梁璟

健康与遗传心理学研究室副研究员

电 话:86-

传 真:86-

通讯地址:北京市朝阳区林萃路16号院中科院心理所

邮政编码:100101

电子邮件:liangj@psych.ac.cn

课题组网站:

---

简历：
博士研究生导师
2011 至今　　　　　中国科学院心理研究所　　　　副研究员
2011 - 2013　　　　美国斯坦福大学　　　　　　　访问副教授
2007 - 2011　　　　中国科学院心理研究所　　　　助理研究员
2002 - 2007　　　　北京大学　　　　　　　　　　博士研究生


研究领域：
致力于探索调控情绪及认知过程的神经环路基础，特别关注情绪与认知功能障碍相关精神疾患（药物成瘾、自闭症及老年痴呆）的病理机制的揭示。

社会任职：
中国心理学会生理心理学分会专家委员会委员
北京市神经科学学会青年委员会委员
中国药物滥用与防治协会青年委员会委员


获奖及荣誉：

代表论著：
1)Wang XY#, Qiao YH#, Dai ZH, Sui N, Shen F, Zhang JJ, Liang J*. Medium spiny neurons of the anterior dorsomedial striatum mediate reversal learning in a cell-type-dependent manner. Brain Structure and Function 2019; 224(1):419-434.
2)Piao CJ#, Liu TE#, Ma L, Ding XK, Wang XY, Chen X, Duan Y, Sui N*, Liang J*. Alterations in brain activation in response to prolonged morphine withdrawal-induced behavioral inflexibility in rats. Psychopharmacology 2017; 234(19):2941-2953.
3)Tian TL, Yang CJ, Shang SJ, Cai YJ, Deng XF, Zhang J, Shao F, Zhu DS, Liu YB, Chen GQ, Liang J*, Sun Q*, Qiu ZL*, Zhang C*. Loss of FMRP Impaired hippocampal long-term plasticity and spatial learning in rats. Frontiers in Molecular Neuroscience 2017; Aug 28;10:269. doi: 10.3389/fnmol.2017.00269.
4) Piao CJ, Deng XF, Wang XY, Yuan YR, Liu ZK, Liang J*. Altered function in medial prefrontal cortex and nucleus accumbens links to stress-induced behavioral inflexibility. Behavioural Brain Research 2017;317:16-26.
5)Qiao YH, Wang XY, Ma L, Li SG, Sui N, Liang J*. Functional inactivation of dorsal medial striatum alters recognition process and behavioral flexibility in mice. Physiology & Behavior 2017;179:467-477.
6)Liang J#, Xu W#,*, Hsu YT, Yee A, Chen L, Südhof T*. Conditional neuroligin-2 knockout in adult medial prefrontal cortex links chronic changes in synaptic inhibition to cognitive impairments. Molecular Psychiatry 2015
7)Ding XK, Qiao YH, Piao CJ, Zheng XG, Liu ZK, Liang J*. N-methyl-D-aspartate receptor-mediated glutamate transmission in nucleus accumbens plays a more important role than that in dorsal striatum in cognitive flexibility. Frontiers Behavioral Neuroscience 2014 Sep 5;8:304. doi: 10.3389/fnbeh.2014.00304.
8)Ding XK,Liang J*, Zheng XG, Bai YJ, Liu ZK, Li YY, Xing XL. Altered phosphorylation of GluA1 in the striatum is associated with locomotor sensitization induced by exposure to increasing doses of morphine. European Journal of Pharmacology 2013; 702(1-3):294-301.
9)Liang J#, Ma SS#, Li YJ, Ping XJ, Hu L, Cui CL*. Dynamic changes of tyrosine hydroxylase and dopamine concentration in the VTA-NAc projection during the morphine-CPP expression in rats. Neurochemical Research 2012;37(7):1482-9.
10)Liang J, Zheng XG*, Chen JH, Li YY, Xing XL, Bai YJ, Li YC. Roles of BDNF, dopamine D3 receptors, and their interactions in the expression of morphine-induced context-specific locomotor sensitization. European Neuropsychopharmacology 2011; 21(11):825-34.
11)Liang J, Chen JH, Chen XH, Peng YH, Zheng XG*. Gene expression of conditioned locomotion and context-specific locomotor sensitization controlled by morphine-associated environment. Behavioural Brain Research 2011;216(1):321-31.
12)Liang J, Ping XJ, Li YJ, Ma YY, Wu LZ, Han JS, Cui CL*. Morphine-induced conditioned place preference in rats is inhibited by electroacupuncture at 2 Hz: role of enkephalin in the nucleus accumbens. Neuropharmacology 2010;58(1):233-40.
13)Liang J, Peng YH, Ge XX, Zheng XG*. The expression of morphine-induced behavioral sensitization depends more on treatment regimen and environmental novelty than on conditioned drug effects. Chinese Science Bulletin 2010;55(19):2016-20.
14)Liang J, Li YJ, Ping XJ, Yu P, Zuo YF, Wu LZ, Han JS, Cui CL*. The possible involvement of endogenous ligands for mu-, delta- and kappa-opioid receptors in modulating morphine-induced CPP expression in rats. Peptides 2006;27(12):3307-14.
15)Chen JH, Liang J, Wang GB, Han JS, Cui CL*. Repeated 2 Hz peripheral electrical stimulations suppress morphine-induced CPP and improve spatial memory ability in rats. Experimental Neurology 2005;194(2):550-6.
更多成果信息请见：http://ir.psych.ac.cn/liangj@psych.ac.cn


承担科研项目情况：
1) 国家自然科学基金面上项目，**、自闭症症状相关的“皮层-基底神经节-丘脑-皮层”环路功能失常、2016/01–2019/12、主持；
2) 北京市自然科学基金面上项目，**、内侧前额叶皮层-伏隔核神经环路对于认知灵活性的调控作用、2016/01–2018/12、主持；
3) 国防科技创新特区项目，应激对刺激-反应/习惯记忆的影响与干预措施研究、2017/07-2019/01、主持；
4) 科技部国家重点基础研究发展计划（973）：“精神活性物质成瘾记忆的形成和消除”项目中的“成瘾记忆相关神经元的识别和功能”课题、2015/01–2019/08、技术骨干；
5) 国家自然科学基金面上项目，**、纹状体神经元树突嵴结构及功能重塑在成瘾性用药导致的认知弹性损伤中的作用、2013/01–2016/12、主持；
6) 国家自然科学基金青年科学基金项目，**、伏隔核AMPA受体的突触可塑性在成瘾大鼠戒断后觅药动机行为中的作用、2010/01–2012/12、主持；
7) 中国科学院心理研究所青年基金，08CX053005、药物依赖中觅药动机相关的中脑边缘叶基因表达改变及BDNF调控的D3受体在其中的作用、2008/04–2009/12、主持。

附件：