姓名： 胡立刚 性别： 男

职称： 研究员 学历： 博士

电话： 传真：

Email： lghu@rcees.ac.cn 邮编： 10085

地址： 北京海淀区双清路18号


简历：
1997年毕业于北京科技大学，2006年在中科院生态环境研究中心获博士学位。2006年至2009年在美国佛罗里达国际大学，2010年至2014年在香港大学分别从事博士后研究工作。
近几年主要从事金属的环境健康效应和环境地球化学循环研究。研究内容包括：1）金属组学方法学研究及相应仪器平台开发；2）金属污染物健康效应机制研究；3）细菌介导的金属形态转化和超累积研究。率先建立了凝胶电泳-电感耦合等离子体质谱在线金属蛋白质全局分析等方法并设计研制了相关仪器平台，研究了重金属蛋白质结合谱的特征及健康风险机制，研究了金属在细菌内的超累积行为及机制。相关研究工作发表在国际权威性研究杂志，如PNAS、Angew. Chem. Int. Ed.、Chem. Sci.和Environ. Sci. Technol.等。

研究方向：
金属环境健康及环境地球化学循环机制

招生方向：
环境化学、环境健康、分析化学，欢迎化学、生物、环境、微生物等专业学生报考
专家类别：
高级
职务：

社会任职：
中国环境科学学会环境化学委员会委员
中国仪器仪表协会分析仪器分会原子光谱专业委员会委员
中国仪器仪表协会分析仪器分会离子色谱专业委员会委员

承担科研项目情况：
1. 国家自然科学基金重大研究计划重点支持项目（**），大气金属细颗粒物动物体内赋存研究方法及分布特征，2018/01-2021/12
2.国家自然科学基金重点项目（**）子课题，等离子体质谱分析纳米金属粒子或大气细粒子暴露生物标志物新方法研究，2016/01-2020/12
3.国家自然科学基金面上项目（**），3D打印技术研制ICP-MS单细胞测定技术接口，2017/01-2020/12

获奖及荣誉：

代表论著：
1.Xueting Yan, Bin He*, Lihong Liu, Guangbo Qu, Jianbo Shi, Ligang Hu*, Guibin Jiang, Antibacterial mechanism of silver nanoparticles in Pseudomonas aeruginosa: proteomics approach, Metallomics, 2018, 10, 557-564.
2.Yiling Li, Bin He, Jiejun Gao, Qian S Liu, Runzeng Liu, Guangbo Qu, Jianbo Shi, Ligang Hu*, Guibin Jiang, Methylmercury exposure alters RNA splicing in human neuroblastoma SK-N-SH cells: Implications from proteomic and post-transcriptional responses, Environmental Pollution, 2018, 238, 213-221.
3.Xueting Yan, Bin He*, Lihong Liu, Guangbo Qu, Jianbo Shi, Chunyang Liao, Ligang Hu*, Guibin Jiang, Organotin exposure stimulates steroidogenesis in H295R Cell via cAMP pathway, Ecotoxicology and Environmental Safety, 2018, 156, 148-153.
4.Dingyi Wang, Xiu Huang, Jie Li, Bin He, Qian Liu*, Ligang Hu*, Guibin Jiang, 3D printing of graphene-doped target for "matrix-free" laser desorption/ionization mass spectrometry, Chemical Communications,2018, 54, 2723-2726.
5.Yiling Li, Bin He*, Ligang Hu*, Xiu Huang, Zhaojun Yun, Runzeng Liu, Qunfang Zhou, Guibin Jiang, Characterization of mercury-binding proteins in human neuroblastoma SK-N-SH cells with immobilized metal affinity chromatography, Tatanta, 2018, 178, 811-817.
6.Qian S. Liu, Yuzhen Sun, Guangbo Qu, Yanmin Long, Xingchen Zhao, Aiqian Zhang, Qunfang Zhou*, Ligang Hu*, Guibin Jiang, Structure-Dependent Hematological Effects of Per- and. Polyfluoroalkyl Substances on Activation of Plasma Kallikrein-Kinin System Cascade, Environmental Science and Technology, 2017, 51, 10173-10183.
7.Jie Gao, Ruibin Li, Fengbang Wang, Xiaolei Liu, Jie Zhang, Ligang Hu, Jianbo Shi, Bin He, Qunfang Zhou, Maoyong Song, Bin Zhang, Guangbo Qu*, Sijin Liu, Guibin Jiang, Determining the Cytotoxicity of Rare Earth Element Nanoparticles in Macrophages and the Involvement of Membrane Damage, Environmental Science and Technology, 2017, 51, 13938-13948.
8.Guangbo Qu, Wei Liu, Yuetao Zhao, Jie Gao, Tian Xia, Jianbo Shi, Ligang Hu, Wenhua Zhou, Jiejun Gao, Huaiyu Wang, Qian Luo, Qunfang Zhou, Sijin Liu, Xue-Feng Yu*, Guibin Jiang*, Improved Biocompatibility of Black Phosphorus Nanosheets by Chemical Modification, Angewandte Chemie-International Edition, 2017, 56, 14488-14493.
9.Ligang Hu, Guibin Jiang*, 3D Printing Techniques in Environmental Science and Engineering Will Bring New Innovation, Environmental Science and Technology, 2017, 51, 3597-3599.
10.Yuchuan Wang#, Ligang Hu#, Feng Xu#, Quan Quan, Yau-Tsz Lai, Wei Xia, Ya Yang, Yuen-Yan Chang, Xinming Yang, Zhifang Chai, Junwen Wang, Ivan K. Chu, Hongyan Li, Hongzhe Sun*, Integrative approach for the analysis of the proteome-wide response to bismuth drugs in Helicobacter pylori, Chemical Science, 2017,8, 4626-4633.
11.Aifeng Liu, Jianbo Shi*, Guangbo Qu*, Ligang Hu, Qianchi Ma, Maoyong Song, Chuanyong Jing, Guibin Jiang, Identification of Emerging Brominated Chemicals as the Transformation Products of Tetrabromobisphenol A (TBBPA) Derivatives in Soil, Environmental Science and Technology, 2017, 51, 5434-5444.
12.Yau-Tsz Lai, Ya Yang, Ligang Hu, Tianfan Cheng, Yuen-Yan Chang, Mohamad Koohi-Moghadam, Yuchuan Wang, Jiang Xia, Junwen Wang, Hongyan Li, Hongzhe Sun*, Integration of fluorescence imaging with proteomics enables visualization and identification of metallo-proteomes in living cells, Metallomics, 2017, 9,38-47.
13.Yongguang Yin, Zhiqiang Tan, Ligang Hu, Sujuan Yu, Jingfu Liu*, Guibin Jiang, Isotope Tracers To Study the Environmental Fate and Bioaccumulation of Metal-Containing Engineered Nanoparticles: Techniques and Applications, Chemical Reviews, 2017, 117, 4462-4487,
14.Fang Ji, Chang Wang, Huimin Wang, Guangliang Liu, Bolei Chen, Ligang Hu, Guibin Jiang, Maoyong Song, Yong Liang*, Tetrabromobisphenol A (TBBPA) exhibits specific antimicrobial activity against Gram-positive bacteria without detectable resistance, Chemical Communications, 2017, 53, 3512-3515.
15.Guangbo Qu, Aifeng Liu, Ligang Hu, Sijin Liu*, Jianbo Shi*, Guibin Jiang, Recent advances in the analysis of TBBPA/TBBPS, TBBPA/TBBPS derivatives and their transformation products, TrAC-Trends in Analytical Chemistry, 2016, 83, 14–24.
16.Ruoxi Wen, Xiaoxi Yang, Ligang Hu, Cheng Sun, Qunfang Zhou*, Guibin Jiang*, Brain-targeted distribution and high retention of silver by chronic intranasal instillation of silver nanoparticles and ions in Sprague–Dawley rats, Journal of Applied Toxicology, 2016, 36, 445–453.
17.Ligang Hu*, Yong Cai*, Guibin Jiang, Occurrence and speciation of polymeric chromium(III), monomeric chromium(III) and chromium(VI) in environmental samples, Chemosphere, 2016, 156, 14–20.
18.Cheng Sun, Nuoya Yin, Ruoxi Wen, Wei Liu, Yanxia Jia, Ligang Hu, Qunfang Zhou*, Guibin Jiang, Silver nanoparticles induced neurotoxicity through oxidative stress in rat cerebral astrocytes is distinct from the effects of silver ions, Neurotoxicology, 2016, 52, 210–221.
19.Yongguang Yin, Xiaoya Yang, Ligang Hu, Zhiqiang Tan, Lixia Zhao, Zhen Zhang, Jingfu Liu*, and Guibin Jiang, Superoxide-Mediated Extracellular Biosynthesis of Silver Nanoparticles by the Fungus Fusarium oxysporum, Environmental Science Technology Letter, 2016, 3, 160–165.
20.Qian Liu, Xiaomin Ren, Yanmin Long, Ligang Hu, Guangbo Qu, Qunfang Zhou*, Guibin Jiang, The potential neurotoxicity of emerging tetrabromobisphenol A derivatives based on rat pheochromocytoma cells, Chemosphere, 2016, 154, 194-203.
21.YuchuYau-Tsz, Lai, Yuen-Yan Chang, Ligang Hu, Ya Yang, Ailun Chao, Zhi-Yan Du, Julian A. Tannner, Mee-Len, Chye, Chengmin Qian, Kwan-Ming Ng, Hongyan Li, Hongzhe Sun, Rapid labeling of intracellular His-tagged proteins in living cells, Proceedings of the National Academy of Sciences of the United States of America, 2015, 112, 2948. (Co-first author)
23.Yuchuan, Wang, Ligang Hu, Xinming Yang, Yuen-Yan Chang, Xuqiao Hu, Hongyan Li, Hongzhe Sun, On-line coupling of continuous-flow gel electrophoresis with inductively coupled plasma-mass spectrometry to quantitatively evaluate intracellular metal binding properties of metallochaperones HpHypA and HpHspA in E. coli cells, Metallomics, 2015, DOI:10.1039/C5MT00054H.
24.Hei-Man Vicent Tang, Kewu Pan, Ka-Yiu Edwin Kong, Ligang Hu, Ling-Chim Chan, Kam-Leung Siu, Hongzhe Sun, Chi-Ming Wong, Dong-Yan Jing, Loss of APD1 In yeast confers hydroxyurea sensitivity suppressed by Yap1p transcription factor, Scientific Reports, 2015, 5, 7897.
25.Lingxiangyu Li, Ligang Hu, Qunfang Zhou, Chunhua Huang, Yawei Wang, Cheng Sun, Guibin Jiang, Sulfidation as a natural antidote to metallic nanoparticles is overestimated: CuO sulfidation yields CuS nanoparticles with increased toxicity in Medaka (Oryzias latipes) embryos, Environmental Science & Technology, 2015, 49, 2486.
26.Ligang Hu, Tianfan Cheng, Bin He, Lu Li, Yuchuan Wang, Yau-Tsz Lai, Guibin Jiang Hongzhe Sun, Identification of Metal-Associated Proteins in Cells by Using Continuous-Flow Gel Electrophoresis and Inductively Coupled Plasma Mass Spectrometry, Angewandte Chemie International Edition, 2013, 52, 4916.
27.Ligang Hu, Justin B. Greer, Helena Solo-Gabriele, Lynn Fieber, Yong Cai, Arsenic toxicity in the human nerve cell line SK-N-SH in the presence of chromium and copper, Chemosphere, 2013, 91, 1082.
28.Ligang Hu, Bin He, Yuchuan Wang, Guibin Jiang, Hongzhe Sun, Metallomics in environmental and health related research: Current status and perspectives, Chinese Science Bulletin, 2013, 58, 169.
29.Ligang Hu, Cristina Diez-Rivas, Helena Solo-Gabriele, Lynn Fieber, Abdd Fattah R. Hasan, Yong Cai, Transport and interaction of arsenic, chromium, and copper associated with CCA-treated wood in columns of sand and sand amended with peat, Chemosphere, 2010, 78, 989.
30.Rasem A. Hasan, Ligang Hu, Helena M. Solo-Gabriele, Lynne Fieber, Yong Cai, Timothy G. Townsend, Field-scale leaching of arsenic, chromium and copper from weathered treated wood, Environmental Pollution, 2010, 158, 1479.
31.Ligang Hu, Yong Cai, Biogeochemistry of Arsenic, Progress in Chemistry, 2009, 21, 458.
32.Ligang Hu, Songyun Xu, Chensong Pan,Hanfa Zou, Guibin Jiang, Preparation of biochip on porous silicon and application for label-free detection of small molecule-protein interaction, Rapid Communication in Mass Spectrometry, 2007, 21, 1277.
33.Ligang Hu, Songyun Xu, Chensong Pan, et al. Monitoring Enzyme Reaction and Screening Enzyme Inhibitor Based on MALDI-TOF-MS Platform with a Matrix of Oxidized Carbon Nanotubes. Journal of the American Society for Mass Spectrometry, 2006, 17, 1616.
34.Junjie Ou, Lianghai Hu, Ligang Hu, Xin Li, Hanfa Zou, Determination of phenolic compounds in river water with on-line coupling bisphenol A imprinted monolithic precolumn with high performance liquid chromatography, Talanta, 2006, 69, 1001.
35.Ligang Hu, Songyun Xu, Chensong Pan, Chungang Yuan, Hanfa Zou, Guibin Jiang, Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry with a matrix of carbon nanotubes for the analysis of low-mass compounds in environmental samples. Environmental Science & Technology 2005，39，8442.
36.Chensong Pan, Songyun Xu, Ligang Hu, Xingye Su, Junjie Ou, Hanfa Zou, Zhong Guo, Yu Zhang, Baochuan Guo, Using oxidized carbon nanotubes as matrix for analysis of small molecules by MALDI-TOF MS. Journal of the American Society for Mass Spectrometry 2005, 16, 883.
37.Songyun Xu, Chensong Pan, Ligang Hu, Yu Zhang, Zhong Guo, Xin Li, Hanfa Zou, Enzymatic reaction of the immobilized enzyme on porous silicon studied by matrix-assisted laser desorption/ionization-time of flight-mass spectrometry. Electrophoresis 2004, 25, 3669.
38.Bin He, Guibin Jiang, Ligang Hu, Determination of organomercuries in skin and fur of mink by capillary gas chromatography-atomic absorption spectrometry, Chinese Journal of Analytical Chemistry, 1998, 26, 850.