang Wenhao^1,,
1. College of Environment and Plant Protection, Hainan University, Haikou 570228, China;
2. School of Tropical and Laboratory Medicine, Hainan Medical University, Haikou 571199, China

Corresponding author: Tang Wenhao,twh1229@163.com

CLC number: X171.5

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摘要:随着纳米技术的快速发展，人工纳米材料在光电、生物医药、化妆品等诸多领域得到了广泛应用。人工纳米材料在生产、使用和废弃处理等过程中，不可避免地通过水体、土壤、大气等进入环境，其对环境产生的生态效应逐渐引起国内外的广泛关注。斑马鱼(Danio rerio)作为一种重要的脊椎模式生物，在环境毒理学研究中应用广泛，可以作为检测人工纳米材料生态毒理效应的一种重要工具。本文介绍了人工纳米材料对水生态环境的影响及斑马鱼在生态毒理学研究中的优势，总结了其对斑马鱼的毒性效应，主要包括急性毒性和对个体发育的影响、对组织细胞及基因表达的影响，分析了人工纳米材料对斑马鱼的毒性机制，以期为人工纳米材料毒理学研究提供基础信息。
关键词: 人工纳米材料/
斑马鱼/
毒理效应/
综述

Abstract:With the rapid development of nanotechnology, engineered nanomaterials (ENMs) have been widely used in photoelectricity, biological medicine, cosmetics, and many other fields. ENMs are inevitably discharged into the environment through water, soil and atmosphere during their production, use and disposal processes. The ecological effect of ENMs on the environment has gradually aroused wide attention both at home and abroad. Zebrafish (Danio rerio) as a model vertebrate has been commonly used in ecotoxicology, and it is also an important tool to test the ecotoxicological effects of ENMs. This paper introduces the effects of ENMs on aquatic environment and the advantage of zebrafish in ecotoxicology, then summarizes the toxic effects of ENMs on zebrafish, including acute toxicity and the impact on the individual development, histocyte and gene expression, and finally analyzes the toxicity mechanism of ENMs on zebrafish, which is aiming to provide basic information to ENMs toxicology research.
Key words:engineered nanomaterials/
zebrafish/
toxic effects/
review.